پاسخ سطح آیرزین سرمی به هشت هفته تمرین هوازی با شدت متوسط در موش‌های صحرایی نر چاق

نویسندگان

1 گروه تربیت بدنی، دانشکده علوم ورزشی، دانشگاه فردوسی مشهد، مشهد، ایران

2 گروه علوم درمانگاهی دانشکده دامپزشکی، دانشگاه فردوسی مشهد، مشهد، ایران

چکیده

مقدمه و هدف: آیرزین به عنوان مایوکاینی ترشح‌شده با فعالیت ورزشی شناخته شده است که نقش مهمی در متابولیسم انرژی و تنظیم بیماری‌های متابولیک مانند چاقی ایفا می‌کند. هدف از مطالعه حاضر اثر هشت هفته تمرین هوازی بر سطح آیرزین سرمی موش‌های صحرایی نر چاق بود.
 
مواد و روش‌ها: در این مطالعه­ی تجربی، تعداد 16 سر موش (وزن 250 الی 300 گرم، نمایه توده بالای 30 گرم بر سانتیمتر مربع) به دو گروه تمرین هوازی با شدت 70 الی 75 درصد حداکثر اکسیژن مصرفی (شدت متوسط) و گروه کنترل تقسیم ­شدند. تمرین هوازی شامل: هشت هفته تمرین هوازی روی نوارگردان، تعداد جلسات تمرینی 5 جلسه در هفته به مدت‌زمان 60 دقیقه در روز اجرا شد. پس از دوره تمرین، سطح آیرزین سرمی، اندازه‌گیری شد. از آزمون t همبسته و مستقل جهت بررسی تفاوت میانگین‌های درون و بین گروهی استفاده شد و برای آزمون فرضیه­ها سطح معناداری 05/0>p < /span> درنظرگرفته­شد.
 
نتایج: سطح آیرزین سرمی، در گروه تمرین هوازی با شدت متوسط نسبت به گروه کنترل افزایش معنی‌دار یافت (18/4=t و 001/0=p < /span>). مقادیر وزن در گروه تمرین هوازی کاهش معنی‌دار یافت.
 
نتیجه‌گیری: بر اساس نتایج به‌دست‌آمده، هشت هفته تمرین هوازی منجر به افزایش معنی‌دار آیرزین سرمی شد. همچنین، به نظر می‌رسد تمرین هوازی با شدت متوسط منجر به افزایش در فرایند گرمازایی، کاهش وزن بدن و افزایش انرژی مصرفی شود.
 

کلیدواژه‌ها


عنوان مقاله [English]

The response of irisin serum levels to eight weeks aerobic training with moderate intensity in obese male Wistar rats

نویسندگان [English]

  • Keyvan Hejazi 1
  • Seyyed Reza Attarzadeh Hosseini 1
  • Mehrdad Fathie 1
  • Mohammad Mosaferi Ziaaldini 1
  • Mahdieh Zaeemi 2
چکیده [English]

Background and Objective: Irisin was identified as a myokine secreted by exercise which plays an important role in energy metabolism and regulation of metabolic diseases such as obesity. The aim of this study was to investigate the effects of eight weeks aerobic training on serum levels of irisin in male obese Wistar rats.
 
Materials and Methods: In this experimental study, 16 adult rats (weight: 250 to 300 g, BMI >30 g/cm2) were divided into two groups: aerobic training with 70 to 75% Vo2max (moderate intensity) and control group. Aerobic training included: eight weeks walking on treadmill (5 sessions/per week for 60 min per session). After the training period, the level of irisin was measured. Statistical techniques for data analysis were paired and independent sample t-test to determine the intra- and inter-group comparisons between groups and the level of significance was considered at p<0.05.
 
Results: The serum levels of irisin in the aerobic training group with moderate intensity significantly increased as compared to the control group (t=4.18, p=0.001). In addition, weight in aerobic training significantly reduced.
 
Conclusion: According to the results, eight weeks of aerobic training lead to a significant increase in serum levels of irisin. Moreover, it seems that aerobic training with moderate intensity has led to an increase in theremogenesis, weight loss, and energy expenditure.
 

کلیدواژه‌ها [English]

  • Irisin
  • Aerobic training
  • Obese rats
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