نوع مقاله : مقاله پژوهشی
نویسندگان
1 دانشکده پزشکی، دانشگاه علوم پزشکی همدان، همدان، ایران
2 گروه قلب و عروق، دانشکده پزشکی، دانشگاه علوم پزشکی همدان، همدان، ایران
3 گروه فیزیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی همدان، همدان، ایران
4 گروه علوم اعصاب، دانشکده علوم و فناوری پیشرفته در پزشکی، دانشگاه علوم پزشکی همدان، همدان، ایران
چکیده
کلیدواژهها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Background and Objective: Aging plays an important role in cardiovascular diseases. Diminazine is an animal anti-infective drug that has protective effects on cardiovascular diseases. This study aimed to investigate the possible cardio-protective effects of Diminazine in aged rats induced by D-galactose through improving lactate dehydrogenase (LDH), and cardiac creatine kinase (CK-MB), and lipid profile.
Materials and Methods: Twenty male Wistar rats were divided equally into control, Diminazine (DIZE), D-galactose (D-GAL), and D-GAL+DIZE groups. Cardiac hypertrophy was measured. Serum levels of lipid profile and cardiac damage markers were measured.
Results: Aging caused dyslipidemia with cardiac hypertrophy and significant increases in serum LDH, and CK-MB. Diminazine treatment of aged rats induced significant improvements in cardiac hypertrophy and cardiac markers; this could be explained by the ability of Diminazine to improve triglyceride (TG), very low density lipoprotein (VLDL), and high density lipoprotein (HDL) levels.
Conclusion: Diminazine exerts a cardio-protective effect in aging, mainly by improving cardiac hypertrophy and dyslipidemia.
کلیدواژهها [English]