نویسندگان
1 گروه داخلی و نفرولوژی، دانشکده پزشکی، دانشگاه شاهد
2 گروه فیزیولوژی، مرکز تحقیقات نوروفیزیولوژی، دانشکده پزشکی، دانشگاه شاهد
3 دانشگاه شاهد
چکیده
کلیدواژهها
عنوان مقاله [English]
نویسندگان [English]
Background and Objective: Diabetes mellitus accompanies enhanced
oxidative stress and decreased activity of antioxidant defense system. Due to
the significant role of enhanced oxidative stress in development of renal
damage and nephropathy in diabetes and with regard to antidiabetic and antioxidant
effect of apigenin, this study was conducted to evaluate the effect of this
flavonoid on the level of some oxidative stress-associated factors in kidney
tissue of diabetic rats. Materials and Methods: Male rats were divided into 4 groups,
i.e. control, apigenin-treated control, diabetic, and apigenin-treated diabetic
groups. Apigenin was administered at a dose of 10 mg/kg for three weeks
starting seven days after diabetes induction using streptozotocin. Tissue level
of malondialdehyde (MDA) and nitrite and nitrate and activity of superoxide
dismutase (SOD) in kidney tissue were measured at the end of the study. Results: Diabetic rats had a significant increase in tissue level
of malondialdehyde (p < 0.01) and nitrite (p < 0.05) and a lower level of SOD
activity (p < 0.01) as compared to control group and treatment of diabetic
rats with apigenin did not significantly reduce MDA and nitrite level and also
did not significantly enhance SOD activity in diabetic group. Conclusion: Chronic apigenin treatment could not
significantly change some measured markers of oxidative stress in renal tissue
in this study from diabetic rats and its antioxidant effect is not potent
enough to prevent renal damage in streptozotocin-induced model of diabetes.
کلیدواژهها [English]
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