اثر 12 هفته تمرین‌ تناوبی با سه ‌شدت مجزا برسطح مایوستاتین سرمی زنان غیرفعال چاق و دارای‌ اضافه ‌وزن

نوع مقاله : مقاله پژوهشی

نویسندگان

1 اداره آموزش و پرورش بجنورد، بجنورد، ایران

2 گروه تربیت بدنی و علوم ورزشی، دانشگاه حکیم سبزواری، سبزوار، ایران

چکیده

مقدمه و هدف: افزایش هزینه انرژی در درمان چاقی و اختلالات آن ضروری است. مایوستاتین می­تواند این سازوکار ­را تضعیف نماید، درحالیکه تمرین ورزشی مهارکننده­ی مایوستاتین است. پژوهش حاضر به بررسی اثر۱۲ هفته تمرین تناوبی با سه شدت کم، متوسط و زیاد برمایوستاتین سرم زنان غیرفعال­چاق و دارای اضافه­وزن پرداخته است.
 مواد و روش ها: در مطالعه ­حاضر، 47 زن (25/3±2/40سال) غیرفعال چاق و دارای اضافه ­وزن به­­ روش تصادفی­ساده در چهارگروه شدت کم، شدت­ متوسط، شدت ­زیاد وکنترل قرارگرفتند (هرگروه تمرینی12وکنترل11نفر). برنامه­تمرین ­تناوبی12 هفته­ای با سه­جلسه در هفته و شدت­های50 تا 63‌، 64 تا 76 و 77 تا93 درصد حداکثر ­ضربان قلب به ­اجرا درآمد.نمونه­گیری درحالت ناشتا انجام گرفت. آنالیز داده­های آماری با آزمون تحلیل­ واریانس اندازه­های مکرر در سطح معنی­داری (05/0p<) انجام شد.
نتایج: 12هفته تمرین­تناوبی با شدت­های مختلف، تغییر معنی­داری در مایوستاتین سرم زنان غیرفعال­چاق و دارای اضافه­­وزن ایجاد نکرد، همچنین بین ­گروه­های­ تمرینی تفاوت معنی­داری مشاهده نشد(05/0P>).ازطرفی در هر سه شدت تمرینی اختلافات معنی­داری در شاخص­های ترکیب ­بدن و VO2max­(بیشینه ­اکسیژن ­مصرفی برحسب میلی‌لیتر درکیلوگرم وزن بدن دردقیقه) درمقایسه با قبل آن ایجاد شد. اختلافات معنی­داری درشاخص ­نسبت ­دورکمر ­به­ دور لگن و شاخص­ توده­ بدنی بین ­گروه شدت زیاد و گروه کنترل، در شاخص درصد چربی ­بدن بین هر سه شدت ‌تمرینی با گروه کنترل و در شاخص VO2max بین گروه شدت زیاد با سه گروه دیگر و بین گروه شدت متوسط با گروه­ کنترل ملاحظه گردید.
نتیجه‌گیری: با وجود عدم­ تغییر ­مایوستاتین سرم متعاقب12 هفته تمرین ­تناوبی با سه شدت مختلف، تغییرات مطلوبی در شاخص­های ترکیب­بدن و VO2max با برتری گروه شدت زیاد نسبت به سایر گروه­های تمرینی ایجاد شد، بنابراین می­توان ازاین شدت تمرینی برای بهبود مطلوب ترکیب­بدن و افزایش VO2max زنان غیرفعال چاق و دارای اضافه­وزن استفاده نمود.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The effect of 12 weeks of interval training with three different intensities on the serum myostatin level of inactive obese and overweight women

نویسندگان [English]

  • Saeed Ramezani 1
  • Zeynab Firozeh 1
  • Amir Hossein Haghighi 2
  • mohamadreza hamedinia 2
1 Bojnourd Education Department, Bojnourd, Iran
2 Department of Physical Education, University of Hakim Sabzevari, Sabzevar, Iran
چکیده [English]

