دانشور پزشکی

دانشور پزشکی

تأثیر یک دوره تمرین تناوبی با شدت بالا همراه با رژیم غذایی پرچرب بر بیان ماکروفاژهای M1و M2 در عضله گاستروکنمیوس موش های بزرگ نر نژاد ویستار

نوع مقاله : مقاله پژوهشی

نویسندگان
علیرضا فتاحیان 1
محمد رضا کردی 1
علی اصغر رواسی 1
رضا قراخانلو 2
1 گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی و تندرستی، دانشگاه تهران، تهران، ایران
2 گروه فیزیولوژی ورزشی، دانشکده علوم انسانی، دانشگاه تربیت مدرس، تهران، ایران
10.22070/daneshmed.2024.19291.1510
چکیده
مقدمه و هدف: فعالیت ورزشی در جنبه‌های مختلفی مانند سیستم عضلانی بررسی می‌شود. این پژوهش به بررسی تأثیر یک دوره تمرین تناوبی شدت بالا همراه با رژیم غذایی پرچرب بر بیان ماکروفاژهای M1 و M2 در عضله گاستروکنمیوس رت‌های نر نژاد ویستار می‌پردازد.
مواد و روش ها: تعداد ٢٤ سررت نر بالغ سالم نژاد ویستار با میانگین وزن 15±195 گرم و سن 6 هفته به‌طور تصادفی به ٤ گروه کنترل، تمرین تناوبی با شدت بالا، تغذیه پرچرب و تمرین تناوب با شدت بالا با تغذیه پرچرب تقسیم شدند. مداخلات، شامل 10 هفته تمرینات تناوبی با شدت بالا و تغذیه پرچرب بود. سپس، نمونه‌برداری از عضله گاستروکنمیوس انجام شد. مقادیر ماکروفاژهای M1 و M2 با استفاده از روش Real-Time-PCR اندازه‌گیری شد. تجزیه تحلیل داده­ با استفاده از تحلیل واریانس یک­طرفه در سطح معنی­داری) 05/0P<) انجام شد.
اختلاف معنی‌داری بین گروه‌ها در بیان ماکروفاژهای M1  (0004/0P=) و M2 (0023/0P=) مشاهده شد. بیان ماکروفاژ M1 در گروه تغذیه پرچرب نسبت به گروه تمرین تناوبی با شدت بالا به‌طور معنی‌داری بالاتر (0001/0=P) بود. بیان ماکروفاژ M1 در گروه تمرین تناوبی با شدت بالا با تغذیه پرچرب نسبت به گروه تغذیه پرچرب به طورمعنی­داری کمتربود (0001/0P=)، اما بیان ماکروفاژ M2 درگروه تمرین تناوبی با شدت بالا با تغذیه پرچرب نسبت به گروه تغذیه پرچرب به طورمعنی­داری بالاتر (0003/0=P) بود.
نتیجه‌گیری: با توجه به نتایج به نظر می‌رسد تمرینات تناوبی با شدت بالا می‌تواند بیان ماکروفاژهای M1 را کاهش و ماکروفاژهای M2 را افزایش دهد و از اثرات منفی تغذیه پرچرب جلوگیری کند.
کلیدواژه‌ها
تمرین تناوبی با شدت بالا
رژیم غذایی پرچرب
ماکروفاژ M1
ماکروفاژ M2
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دانشور پزشکی
دوره 32، شماره 3 - شماره پیاپی 172
مرداد و شهریور 1403
صفحه 80-94