دانشور پزشکی

دانشور پزشکی

اثر تعاملی تمرین مقاومتی کل بدن (TRX) و مصرف خوراکی عصاره برگ درخت انبه بر سطوح سرمی اینترلوکین-12 و برخی شاخص های آنترپرومتریکی دانشجویان پسر دارای اضافه وزن و چاق

نوع مقاله : کاربردی

نویسندگان
امید محمددوست
فاطمه شب خیز
علی اکبرنژاد قره لو
گروه فیزیولوژی فعالیت ورزشی، دانشکده علوم ورزشی و تندرستی، دانشگاه تهران، تهران، ایران
10.22070/daneshmed.2024.19194.1502
چکیده
مقدمه و هدف: فعالیت بدنی بر التهاب اثر دوگانه دارد، در هیمن راستا نتایج مطالعات بسیار متناقض است. لذا هدف پژوهش حاضر، اثر تعاملی شش هفته تمرین مقاومتی کل بدن (TRX) و مصرف خوراکی عصاره برگ درخت انبه بر اینترلوکین-12 و شاخص­های آنترپرومتریکی دانشجویان پسر دارای اضافه­وزن و چاق غیرفعال بود.
مواد و روش ها: در این پژوهش نیمه تجربی، 48 دانشجوی پسر دارای اضافه وزن و چاق غیرفعال با دامنه سنی 25-20 سال به صورت هدفمند انتخاب و در چهار گروه 12 نفره : کنترل، عصاره، تمرین و تمرین+عصاره        تقسیم بندی شدند. شش هفته (سه جلسه در هفته) به انجام تمرین TRX و مصرف روزانه 2 بار کپسول 500       میلی گرمی حاوی عصاره برگ انبه بعد از صرف نهار و شام پرداختند. نمونه گیری خونی، 24 ساعت قبل و 48 ساعت متعاقب آخرین جلسه تمرین انجام گرفت. سطح سرمی اینترلوکین-12 به روش الیزا با استفاده از کیت انسانی اندازه گیری شد. داده ها با آزمون تی وابسته و تحلیل واریانس یکراهه و سطح معناداری کمتر از 05/0 در نرم افزار SPSS-25 تحلیل شدند(05/0>P).
نتایج: تفاوت معناداری در سطوح اینترلوکین-12، گروه­های تمرین، تمرین+ عصاره و عصاره نسبت به پیش آزمون مشاهده شد(p=0.001). اختلاف پیش و پس آزمون گروه­ها با استفاده از تحلیل واریانس یکراهه بر روی وزن، درصد چربی، شاخص توده بدنی و سطوح اینترلوکین-12 در بین گروه­های پژوهش تفاوت معناداری نشان داد (05/0>p بین گروهی).
نتیجه‌گیری: شش هفته تمرین مقاومتی کل بدن (TRX) و مصرف عصاره برگ انبه، ممکن است در کاهش وزن، درصد چربی، شاخص توده بدنی و سطوح سرمی اینترلوکین-12 موثر می باشد. از طرفی یکی از راه های کنترل التهاب، انجام تمرین  TRXبه همراه عصاره برگ انبه است.
کلیدواژه‌ها
تمرین مقاومتی کل بدن (TRX)
عصاره برگ انبه
اینترلوکین- 12
اضافه وزن و چاقی
  1. Nammi S, Koka S, Chinnala KM, Boini KM. Obesity: an overview on its current perspectives and treatment options. Nutrition Journal 2004;3(1):3-9.
  2. Mokdad AH, Ford ES, Bowman BA, Dietz WH, Vinicor F, Bales VS, et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. Journal of the American Medical Association 2003;289(1):76-79.
  3. Bhatt DL, Steg PG, Ohman EM, Hirsch AT, Ikeda Y, Mas J-L, et al. International prevalence, recognition, and treatment of cardiovascular risk factors in outpatients with atherothrombosis. Journal of the American Medical Association 2006;295(2):180-1189.
  4. Rahimi A, Hojjat S, Besharati A, Shokrgozar A, Masoumi S. The effect of an Aerobic exercise on IL6, CRP and TNFα concentration in women. Annals of Biological Research 2012;3(1):125-131.
  5. Patel A. The role of inflammation in depression. Psychiatr Danub 2013;25(2):216-223.
  6. Frank L, Hat Faludy Z. Peter Konitsm. Sportovosis Zemele Hungrian Review of Sport Medicine 1991;32(2):58-9.
  7. Delavar A. Statistical methods in psychology and educational sciences. Tehran, Payam Noor University Publications 1377:118-126.
  8. Dolati M, Ghazalian F, Abednatanzi H. The effect of a period of TRX training on lipid profile and body composition in overweight women. International Journal Sport Sciences 2017;7(1):151-158.