Background and Objective: Increasing energy expenditure is necessary in the treatment of obesity and its disorders.Myostatin can weaken this mechanism, while exercise is an inhibitor of myostatin.The present study investigated the effect of 12weeks of interval training with three intensities of low, medium and high on serum myostatin of inactive-obese and overweight women.
Materials and Methods: In the present study, 47inactive, obese and overweight women (40.2±3.25 years old) were randomly assigned to four groups: low, moderate, high intensity and control. A 12 week interval training program with three sessions per week and intensities of 50-63, 64-76 and 77-93% of the maximum heart rate was implemented. Sampling was done in the fasting state. Statistical data was analyzed by ANOVA for repeated measures at a significant level of p<0.05.
Results: 12 weeks of interval training in different intensities did not cause a significant change in the serum myostatin in inactive obese and overweight women and between the exercise groups (P>0.05). In three intensities, there were significant differences in the indicators of body composition and VO2max compared to the before training. Significant differences in the waist to hip ratio and bodymass index between the high intensity and control group, in the body fat percentage index between three exercise intensities with control group and inVO2max between high intensity and three other groups and between the moderate intensity and control group was observed.
Conclusion: Despite the lack of change in serum myostatin after12 weeks of interval training with three different intensities, there were favorable changes in the body composition and VO2max indices with the superiority of the high intensity group compared to other training groups. Therefore,this training intensity can be used to improve the body composition and increase theVO2max of obese and overweight inactive women.

کلیدواژه‌ها [English]

  • Myostatin
  • Interval training
  • Obesity
  • Fat browning
  • Inactive women

