دانشور پزشکی

دانشور پزشکی

ارتباط سابقه کولیک شیرخواری با میگرن در کودکان مراجعه‌کننده به درمانگاه‌های اعصاب کودکان ارومیه در سال 1402 Correlation Between History of Infant Colic and Migraine in Children Referred to Children's Neurology Clinics in Urmia in 1402

نوع مقاله : مقاله پژوهشی

نویسندگان
عزت الله عباسی 1
علیرضا عبدی 2
شیما عباسی 3
1 1دانشیار گروه بیماری‌های کودکان، دانشکده پزشکی، دانشگاه علوم پزشکی ارومیه، ارومیه، ایران
2 استادیار گروه بیماری‌های کودکان، دانشکده پزشکی، دانشگاه علوم پزشکی ارومیه، ارومیه، ایران
3 دانشجوی پزشکی عمومی، دانشکده پزشکی، دانشگاه علوم پزشکی ارومیه، ارومیه، ایران
10.22070/daneshmed.2025.20292.1599
چکیده
زمینه ‌و هدف: کولیک شیرخوارگی یک مشکل شایع در سه‌ ماهه ابتدایی زندگی نوزادان می‌باشد. میگرن از علل شایع سردردهای اولیه در دوران کودکی است. پاتوژنز کولیک شیرخوارگی و میگرن ناشناخته است. با این‌حال، شواهدی مبنی‌بر ارتباط سردردهای میگرنی در کودکی و نوجوانی با کولیک شیرخوارگی وجود دارد. مطالعه حاضر با هدف تعیین ارتباط سابقه کولیک شیرخوارگی با میگرن در کودکان مراجعه‌کننده به درمانگاه‌های اعصاب کودکان ارومیه انجام شد.
مواد و روش‌ها: این مطالعه به‌روش مورد-شاهدی روی 200 کودک 6-18 ساله مراجعه‌کننده به درمانگاه‌های اعصاب کودکان ارومیه (سال 1402) در دو گروه مبتلا به سردردهای میگرنی (100 نفر، گروه مورد) و غیرمبتلا به سردردهای میگرنی (100 نفر، گروه شاهد) انجام شد. اطلاعات لازم با پرسش از والدین و شواهد پزشکی جمع‌آوری و تجزیه‌و‌تحلیل داده‌ها با استفاده از آزمون‌های t مستقل و مجذور کای انجام شد.
نتایج: میانگین سنی کودکان مبتلا به میگرن 2/3±3/11 سال و در گروه شاهد  1/2±6/10 بود، که به ترتیب 52 درصد و 42 درصد از آن‌ها پسر بودند. از نظر سن و جنسیت تفاوت معنی‌داری بین گروه‌های مورد و شاهد مشاهده نشد (به‌ترتیب 277/0P= و 202/0P=). نتایج نشان‌دهنده ارتباط معنی‌دار کولیک شیرخوارگی (001/0P<)، سابقه خانوادگی میگرن (001/0P<) و کولیک شیرخوارگی در فرزند دیگر خانواده (001/0P<) با احتمال بروز سردردهای میگرنی در آینده بود.
نتیجه‌گیری: این مطالعه شواهدی مبنی‌بر وجود ارتباط کولیک نوازادی، سابقه خانوادگی میگرن و کولیک شیرخوارگی در فرزند دیگر خانواده با احتمال بروز سردردهای میگرنی در دوران کودکی و نوجوانی ارائه می‌دهد. با این‌حال، باتوجه‌ به محدودیت‌های مطالعه از جمله گذشته‌نگر بودن و احتمال سوگیری یادآوری، نتایج این مطالعه باید با مطالعات آتی تکمیل شود.
Background and Objective: Infantile colic is a prevalent condition during the first three months of an infant's life. Migraine is a frequent cause of recurrent primary headache in childhood. The pathogenesis of infantile colic and migraine remains unclear. However, evidence suggests an association between childhood and adolescent migraine headaches and infantile colic. This study aimed to investigate the association between a history of infantile colic and migraine in children referred to the Urmia Pediatric Neurology Clinics.
Materials and Methods: This case-control study was conducted on 200 children aged 6–18 years who were referred to Urmia Pediatric Neurology Clinics in 1402. Participants were divided into two groups: those with migraine headaches (n=100) and those without (n=100), serving as the case and control groups, respectively. Data were collected through parental interviews and medical records. Statistical analyses were performed using independent t-tests and Fisher's exact test.
