نویسندگان
1 گروه فیزیولوژی ورزش،دانشکده علوم انسانی، دانشگاه آزاد ساری
2 دانشگاه آزاد واحد قائم شهر، قائم شهر
3 گروه فیزیولوژی ورزش، دانشکده علوم انسانی، دانشگاه azad university of sari
چکیده
کلیدواژهها
عنوان مقاله [English]
نویسندگان [English]
Background and Objective: Lead can cause liver damage in which
oxidative stress is involved. Exercise and use of anti-oxidative substances such as anti-oxidative curcumin may stop < /span>
the production of free radicals. The purpose of the present study was
to investigate the protective effect of endurance
training and curcumin against lead toxic effect on hepatic tissue in male rats. Materials and
Methods: In this experimental study, 60
male Wistar rats were randomly
divided into 6 groups, control , sham, lead, exercise + lead, curcumin+lead and exercise+lead+curcumin (n=10 in each group). The exercise training
consisted of 25-64 min of running on an ungraded
treadmill at a speed of
15-22 m/min for 8 weeks. Curcumin (30 mg/kg) and lead (20 mg/kg of lead acetate) were administered for 8 weeks, 3 days/week, intraperitoneally. Serum ALT, AST and ALP were measured by colorimetric method. Results: The results showed that 8 weeks of lead
exposure causes a significant increase of AST and ALT
in the lead group < /font>
as compared to control group < /font> (p =0.002,
p = 0.007, respectively). Endurance training and curcumin consumption significantly decreased AST and
ALT(p =0.041 and p =0.009, respectively). After endurance training and curcumin consumption, ALP non-significantly decreased
(p =0.692). Conclusion: Regular exercise and curcumin supplement may
inhibit liver damage induced
by lead.
کلیدواژهها [English]
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