مراجع

  1. GBD 2015 Obesity Collaborators et al. “Health Effects of Overweight and Obesity in 195 Countries over 25 Years.” The New England journal of medicine 2017;377(1): 13-27. doi:10.1056/NEJMoa1614362.
  2. Pervin, S., Reddy, S. T., & Singh, R. Novel Roles of Follistatin/Myostatin in Transforming Growth Factor-β Signaling and Adipose Browning: Potential for Therapeutic Intervention in Obesity Related Metabolic Disorders. Frontiers in endocrinology2021; 12:653179. https://doi.org/10.3389/fendo.2021.653179.
  3. Bartelt A, Heeren J. Adipose tissue browning and metabolic health. Nature Reviews Endocrinology2014;10(1):24-36. DOI: 10.1038/nrendo.2013.204.
  4. Rolfe, D. F., & Brown, G. C. Cellular energy utilization and molecular origin of standard metabolic rate in mammals. Physiological reviews. (1997);77(3): 731– https://doi.org/10.1152/physrev.1997.77.3.731
  5. Van Marken Lichtenbelt, W. D., & Schrauwen, P. Implications of nonshivering thermogenesis for energy balance regulation in humans. American journal of physiology. Regulatory, integrative and comparative physiology2011;301(2):R285– https://doi.org/10.1152/ajpregu.00652.2010
  6. Singh, R., Braga, M., & Pervin, S. Regulation of brown adipocyte metabolism by myostatin/follistatin signaling. Frontiers in cell and developmental biology2014; 2:60. https://doi.org/10.3389/fcell.2014.00060.
  7. Das, D. K., Graham, Z. A., & Cardozo, C. P. Myokines in skeletal muscle physiology and metabolism: Recent advances and future perspectives. Acta physiologica (Oxford, England) 2020;228(2): e13367. https://doi.org/10.1111/apha.13367.
  8. Ge X, Sathiakumar D, BJG L, Kukreti H, Lee M , McFarlane C. Myostatin signals through miR-34a to regulate Fndc5 expression and browning of white adipocytes. International Journal of Obesity 2016; 145(2): 161-180.
  9. Mendez-Gutierrez, A., Osuna-Prieto, F. J., Aguilera, C. M., Ruiz, J. R., & Sanchez-Delgado, GEndocrine Mechanisms Connecting Exercise to Brown Adipose Tissue Metabolism: a Human Perspective. Current diabetes reports2020; 20(9): 40. https://doi.org/10.1007/s11892-020-01319-7.
  10. Bagheri, R., Moghadam, B. H., Church, D. D., Tinsley, G. M., Eskandari, M., Moghadam, B. H., Motevalli, M. S., Baker, J. S., Robergs, R. A., & Wong, A. The effects of concurrent training order on body composition and serum concentrations of follistatin, myostatin and GDF11 in sarcopenic elderly men. Experimental gerontology 2020;133: 110869. https://doi.org/10.1016/j.exger.2020.110869 2020;133:110869.
  11. Allen, D. L., Hittel, D. S., & McPherron, A. C. Expression and function of myostatin in obesity, diabetes, and exercise adaptation. Medicine and science in sports and exercise 2011;43(10); 1828– https://doi.org/10.1249/MSS.0b013e3182178bb4.
  12. Kabak B, Belviranli M, Okudan N. Irisin and myostatin responses to acute high-intensity interval exercise in humans. Hormone molecular biology and clinical investigation 2018;35(3):20180008.
  13. Paoli A, Pacelli QF, Neri M, Toniolo L, Cancellara P, Canato M, et al. Protein supplementation increases postexercise plasma myostatin concentration after 8 weeks of resistance training in young physically active subjects. Journal of Medicinal Food 2015;18(1):137– 43.
  14. Martinez-Huenchullan SF, Ban LA, Olaya-Agudo LF, Maharjan BR, Williams PF, Tam CS, et al. Constant-Moderate and high-intensity interval training have differential benefits on insulin sensitive tissues in high-fat fed mice. Frontiers in Physiology 2019;10:459. doi: 10.3389/fphys.201 9.00459.
  15. Motiani, Piryanka et al. “Decreased insulin-stimulated brown adipose tissue glucose uptake after short-term exercise training in healthy middle-aged men.” Diabetes, obesity & metabolism 2017;19(10) :1379-88. doi:10.1111/dom.12947.
  16. Viana RB, Naves JPA, Coswig VS, de Lira CAB, Steele J, Fisher JP, et al. Is interval training the magic bullet for fat loss? A systematic review and meta-analysis comparing moderate-intensity continuous training with high-intensity interval training (HIIT). British Journal of Sports Medicine 2019;53:655– doi: 10.1136/bjsports-2018-099928.
  17. Pekkala S, Wiklund PK, Hulmi JJ, Ahtiainen JP, Horttanainen M, Pollanen E, et al. Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health?. The Journal of Physiology 2013; 591(21):5393-400.
  18. Vidal P, Stanford KI. Exercise-Induced Adaptations to Adipose Tissue Thermogenesis.Frontiers in endocrinology(Lausanne) 2020;11:270. DOI: 10.3389/fendo.2020.00270
  19. Shabani R, Izaddoust F. Effects of aerobic training, resistance training, or both on circulating irisin and myostatin in untrained women. Acta Gymnica 2018; 2(48): 47–55.
  20. Lundberg TR, Fernandez-Gonzalo R, Gustafsson T, Tesch PA. Aerobic exercise alters skeletal muscle molecular responses to resistance exercise. Medicine & Science in Sports & Exercise 2012;44(9):1680-8.