Results: The mean age of the children with migraine was 11.3±3.2 years and in control group was 10.6±2.1, with 52% and 42% being male in case and control group, respectively. No significant differences in age or sex were observed between the case and control groups (P=0.277 and P=0.202, respectively). The results indicated a significant association between infantile colic (P<0.001), family history of migraine (P<0.001), and the presence of infantile colic in another child in the family (P<0.001) with the likelihood of developing migraine headaches in the future.
Conclusion: This study provides evidence that infantile colic, a family history of migraine, and the occurrence of infantile colic in another child in the family are associated with an increased likelihood of developing migraine headaches in childhood and adolescence. However, owing to the study's limitations, including its retrospective nature and potential recall bias, further research is necessary to corroborate these findings.
کلیدواژه‌ها
کولیک شیرخواری
میگرن
کودکان
سردرد Infantile Colic؛ Migraine؛ Children؛ Headache
موضوعات
  1. Amiri Parsa T, Khademosharie M, Hamedinia M, Azarnive M. Evaluation of the Factors Associated with Overweight and Obesity in 30-to 50-year-old Women of Sabzevar. Iranian Journal of Epidemiology 2014;9(4):75-83.
  2. Scotton WJ, Botfield HF, Westgate CS, Mitchell JL, Yiangou A, Uldall MS, et al. Topiramate is more effective than acetazolamide at lowering intracranial pressure. Cephalalgia 2019;39(2):209-18.
  3. Ailani J, Burch RC, Robbins MS, Society BoDotAH. The American Headache Society Consensus Statement: Update on integrating new migraine treatments into clinical practice. Jornal of Head and Face Pain 2021;61(7):1021-39.
  4. Onofri A, Pensato U, Rosignoli C, Wells-Gatnik W, Stanyer E, Ornello R, et al. Primary headache epidemiology in children and adolescents: a systematic review and meta-analysis. Journal of Headache and Pain 2023;24(1):8-12.
  5. Mohammadi P, Khodamorovati M, Vafaee K, Hemmati M, Darvishi N, Ghasemi H. Prevalence of migraine in Iran: a systematic review and meta-analysis. BMC Neurolology 2023;23(1):172-80.
  6. Stovner LJ, Nichols E, Steiner TJ, Abd-Allah F, Abdelalim A, Al-Raddadi RM, et al. Global, regional, and national burden of migraine and tension-type headache, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurolology 2018;17(11):954-76.
  7. Nieswand V, Richter M, Gossrau G. Epidemiology of headache in children and adolescents—another type of pandemia. Current Pain Headache Reports 2020;24:1-10.
  8. Zhang D, Zhang Y, Sang Y, Zheng N, Liu X. The relationship between infant colic and migraine as well as tension‐type headache: a meta‐analysis. Pain Research and Management 2019;2019(1):12-20.
  9. Karceski S, Parikh NS. Infant colic and migraine: Is there a connection? Neurology 2012;79(13):112-5.
  10. Jalali F, Nahvi S, Jalali N, Kamiab Z. The Relationship Between Maternal Migraine and Infantile Colic: A Case-Control Study. Iranian Journal of Pediatrics 2024;34(2):12-20.
  11. Gelfand AA, Goadsby PJ, Allen IE. The relationship between migraine and infant colic: a systematic review and meta-analysis. Cephalalgia 2015;35(1):63-72.
  12. Lucassen P, Assendelft W, Van Eijk JTM, Gubbels J, Douwes A, Van Geldrop W. Systematic review of the occurrence of infantile colic in the community. Archives of Disease in Childhood 2001;84(5):398-403.
  13. van den Berg MP, van der Ende J, Crijnen AA, Jaddoe VW, Moll HA, Mackenbach JP, et al. Paternal depressive symptoms during pregnancy are related to excessive infant crying. Pediatrics 2009;124(1):96-103.
  14. Castro-Rodrıguez JA, Stern DA, Halonen M, Wright AL, Holberg CJ, Taussig LM, et al. Relation between infantile colic and asthma/atopy: a prospective study in an unselected population. Pediatrics 2001;108(4):878-82.
  15. Barr RG, Trent RB, Cross J. Age-related incidence curve of hospitalized Shaken Baby Syndrome cases: convergent evidence for crying as a trigger to shaking. Child Abuse and Neglect 2006;30(1):7-16.
  16. Metcalf TJ, Irons TG, Sher LD, Young PC. Simethicone in the treatment of infant colic: a randomized, placebo-controlled, multicenter trial. Pediatrics 1994;94(1):29-34.
