مقدمه و هدف:بیماری آترواسکلروزیس یکی از شایع ترین علل مرگ و میر در جوامع مختلف است که در نتیجه آترواسکلروز سرخرگ های کرونر اتفاق می افتد و این عارضه در برخی از مراحل زندگی تشدید می یابد که یکی از این مراحل دوره یائسگی می باشد. در این مرحله ﺑﻪ دﻟﯿﻞ ﮐﺎﻫﺶ ﻓﯿﺰﯾﻮﻟﻮژﯾﮏ ﺳﻄﻮح اﺳﺘﺮوژن و اﯾﺠﺎد ﭼﺎﻗﯽ آﻧﺪروﺋﯿﺪ، اﻓﺰاﯾﺶ ﻓﻌﺎﻟﯿﺖ ﺳﯿﺴﺘﻢ ﺳﻤﭙﺎﺗﯿﮏ، ﻧﻘﺺ در ﻋﻤﻠﮑﺮد و اﮐﺴﯿﺪاﺳﯿﻮن ﭼﺮﺑﯽﻫﺎ، اﺧﺘﻼل درﻋﻤﻠﮑﺮد اﻧﺪوﺗﻠﯿﺎل و اﻟﺘﻬﺎب ﻋﺮوﻗﯽ اﺣﺘﻤﺎل اﺑﺘﻼ ﺑﻪ ﺑﯿﻤﺎریﻫﺎی ﻗﻠﺒﯽ-ﻋﺮوﻗﯽ را در زﻧﺎن ﯾﺎﺋﺴﻪ اﻓﺰاﯾﺶ ﻣﯽیابد. یکی از عوامل کاهش خطر آترواسکلروزیس بیان ATP-binding cassette transporter (ABCA) mRNA expression است که در انتقال معکوس کلسترول نقش دارد. هدف از مطالعه حاضر بررسی تاثیر تمرین هوازی بر بیان mRNA ABCA1 در سلول های PBMC می باشد. مواد و روش ها: این مطالعه بر روی 30 نفر زن یائسه به صورت تصادفی در دو گروه کنترل و گروه هشت هفته تمرین هوازی انجام شد. سپس قبل و بعد از مداخله از همه آزمودنیها cc10 خونگیری به عمل آمد و جدا سازی لنفوسیتها به روش سانتریفیوژ و تلخیص mRNAبه وسیله دستگاه PCRانجام و اطلاعات حاصل توسط تحلیل کوواریانس در سطح معنیداری (P≤0.05) و تعقیبی بونفرونی جهت بررسی بین گروه ها در محیط SPSS19 تحلیل شد. نتایج:داده ها نشان داد تمرین هوازی در بیان ژنABCA1 و HDL و LDLو APO-A1تاثیر معنیداری داشته است. (P ≤0.05). نتیجهگیری:براساس یافتههای تحقیق میتوان نتیجهگیری نمود که هشت هفته تمرین هوازی باعث بهبود انتقال معکوس کلسترول و پیشگیری از بیماری آترواسکلروزیس در زنان یائسه می شود .
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