  9. Pastucha D, Filipcikova R, Bezdickova M, Blazkova Z, Oborna I, Brezinova J, et al. Clinical anatomy aspects of functional 3D training--case study. Biomed Pap Medicine Fac University Palacky Olomouc Czech Repub 2012;156(1):63-69.
  10. Aversa R, Petrescu RV, Apicella A, Petrescu FI. One can slow down the aging through antioxidants. American Journal of Engineering and Applied Sciences 2016;9(2):14-28.
  11. Kumar M, Saurabh V, Tomar M, Hasan M, Changan S, Sasi M, et al. Mango (Mangifera indica L.) leaves: Nutritional composition, phytochemical profile, and health-promoting bioactivities. Antioxidants 2021;10(2):299-310.
  12. Zhu L, Hu W, Murtaza A, Iqbal A, Li J, Zhang J, et al. Eugenol treatment delays the flesh browning of fresh-cut water chestnut (Eleocharis tuberosa) through regulating the metabolisms of phenolics and reactive oxygen species. Food Chemistry 2022;14(3):100-130.
  13. Noratto GD, Bertoldi MC, Krenek K, Talcott ST, Stringheta PC, Mertens-Talcott SU. Anticarcinogenic effects of polyphenolics from mango (Mangifera indica) varieties. Journal of Agricultural and Food Chemistry 2010;58(7):4104-4112.
  14. Pardo-Andreu GL, Paim BA, Castilho RF, Velho JA, Delgado R, Vercesi AE, et al. Mangifera indica L. extract (Vimang®) and its main polyphenol mangiferin prevent mitochondrial oxidative stress in atherosclerosis-prone hypercholesterolemic mouse. Pharmacological Research 2008;57(5):332-338.
  15. Mwaurah PW, Kumar S, Kumar N, Panghal A, Attkan AK, Singh VK, et al. Physicochemical characteristics, bioactive compounds and industrial applications of mango kernel and its products: A review. Comprehensive Reviews in Food Science and Food Safety 2020;19(5):2421-2446.
  16. Barreto JC, Trevisan MT, Hull WE, Erben G, De Brito ES, Pfundstein B, et al. Characterization and quantitation of polyphenolic compounds in bark, kernel, leaves, and peel of mango (Mangifera indica L.). Journal of Agricultural and Food Chemistry 2008;56(14):5599-5610.
  17. Sferrazzo G, Palmeri R, Restuccia C, Parafati L, Siracusa L, Spampinato M, et al. Mangifera indica L. Leaves as a potential food source of phenolic compounds with biological activity. Antioxidants 2022;11(7):131-133.
  18. Haqiqi A, Ravasi A, Gaini A, Aminian Razavi T, Hamedi Nia M. The effect of resistance training on cytokines associated with inflammation and insulin resistance in obese men. Olympic Magazine 1385;14(2):19-29.
  19. Chen F, Wang N, Tian X, Su J, Qin Y, He R, et al. The protective effect of mangiferin on formaldehyde-induced HT22 cell damage and cognitive impairment. Pharmaceutics 2023;15(6):156-158.
  20. Lum PT, Sekar M, Gan SH, Jeyabalan S, Bonam SR, Rani NNIM, et al. Therapeutic potential of mangiferin against kidney disorders and its mechanism of action: A review. Saudi Journal of Biological Sciences 2022;29(3):1530-1542.
  21. Peake J, Wilson G, Hordern M, Suzuki K, Yamaya K, Nosaka K, et al. Changes in neutrophil surface receptor expression, degranulation, and respiratory burst activity after moderate-and high-intensity exercise. Journal of Applied Physiology 2004;97(2):612-618.
  22. Mooren FC, Bloming D, Lechtermann A, Lerch MM, Volker K. Lymphocyte apoptosis after exhaustive and moderate exercise. Journal of Applied Physiology 2002;93(1):147-153.
  23. Gielen S, Adams V, Möbius-Winkler S, Linke A, Erbs S, Yu J, et al. Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. Journal of the American College of Cardiology 2003;42(5):861-868.
  24. Adamopoulos S, Parissis J, Kroupis C, Georgiadis M, Karatzas D, Karavolias G, et al. Physical training reduces peripheral markers of inflammation in patients with chronic heart failure. European Heart Journal 2001;22(9):791-797.
  25. Nicklas BJ, Ambrosius W, Messier SP, Miller GD, Penninx BW, Loeser RF, et al. Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial. The American Journal of Clinical Nutrition 2004;79(4):544-551.
  26. Bruunsgaard H, Bjerregaard E, Schroll M, Pedersen BK. Muscle strength after resistance training is inversely correlated with baseline levels of soluble tumor necrosis factor receptors in the oldest old. Journal of the American Geriatrics Society 2004;52(2):37-41.