  17. Kukkonen K, Savilahti E, Haahtela T, Juntunen-Backman K, Korpela R, Poussa T, et al. Long-term safety and impact on infection rates of postnatal probiotic and prebiotic (synbiotic) treatment: randomized, double-blind, placebo-controlled trial. Pediatrics 2008;122(1):8-12.
  18. Gudmundsson G. Infantile colic: Is a pain syndrome. Medical Hypothesis 2010;75(6):528-9.
  19. Wolke D, Bilgin A, Samara M. Systematic review and meta-analysis: fussing and crying durations and prevalence of colic in infants. Journal of Pediatrics 2017;185:55-61.
  20. Bigal ME, Arruda MA. Migraine in the pediatric population—evolving concepts. Journal of Head and Face Pain 2010;50(7):1130-43.
  21. Toosi MB, Ghodsi A, Sarabi M, Ghahremani S, Fazeli N, Ghahremani S. Investigating the Frequency of Infantile Colic in Children with Migraine. Journal of Child Science 2021;11(01):89-92.
  22. Abu-Arefeh I, Russell G. Prevalence of headache and migraine in schoolchildren. British Medical Journal 1994;309(6957):765-9.
  23. Young JC, Widom CS. Long-term effects of child abuse and neglect on emotion processing in adulthood. Child Abuse and Neglect 2014;38(8):1369-81.
  24. Talachian E, Bidari A, Rezaie MH. Incidence and risk factors for infantile colic in Iranian infants. World Journal of Gastroenterology 2008;14(29):46-62.
  25. Indrio F, Dargenio VN, Francavilla R, Szajewska H, Vandenplas Y. Infantile colic and long-term outcomes in childhood: a narrative synthesis of the evidence. Nutrients 2023;15(3):615-8.
  26. Helseth S, Misvær N, Småstuen M, Andenæs R, Valla L. Infant colic, young children’s temperament and sleep in a population based longitudinal cohort study. BMC Pediatrics 2022;22(1):163-70.
  27. Petzoldt J. Systematic review on maternal depression versus anxiety in relation to excessive infant crying: it is all about the timing. Archives of Women's Mental Health 2018;21(1):15-30.
  28. Martini J, Petzoldt J, Knappe S, Garthus-Niegel S, Asselmann E, Wittchen H-U. Infant, maternal, and familial predictors and correlates of regulatory problems in early infancy: The differential role of infant temperament and maternal anxiety and depression. Early Human Development 2017;115:23-31.
  29. Ruschel MAP, De Jesus O. Migraine headache. StatPearls [Internet]: StatPearls Publishing; 2024.
  30. Pelzer N, Louter MA, van Zwet EW, Nyholt DR, Ferrari MD, van den Maagdenberg AM, et al. Linking migraine frequency with family history of migraine. Cephalalgia 2019;39(2):229-36.
  31. Eidlitz-Markus T, Haimi-Cohen Y, Zeharia A. Association of age at onset of migraine with family history of migraine in children attending a pediatric headache clinic: a retrospective cohort study. Cephalalgia 2015;35(8):722-7.
  32. Mortimer M, Kay J, Jaron A. Epidemiology of headache and childhood migraine in an urban general practice using Ad Hoc, Vahlquist and IHS criteria. Developmental Medicine and Child Neurology 1992;34(12):1095-101.
  33. Dalsgaard-Nielsen T, Engberg-Pedersen H, Holm H. Clinical and statistical investigations of the epidemiology of migraine. Danish Medical Bulletin 1970;17(5):138-48.
  34. Egermark‐Eriksson I. Prevalence of headache in Swedish schoolchildren: a questionnaire survey. Acta Paediatrica 1982;71(1):135-40.
  35. Sillanpää M. Changes in the prevalence of migraine and other headaches during the first seven school years. Headache: The Journal of Head and Face Pain 1983;23(1):15-9.
  36. Levinsky Y, Eidlitz-Markus T. Comparison of the Prevalence of Infantile Colic Between Pediatric Migraine and Other Types of Pediatric Headache. Journal of Child Neurololog 2020;35(9):607-11.
  37. Zhang D, Zhang Y, Sang Y, Zheng N, Liu X. The relationship between infant colic and migraine as well as tension‐type headache: a meta‐analysis. Pain Research and Management 2019;2019(1):8307982.
دانشور پزشکی
دوره 33، شماره 1 - شماره پیاپی 176
فروردین و اردیبهشت 1404
صفحه 47-52