تاثیر تمرین هوازی بر سطوح سرمی فاکتور تمایز رشدی 15 و مقاومت به انسولین در زنان سالمند مبتلا به سندروم متابولیک

نویسندگان

1 گروه فیزیولوژی ورزشی، دانشگاه آزاد اسلامی واحد هشتگرد، البرز، ایران

2 گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه گیلان، رشت، ایران

چکیده

مقدمه و هدف: تمرین هوازی نقش موثری در بهبود اختلالات قلبی-متابولیکی مرتبط با سالمندی و سندروم متابولیک دارد؛ با وجود این نقش این نوع تمرینات بر فاکتور تمایز رشدی 15 (GDF-15) به عنوان بیومارکر جدید پیش گویی کننده اختلالات قلبی درک نشده است. از این­رو، هدف پژوهش حاضر بررسی تاثیر تمرین هوازی بر سطوح سرمی GDF-15 و شاخص مقاومت به انسولین در زنان سالمند مبتلا به سندروم متابولیک بود.
موارد و روش­ها. 24 زن سالمند مبتلا به سندروم متابولیک (سن: 08/4±37/65، وزن: 56/6±98/88، BMI: 47/14±1/34) به طور تصادفی به دو گروه تمرین هوازی (12 نفر) و کنترل (12 نفر) تقسیم شدند. پروتکل تمرین هوازی به مدت 12 هفته، سه جلسه در هر هفته با شدت 50-65 درصد ضربان قلب ماکزیمم اجرا شد. نمونه­های سرمی برای اندازه گیری انسولین، گلوکز و GDF-15 به روش الایزا در دو مرحله پیش آزمون و پس آزمون صورت گرفت.
نتایج. نتایج تحلیل داده­ها نشان داد که تمرین هوازی منجر به کاهش معنی دار GDF-15 نسبت به گروه کنترل شد (05/0˂P < /span>). همچنین، تمرین هوازی با کاهش معنی داری گلوکز سرمی و مقاومت به انسولین همراه بود (05/0˂P < /span>)، در حالی که تاثیر بر انسولین سرمی نداشت (05/0˃P < /span>).
نتیجه گیری. به نظر می رسد که تمرین هوازی نقش موثری در کاهش GDF-15 سرمی داشته باشد که ممکن است به واسطه بهبود شاخص­های متابولیکی و به دنبال آن، کاهش نیاز جبرانی به GDF-15 باشد.

کلیدواژه‌ها


عنوان مقاله [English]

The effect of aerobic training on serum levels of Growth differentiation factor-15 and insulin resistance in elderly women with metabolic syndrome

نویسندگان [English]

  • Kamilia Moghadami 1
  • Maryam Shabani 1
  • Mousa Khalafi 2
چکیده [English]

Background and Objective: Aerobic training plays an important role in the improvement of cardiovascular-metabolic disorders associated with aging and metabolic syndrome; however, the role of this type of training on growth differentiation factor-15 (GDF-15) as a new biomarker for predicting cardiac disorders is not understood. Therefore, the purpose of the present study was to investigate the effect of aerobic training on serum levels of GDF-15 and insulin resistance index in elderly women with metabolic syndrome.
Materials and Method: 24 elderly women with metabolic syndrome (age: 65.37±4.08, weight: 88.98±6.56 kg, BMI: 34.14±1.47) were randomly divided into two groups of aerobic training (n=12) and control group (n=12). The aerobic training protocol was administered for 12 weeks, three sessions per week at an intensity of 65-50% of maximum heart rate. Serum samples were collected in pre-test and post-test for ELISA using insulin, glucose and GDF-15.
Results: Results of data analysis showed that aerobic training resulted in a significant decrease in serum GDF-15 compared to control group (P˂0.05). Also, aerobic training was associated with a significant decrease in serum glucose and insulin resistance (P˂0.05), while it had no effect on serum insulin (P˃0.05).
Conclusion: It seems that aerobic training has an effective role in reducing serum GDF-15, which may be due to the improvement of metabolic parameters and consequently a reduction in the need for GDF-15 compensation.

کلیدواژه‌ها [English]

  • Aerobic training
  • GDF-15
  • Insulin resistance
  • Metabolic Syndrome
  • Aging
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