نویسندگان
1 گروه فیزیولوژی، دانشکده پزشکی، مرکز تحقیقات فیزیولوژی و مرکز تحقیقات دیابت، دانشگاه علوم پزشکی جندی‌شاپور
2 گروه فیزیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی جندی‌شاپور
3 گروه فیزیولوژی، دانشکده پزشکی، مرکز تحقیقات دانشجویی، دانشگاه علوم پزشکی جندی‌شاپور
4 دانشکده پیراپزشکی، مرکز تحقیقات دانشجویی، دانشگاه علوم پزشکی جندی‌شاپور
چکیده
کلیدواژه‌ها
عنوان مقاله [English]
نویسندگان [English]
Background and Objective: Daucus carota has
antioxidant effect and a high content of beta carotene. It has been reported
that Daucus carota has estrogenic and hormonal effects on female
reproductive system. Since there was no experimental research about the effect
of this plant on uterus contraction, we therefore decided to study the effect
of aqueous extract of Daucus carota on uterus contractions. Materials and Methods: In this experimental study, 32 virgin
Wistar rats (200-300 g) were divided into 4 groups. After inducing contraction
with KCL, oxytocin and incubation with propranolol and naloxane, the effect of
various doses of the extract was assessed. After laparatomy, a piece of uterus
(1.5 cm) was excised and mounted in an organ bath (10 ml) containing De Jalon
(29 °C). Then, pieces of uterus were contracted with KCL and oxytocin and aqueous
extract of Daucus carota at doses of 0.1-0.8 mg/ml was added to organ
bath in the presence of KCL and oxytocin. In this study, the uterus was
separately incubated with propranolol (1 µM),
naloxone (1 µM) and the role of β-adrenoceptors
and opioid receptors were also evaluated. Results: Cumulative concentrations of the extract
dose-dependently decreased uterine contractions induced by KCl (p < 0.05) and
oxytocin (p < 0.001). Also, incubation of tissues with propranolol and
naloxone did not have any role in the effect of this extract. Conclusion: The results of this study suggest that
antispasmodic effect of aqueous extract of Daucus carota probably accomplished via voltage dependent
calcium channels blockade and β-adrenoceptors and opioid receptors did not have
any role in this effect.
کلیدواژه‌ها [English]
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