اثر تمرینات تناوبی شنا بر بیان ژن هیپوکامپی برخی عوامل التهابی در موش‌های صحرایی مبتلا به بیماری پارکینسون

نوع مقاله : مقاله پژوهشی

نویسندگان

1 گروه علوم ورزشی، واحد شیراز، دانشگاه آزاد اسلامی، شیراز، ایران

2 گروه زیست‌شناسی، واحد شیراز، دانشگاه آزاد اسلامی، شیراز، ایران

چکیده

مقدمه و هدف: بیماری پارکینسون یک بیماری پیش‌رونده سیستم عصبی است که علاوه بر سیستم عصبی مرکزی، دیگر اعضای بدن را نیز تحت تأثیر قرار می‌دهد. مطالعه حاضر با هدف بررسی اثر یک دوره تمرین تناوبی شنا با شدت بالا بر بیان ژن هیپوکامپی برخی عوامل التهابی در موش‌های صحرایی مبتلا به پارکینسون انجام شد.
مواد و روش ها: در مطالعه تجربی حاضر، 21 سر موش نر صحرایی نژاد ویستار 10 -8 هفته‌ای با میانگین وزن 2/10 ± 200 گرم به‌طور تصادفی در سه گروه کنترل سالم، بیمار و تمرین شنا قرار گرفتند. القای بیماری به‌واسطه تزریق 1 میلی‌گرم به ازای هر کیلو وزن بدن رزرپین و طی 5 روز صورت گرفت. گروه تمرین به مدت شش هفته 20 نوبت 30 ثانیه‌ای شنا با 30 ثانیه استراحت بین هر نوبت انجام دادند. نتایج با استفاده از تحلیل واریانس یک‌راهه و آزمون تعقیبی LSD در سطح معنی‌داری 05/0>P مورد تجزیه و تحلیل قرار گرفتند.
نتایج: نتایج نشان داد بیان ژن هیپوکامپی TNF-α پس از اجرای تمرینات تناوبی شنا در گروه تمرین نسبت به گروه بیمار (01/0=p) به‌طور معنی‌داری کاهش داشته است درحالی‌که علی‌رغم پایین‌تربودن بیان ژن IL-1β در گروه تمرین نسبت به گروه بیمار، اما این کاهش معنی‌دار نبود (6/0=p).
نتیجه‌گیری: با توجه به نتایج به‌دست‌آمده اجرای تمرینات تناوبی شنا با شدت بالا در کاهش بیان ژن برخی عوامل التهابی در بافت هیپوکامپ موش‌های مبتلا به پارکینسون مؤثر است و ممکن است به این واسطه به بهبود روند بیماری کمک کند.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The effect of high intensity swimming interval training on gene expression of some hippocampal inflammatory markers in rats with Parkinson's disease

نویسندگان [English]

  • Mehrzad Moghadasi 1
  • Reza Zeinolebadi 1
  • Mohammadamin Edalatmanesh 2
  • Mehdi Noora 1
1 Department of exercise physiology, Shiraz branch, Islamic Azad University, Shiraz, Iran
2 Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
چکیده [English]

Background and Objective: Parkinson disease (PD) is a progressive neurodegenerative disease that affects peripheral organs as well as the central nervous system (CNS). The present study was done to examine the effect of high intensity swimming interval training on gene expression of some hippocampal inflammatory markers in rats with PD.
Materials and Methods: In this experimental study, 21 male Wistar rats (aged 8-10 weeks; weight 200 ± 10.2 grams) were divided into three groups including: healthy control, PD and training. PD was induced by injection of 1 mg/kg of reserpine during 5 days. The rats in the training group performed 6 weeks of HIIT including 20 times of 30 seconds of swimming with 30 seconds of rest between each time. Data were analyzed using one-way ANOVA and LSD post hoc test were run using SPSS-22 at the P <0.05.
Results: Data revealed that TNF-α gene expression was reduced after 6 weeks of swimming interval training (p=0.01) compared to the PD group. We observed non-significant decrease in IL-1β after the intervention as compared to the PD group (p=0.6).
Conclusion: According the results of this study, high intensity swimming interval training is effective in reducing the gene expression of some hippocampal inflammatory markers in rats with PD and it is suggested as the effective strategy to improve PD.

کلیدواژه‌ها [English]

  • Swimming interval training
  • Parkinson’s disease
  • TNF-α
  • IL-1β

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دانشور پزشکی
دوره 31، شماره 6 - شماره پیاپی 169
بهمن و اسفند 1402
صفحه 37-45

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