نویسندگان
1 مرکز تحقیقات نوروفیزیولوژی، دانشگاه شاهد
2 دانشگاه علوم پزشکی تهران، دانشکده پزشکی، گروه فیزیولوژی تهران
چکیده
کلیدواژهها
عنوان مقاله [English]
نویسندگان [English]
Background and Objective: Curcumin exhibits
antidiabetic and antioxidant effect and memory augmenting property. This study
was done to evaluate the effect of its chronic administration on the learning
and memory of diabetic rats. Materials and Methods: In this experimental study, Wistar
rats were divided into 5 groups, i.e. control, curcumin-treated control (50
mg/kg), diabetic, and curcumin-treated diabetic groups (10 and 50 mg/kg).
Curcumin was administered 7 days after streptozotocin injection for 5 weeks.
For evaluation of learning and memory, passive avoidance and Y-maze tests were
used. Level of malondialdehyde in hippocampus was also measured. Results: STL significantly decreased in diabetic
(p < 0.01) and low-dose curcumin-treated diabetic (p < 0.05) groups and this
parameter was significantly higher in diabetic group receiving high-dose
curcumin as compared to diabetics (p < 0.05). Meanwhile, alternation
percentage was significantly lower in diabetic group relative to control
(p < 0.05) and high-dose-treated diabetic group showed a significant increase
in comparison with diabetic group (p < 0.05). Meanwhile, high-dose curcumin
significantly reduced level of MDA in diabetic group (p < 0.05). Conclusion: Chronic treatment with curcumin at a
dose of 50 mg/kg could enhance the capability of consolidation and recall in
diabetic animals and could improve short-term spatial memory in diabetic
animals.
کلیدواژهها [English]
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