  27. Shariatzadeh Junidi M, Moghadam Z, Maleki L, Keshavarz A, Hedayati M. Short-term effect of two types of high-intensity interval training on plasma levels of TNF-α, IL-6, CRP and lipid profile in overweight women. Sports Biology Journal 2017;9(2):195-207. Persian.
  28. Mosaferi-Ziaaedini M, Ebrahin K, Amani D, Arabnarmi Z. Effect of supplementary consumption of coenzyme Q10 on TNF-α serum levels during maximal training. Journal Ardabil University Medicine Science 2012;12(3):303-311.
  29. Baravati S, Mogharnasi M, Badiakhar H, Rahimi E. Response and compatibility of plasma levels of Nesfatin-1, glucose and insulin resistance index to circuit resistance training in obese disabled men. Institute of Integrative Omics and Applied Biotechnology Journal 2016; 7(8): 74-81.
  30. Vahidian-Rezazadeh M, Ghaed Rahmati A, Mazaheri M. Effect of TRX Training on Serotonin, Happiness and Army Physical Fitness Test (APFT) Scores of Border Guard’s Soldiers in Sistan and Baluchestan Province, South-West of Iran. Journal Military Medicine 2020; 22(4):183-92.Persian.
  31. Riche DM, Riche KD, East HE, Barrett EK, May WL. Impact of mulberry leaf extract on type2diabetes (Mul-DM): a randomized, placebo-controlled pilot study. Complement Theran Medicine 2017; 32: 105-108.
  32. Aliniya N, Elmieh A, Fadaei Chafy MR. Interaction effect of combined exercise and supplementation with portulaca oleracea on liver enzymes in obese postmenopausal women withnon-alcoholic fatty liver disease. Complement Medicine Journal 2020; 10(1):68-79.
  33. Faraji H, Mmirahmad F, Mahammadi A. The effect of strawberry extract supplementation on some oxidative, inflammatory and cellular damage indicators after a session of exhausting resistance exercise in non-athlete women. Research in Exercise Nutrition 2022;1(2):1-10.
  34. Alimoradi N, Nourollahi H, Hosseini F. The effect of eight weeks of TRX and CRX exercising on body composition and lipid profile indices in overweight young women. Journal of Physiologh of Movement & Health 2022;2(1):29-40.
  35. Kondori BJ, Ghaleh HEG, Hosseini SM. Effect of green tea extract on exercise-induced inflammatory markers. Journal of Military Medicine 2021;23(2):24-35.
  36. Jabbari S, Kargarfard M. Short-term effect of Quercetin supplementation on inflammatory and oxidative stress indices of active individuals after intense exercise. Journal of Applied Health Studies in Sport Physiology 2021;8(1):36-43.
  37. Valeh S, Fatolahi H, Azarbayjani MA. Effect of eight weeks of low, moderate, and high-intensity TRX training on hot flashes, mood, fat percentage, and muscular endurance in postmenopausal women. Apunts Sports Medicine 2020;55(207):97-103.
  38. Monazami a. Determining the effect of simultaneous exercise on the response of pro-inflammatory factors in postmenopausal women with breast cancer. The first national sports science conference with the approach of engineering technical sciences: Ministry of Science, Research and Technology - Isfahan University of Technology 2018.
  39. Dolati M, Ghazalian F, Abednatanzi H. The effect of a period of TRX training on lipid profile and body composition in overweight women. International Journal Sport Science 2017;7:151-158.
  40. Uchio R, Okuda-Hanafusa C, Sakaguchi H, Saji R, Muroyama K, Murosaki S, et al. Curcuma longa extract reduces serum inflammatory markers and postprandial hyperglycemia in healthy but borderline participants with overweight and glycemia in the normal/prediabetes range: a randomized, double-blind, and placebo-controlled trial. Frontiers in Nutrition 2024;11:(13):241-296.
  41. Lesmana R, Setiawan FCB, Mukaromah SB, Goenawan H, Tarawan VM, Kusumawati M, et al. The Influence of Aquarobic Training Towards Interleukin 12 (IL-12) Plasma Level and Its Correlation with Obesity. The Open Sports Sciences Journal 2020;13(1):147-156.
  42. Oh D-H, Lee J-K. Effect of different intensities of aerobic exercise combined with resistance exercise on body fat, lipid profiles, and adipokines in middle-aged women with obesity. International Journal of Environmental Research and Public Health 2023;20(5):3991.
  43. Rejeki PS, Pranoto A, Rahmanto I, Izzatunnisa N, Yosika GF, Hernaningsih Y, et al. The Positive Effect of Four-Week Combined Aerobic–Resistance Training on Body Composition and Adipokine Levels in Obese Females. Sports 2023;11(4):90-97.
