اثر دیمینازین بر هایپرتروفی قلبی از طریق بهبود هایپرلیپیدمی در موش های سفید بزرگ آزمایشگاهی مدل پیری ناشی از د-گالاکتوز

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشکده پزشکی، دانشگاه علوم پزشکی همدان، همدان، ایران

2 گروه قلب و عروق، دانشکده پزشکی، دانشگاه علوم پزشکی همدان، همدان، ایران

3 گروه فیزیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی همدان، همدان، ایران

4 گروه علوم اعصاب، دانشکده علوم و فناوری پیشرفته در پزشکی، دانشگاه علوم پزشکی همدان، همدان، ایران

چکیده

مقدمه و هدف: افزایش سن نقش مهمی در بیماری های قلبی عروقی دارد. دیمینازین یک داروی ضد عفونت دامی است که اثرات محافظتی بر بیماری های قلبی عروقی دارد. این مطالعه با هدف بررسی اثرات محافظتی قلبی احتمالی دیمینازین در موش های سفید بزرگ آزمایشگاهی مدل پیری ناشی از د-گالاکتوز از طریق بهبود لاکتات دهیدروژناز (LDH) و کراتین کیناز قلبی (CK-MB) و پروفایل لیپیدی انجام شد.
مواد و روش ها: 20 سر موش سفید بزرگ آزمایشگاهی نر نژاد ویستار به طور مساوی به گروه‌های کنترل،  دیمینازین(DIZE)، د-گالاکتوز (D-GAL) و D-GAL+DIZE تقسیم شدند . هایپرتروفی قلب اندازه گیری شد. سطح سرمی پروفایل لیپیدی و نشانگرهای آسیب قلبی اندازه گیری شد.
نتایج: افزایش سن باعث دیس‌لیپیدمی همراه با هایپرتروفی قلبی و افزایش معنی‌دار LDH و CK-MB سرم شد. درمان  با  دیمینازین در موش های سفید بزرگ آزمایشگاهی پیر باعث بهبود قابل توجهی در هایپرتروفی قلبی و نشانگرهای قلبی شد. این را می توان با توانایی دیمینازین دربهبود سطوح تری گلیسرید(TG) ، لیپوپروتئین با چگالی بسیار کم (VLDL) و لیپوپروتئین با چگالی بالا (HDL) توضیح داد.
نتیجه‌گیری: دیمینازین  اثر محافظتی قلبی در پیری، عمدتاً با بهبود هایپرتروفی قلبی و دیس‌لیپیدمی دارد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Effect of diminazene on cardiac hypertrophy through improving hyperlipidemia in D-galactose-induced aging rats

نویسندگان [English]

  • Ali Mohammadi 1
  • Farnaz Fariba 2
  • Siamak Shahidi 3
  • Abdolrahman Sarihi 4
  • Fatemeh Ramezani-Aliakbari 3
1 Medical School, Hamadan University of Medical Sciences, Hamadan, Iran
2 Department of Cardiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3 Department of Physiology, School of medicine, Hamadan University of Medical Sciences, Hamadan, Iran
4 Department of Neuroscience, School of Sciences and Advanced Technology in Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
چکیده [English]

Background and Objective: Aging plays an important role in cardiovascular diseases. Diminazine is an animal anti-infective drug that has protective effects on cardiovascular diseases. This study aimed to investigate the possible cardio-protective effects of Diminazine in aged rats induced by D-galactose through improving lactate dehydrogenase (LDH), and cardiac creatine kinase (CK-MB), and lipid profile.
Materials and Methods: 20 male Wistar rats were divided equally into control, Diminazine (DIZE), D-galactose (D-GAL), and D-GAL+DIZE groups. Cardiac hypertrophy was measured. Serum levels of lipid profile and cardiac damage markers were also measured.
Results: Aging caused dyslipidemia with cardiac hypertrophy and significant increases in serum LDH, and CK-MB. Diminazine treatment of aged rats induced significant improvements in cardiac hypertrophy and cardiac markers. This could be explained by the ability of Diminazine to improve triglyceride (TG), very low density lipoprotein (VLDL), and high density lipoprotein (HDL) levels.
Conclusion: Diminazine exerts a cardio-protective effect in aging, mainly by improving cardiac hypertrophy and dyslipidemia.

کلیدواژه‌ها [English]

  • Aging
  • Diminazine
  • Heart
  • Hypertrophy

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دانشور پزشکی
دوره 32، شماره 2 - شماره پیاپی 171
خرداد و تیر 1403
صفحه 86-97

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