نویسندگان
مرکز تحقیقات سلولی و ملکولی، دانشگاه علوم پزشکی قزوین
چکیده
کلیدواژهها
عنوان مقاله [English]
نویسندگان [English]
Background and Objective: Several lines of evidence show that high plasma level
of homocysteine (Hcy) induces development or exacerbates Parkinson’s disease.
B vitamins are necessary for Hcy metabolism and control plasma level of Hcy. In
the present study, we studied the effect of B vitamin supplementation on the
6-hydroxydopamine (6-OHDA)-induced Parkinsonism in rat. Materials and Methods: Rats were nourished with B vitamin supplements from 1 month
before the surgery till the end of experiment. 6-OHDA was injected into the
striatum of rat brains by stereotaxic surgery. Development and severity of the
Parkinsonism were assessed by three conventional behavioral tests. Serum level
of Hcy was measured before the surgery and at the end of experiment. Results:
Supplement of B complex significantly attenuated behavioral symptoms of the
Parkinsonism. Supplement of B6 improved
rotational behavior of the rats but had no effect on the swing and rotarod
tests. Supplements of B12 and combination of B6, B12
and folate had no remarkable effect. Supplements of B6, B12
and B complex decreased serum level of Hcy before the surgery. In the end of
the experiment, however, there was no significant difference for serum level of
Hcy between experimental groups. Conclusion:
Our results indicate that high intake of B complex can provide
anti-Parkinsonism effect which is not mediated by lowering plasma Hcy.
کلیدواژهها [English]
)