  21. Hofmann M, Schober-Halper B, Oesen S, Franzke B, Tschan H, Bachl N. et al. Effects of elastic band resistance training and nutritional supplementation on muscle quality and circulating muscle growth and degradation factors of institutionalized elderly women. European Journal of Applied Physiology 2016; 116: 885–897.
  22. Elliott BT, Herbert  P, Sculthorpe N, Grace FM, Stratton D, Hayes LD. Lifelong exercise, but not short term high intensity interval training, increases GDF11, a marker of successful aging: a preliminary investigation. Physiological Reports 2017; 5(13): 13343.
  23. Schiffer T, Geisler S, Sperlich B, Strüder H. MSTN mRNA after varying exercise modalities in humans. International journal of sports medicine 2011; 32(9): 683-7.
  24. Segsworth D, Blair M. Acute sprint interval exercise induces a greater FGF-21 response in comparison to work-matched continuous exercise. Electronic Thesis and Dissertation Repository 2015; 21: 3254.
  25. Jackson AS, Pollock ML. Generalized equations for predicting body density of men. British Journal of Nutrition. 1978; 40(3): 497-504.
  26. Kline GM, Porcari JP, Hintermeister R, Freedson PS, Ward A, McCarron RF, Ross J, Rippe JM. Estimation of VO2max from a one-mile track walk, gender, age, and body weight. Medicine & Science in Sports & Exercise 1987;19(3):253-9.
  27. Thompson WR, Gordon NF, Pescatello LS. ACSM's guidelines for exercise testing and prescription. 8thed. 2010 American College of Sports Medicine.
  28. Besse-Patin A, Montastier E, Vinel C, Castan-Laurell I, Louche K, Dray C, et al. Effect of endurance training on skeletal muscle myokine expression in obese men: identification of apelin as a novel myokine. International Journal of Obesity (Lond) 2014 ; 38(5): 707-13.
  29. Hittel DS, Axelson M, Sarna N, Shearer J, Huffman KM, Schifer AD, et al. Myostatin decreases with aerobic exercise and associates with insuling resistance. Medicine & Science in Sports & Exercise2010; 42: 2023-2029.
  30. Roustai, Mehdi, Gayini, Abbas Ali, Kurdi, Mohammad Reza. Differential measurement of myostatin gene expression in slow and fast twitch muscles of male rats after 8 weeks of very intense interval training. Sports Physiology and Physical Activity Journal 2015; 9(1): 1301-1306. doi: 10.48308/joeppa.2016.98787.
  31. Roth S M, Martel G F, Ferrell R E, Metter EJ , Hurley B F, Rogers M A, et al. Myostatin gene expression is reduced in humans with heavy-resistance strength training: a brief communication. Experimental Biology and Medicine 2003; 228: 706-9.
  32. Willoughby D, Taylor L. Effects of concentric and eccentric muscle action on Serum myostatin and follistatin-like related gene levels. Journal of Sports Science and Medicine 2004 ; 3: 226 – 233.
  33. Hulmi JY, Ahtiainen J, Kaasalainen T, Pollanen E. Post exercise myostatin and activin IIb mRNA levels: effects of strength training. Medicine & Science in Sports & Exercise 2007; 39: 289 –297.
  34. Kim JS1, Petrella JK, Cross JM, Bamman MM. Load-mediated downregulation of myostatin mRNA is not sufficient to promote myofiber hypertrophy in humans. Journal of Applied Physiology 2007; 103(5): 1488-95.
  35. Jensky NE, Sims JK, Dieli-Conwright CM, Sattler FR, Rice JC, Schroeder ET, et al. Exercise does not influence myostatin and follistatin mRNA expression in young women. Journal of Strength and Conditioning Research 2010; 24(2): 522.
  36. Udy G B, Towers R P, Snell R G, Wilkins R J, Park S H, Ram P A, et al. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proceedings of the National Academy of Sciences 1997; 94(14): 7239-44.
  37. Knuth CM, Peppler WT, Townsend LK, Miotto PM, Gudiksen A, Wright DC. Prior exercise training improves cold tolerance independent of indices associated with non-shivering thermogenesis. Journal of Physiology 2018; 596:4375–91.
  38. Boutcher S H. High-Intensity Intermittent exercise and Fat Loss. Journal of Obesity 2011: 1-10.
  39. Barnett C, Carey M, Proietto J, Cerin E, Febbraio MA, Jenkins D, et al. Muscle metabolism during sprint exercise in man: Influence of sprint training. Journal of Science and Medicine in Sport 2004; 7(3): 314-22.
  40. Yamaner F, Bayraktaroğlu T, Atmaca H, Ziyagil MA,Tamer K. Serum leptin, lipoprotein levels, and glucose homeostasis, between national wrestlers and sedentary males. Journal of Medical Sciences 2010; 40(3): 471-77.
  41. Stanford KI, Middelbeek RJ, Goodyear LJ. Exercise effects on white adipose tissue: beiging and metabolic adaptations. Diabetes 2015; 64: 2361–2368.
  42. Tsiloulis T, Carey AL, Bayliss J, Canny B, Meex RCR, Watt MJ. No evidence of white adipocyte browning after endurance exercise training in obese men. International Journal of Obesity(Lond) 2018; 42:721–7.
دانشور پزشکی
دوره 32، شماره 4 - شماره پیاپی 173
مهر و آبان 1403
صفحه 23-35

فایل ها

هم رسانی

ارجاع به این مقاله

آمار