  44. Lopez P, Radaelli R, Taaffe DR, Galvão DA, Newton RU, Nonemacher ER, et al. Moderators of Resistance Training Effects in Overweight and Obese Adults: A Systematic Review and Meta-analysis. Medicine and science in sports and exercise. 2022.
  45. Wang Y-H, Luo D-L, Jiang H-C, Nie Z-B, Shao L, Qi H-X. Effects of aerobic exercise on inflammatory factors in healthy adults: a meta-analysis. European Review for Medical & Pharmacological Sciences 2022;26(12):12-19.
  46. Ribeiro B, Forte P, Vinhas R, Marinho DA, Faíl LB, Pereira A, et al. The benefits of resistance training in obese adolescents: a systematic review and meta-analysis. Sports Medicine-Open 2022;8(1):109.
  47. Lesmana R, Setiawan FCB, Mukaromah SB, Goenawan H, Tarawan VM, Kusumawati M, et al. The Influence of Aquarobic Training Towards Interleukin 12 (IL-12) Plasma Level and Its Correlation with Obesity. The Open Sports Sciences Journal 2020;13(1):17.
  48. Hosseini Zadeh A. The effect of an endurance training course on tissue interleukin 12 (IL-12) levels and tissue tumor volume of mice with breast cancer: Islamic Azad University - Islamic Azad University, Central Tehran Branch - Faculty of Physical Education and Sports Sciences; 2013.
  49. Kang B, Song Y, Kim KM, Choe YK, Hwang S, Kim TS. Curcumin inhibits Th1 cytokine profile in CD4+ T cells by suppressing interleukin‐12 production in macrophages. British Journal of Pharmacology 1999;128(2):380-384.
  50. Tsai J-L, Priya TJ, Hu K-Y, Yan H-Y, Shen S-T, Song Y-L. Grouper interleukin-12, linked by an ancient disulfide-bond architecture, exhibits cytokine and chemokine activities. Fish & Shellfish Immunology 2014;36(1):27-37.
  51. Su W, Ito T, Oyama T, Kitagawa T, Yamori T, Fujiwara H, et al. The direct effect of IL-12 on tumor cells: IL-12 acts directly on tumor cells to activate NF-κB and enhance IFN-γ-mediated STAT1 phosphorylation. Biochemical and Biophysical Research Communications 2001;280(2):503-512.
  52. Taghavi K, Farnia P, Anousheh S, Bayat M, Kazempour M, Masjidi M. Comparison of serum levels of α-TNF, interleukin-10, interleukin-12 and interferon gamma in diseases caused by Mycobacterium tuberculosis and non-tuberculosis. Scientific Research Journal of Shahid Sadoughi University of Medical Sciences 2010;18(4):355-360.
  53. FereshtF. Effect of garlic extract on interleukin-12 and interleukin-10 levels of leishmaniasis-infected macrophages. Qom University of Medical Sciences 2011;5(1):83-90.
  54. Ehsan Bakhshian D, Sheikh Shahrokhi d. Investigation of serum levels of interleukin 12 in patients with latent hepatitis B infection in Chaharmahal and Bakhtiari province.The First International Congress and the 13th Iranian Genetic Congress 2014.
  55. Payande A, Momenpour R, Alipour A, Yari Kh, Payende M. Determining the effect of simultaneous exercise on the response of inflammatory agents in postmenopausal women with breast cancer. First National Conference on Sports Science with the Approach of Engineering Technical Sciences: Ministry of Science, Research and Technology - Isfahan University of Technology 2018.
  56. Rhind SG, Castellani JW, Brenner IK, Shephard RJ, Zamecnik J, Montain SJ, et al. Intracellular monocyte and serum cytokine expression is modulated by exhausting exercise and cold exposure. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2001;281(1):66-75.
  57. Andersson J, Jansson J-H, Hellsten G, Nilsson TK, Hallmans G, Boman K. Effects of heavy endurance physical exercise on inflammatory markers in non-athletes. Atherosclerosis 2010;209(2):601-605.
  58. Germanou EI, Chatzinikolaou A, Malliou P, Beneka A, Jamurtas AZ, Bikos C, et al. Oxidative stress and inflammatory responses following an acute bout of isokinetic exercise in obese women with knee osteoarthritis. The Knee 2013;20(6):581-590.
  59. Jaydari F, Johari H, Taati M, Asadian P, Alirezaei M, Sheikhzadeh F. The effects of fruit extract on catalase activity and lipid peroxidation in the heart and erythrocytes of rats following chronic ethanol consumption. Journal of Veterinary Research 2011;3 (2):179-183.
دانشور پزشکی
دوره 32، شماره 2 - شماره پیاپی 171
خرداد و تیر 1403
صفحه 21-38