تاثیر چهار هفته تمرین هوازی با شدت متوسط و مکمل نیگلاپسین (ترکیب روغن سیاه‌دانه و عسل) بر سطح سرمی IgG و IgM در موش صحرایی درمان شده با لیپوپلی ساکارید

نوع مقاله : مقاله پژوهشی

نویسندگان

گروه فیزیولوژی ورزشی، واحد تهران مرکزی، دانشگاه آزاد اسلامی، تهران، ایران

10.22070/daneshmed.2024.18736.1449

چکیده

مقدمه و هدف: با توجه به شیوع بیماری­های ویروسی و التهابات سیستم ایمنی در سراسر دنیا، در جهت بهبود و تقویت عملکرد سیستم ایمنی باید سبک زندگی اصلاح گردد. یکی از بهترین روش­ها استفاده از مکمل­های گیاهی به همراه فعالیت ورزشی می­باشد، که در این مطالعه بررسی شده است.
مواد و روش ها: برای انجام تحقیق آزمایشی حاضر 25 سر موش صحرایی نژاد ویستار از از مرکز سرم­سازی رازی خریداری شده و بطور تصادفی به 5 گروه 5 تایی کنترل- مدل  LPS (lipopolysaccharide)،  تمرین- مدل LPS، مکمل- مدل LPS،  تمرین، مکمل، مدل LPS تقسیم شدند. ایجاد مدل بر روی موش­ها به روش تزریق با ماده LPS با دوز 100 میکروگرم بر کیلوگرم به صورت درون صفاقی به گروه­های مدل بصورت 2 بار در طی 2 هفته انجام شد همچنین گروه­های دیگر به همان میزان دارونما دریافت کردند. سپس گروه­های آزمایشی، به مدت 4 هفته و 3 روز در هفته تمرینات (Moderate Intensity Interval Training) MIT را انجام دادند. همچنین 5 روز در هفته مکمل به صورت گاواژ دریافت کردند. نهایتا داده­ها با استفاده از آزمون تحلیل واریانس یک طرفه و آزمون تعقیبی توکی تجزیه و تحلیل شدند.
نتایج: داده­ها نشان داد تمرین MIT به تنهایی و در تعامل با مکمل موجب کاهش سطح سرمی آنتی­بادی­های IgG و IgM گردیده وتاثیر معنادار دارند (p<0.05).
نتیجه‌گیری: با توجه به نتایج توصیه می شود از تمرینات MIT و مکمل نیگلاپسین (ترکیب سیاهدانه و عسل) جهت تاثیر بر فاکتورهای مهم در سیستم ایمنی استفاده شود.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The effect of 4-week aerobic training with moderate intensity and niglapsin supplement (combination of black seed oil and honey) on the serum level of IgG and IgM in rats treated with lipopolysaccharide

نویسندگان [English]

  • AmirAbbas BaradaranEsfahani
  • Amir HajiGhasem
  • Forouzan Fattahi Masrour
Department of Sports Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
چکیده [English]

Background and Objective: Due to the prevalence of viral diseases and inflammations of the immune system all over the world and in order to improve and strengthen the function of the immune system, lifestyle should be modified. One of the best methods is the use of herbal supplements along with sports activities which is investigated in this study.
Materials and Methods: To conduct the present experimental research, 25 Wistar male rats were purchased from Razi Serum Center and randomly divided into 5 groups : control- LPS model- exercise, LPS model- supplement, LPS model- exercise, supplement and LPS model. Creating a model on rats was done by injecting LPS at a dose of 100 micrograms/kg intraperitoneally to the model groups received the same amount of placebo. Then the experimental groups performed MIT exercises for 4 weeks and 3 days a week and also received supplements by gavage 5 days a week. Finally, the data were analyzed using one-way analysis of variance and Tukey's post hoc test.
Results: The data showed that MIT training alone and in combination with supplements have a significant effect on IgG and IgM antibodies (p<0.05).
Conclusion: According to the results, it is recommended to use MIT exercises and niglapsin supplement (combination of black seed and honey) to affect important factors in the immune system.

کلیدواژه‌ها [English]

  • Aerobic Exercise
  • Black seed
  • Honey
  • IgG
  • IgM

مراجع

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دانشور پزشکی
دوره 32، شماره 2 - شماره پیاپی 171
خرداد و تیر 1403
صفحه 1-9

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