تاثیر یک دوره طولانی مدت تمرینات ورزشی در منزل بر سایتوکاین های اینترلوکین 6 و اینترلوکین 17 و وضعیت بیماری در افراد مبتلا به بیماری ام اس

نوع مقاله : مقاله پژوهشی

نویسندگان

1 گروه تربیت بدنی و علوم ورزشی، دانشکده علوم انسانی، دانشگاه تربیت مدرس، تهران، ایران

2 پژوهشکده بازتوانی عصبی، دانشگاه علوم پزشکی تهران؛ تهران، ایران

چکیده

مقدمه و هدف: بیماری ام اس یک بیماری مرتبط با سیستم عصبی است که با نارسایی در پاسخ های سیستم ایمنی همراه است. فعالیت های ورزشی در فرایند درمان این بیماران مورد توجه بوده است. با توجه به اثرات شاخص های سیستم ایمنی به ویژه سایتوکاین در بیماری ام اس هدف از مطالعه حاضر بررسی تاثیر تمرینات ورزشی  ترکیبی در منزل بر سایتوکاین های اینترلوکین-6 (IL-6) و IL-17 در بیماران مبتلا به مالتیپل اسکلروزیس بود.
مواد و روش ها: 42 بیمار مبتلا به بیماری ام اس به صورت تصادفی به دو گروه آزمون و کنترل تقسیم شدند. آزمودنی های گروه تجربی، در یک دوره برنامه تمرینات ورزشی ترکیبی 6 ماهه در منزل شرکت کردند. قبل و بعد از دوره تمرین شاخص های خونی برای اندازه گیری سایتوکاین ها گرفته شد و وضعیت ناتوانی جسمانی توسعه یافته (EDSS) ارزیابی شد. از نرم افزار آماری SPSS برای تحلیل نتایج استفاده شد و سطح معناداری P<0.05 در نظر گرفته شد.
نتایج: پژوهش حاضر نشان داد که بهبود شاخص EDSS و بهبود در عملکرد راه رفتن مشاهده می شود (P<0.05). همچنین، سطوح سرمی سایتوکاین های التهابی IL-6 و IL-17 به صورت معناداری در گروه تمرین کاهش یافت (P<0.05).
نتیجه‌گیری: تمرینات ورزشی طولانی مدت در منزل با کاهش سایتوکاین های التهابی و بهبود عملکرد بیماران مبتلا به ام اس همراه بود. به نظر می رسد این نوع تمرینات ورزشی می تواند در بهبود احتمالی پاسخ های سیستم ایمنی به ویژه پاسخ های التهابی موثر باشد و به عنوان یک درمان مکمل در نظر گرفته شود.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The effect of long-term home-based exercise training on interleukin-6 and interleukin-17 cytokines and disease status in people with Multiple Sclerosis

نویسندگان [English]

  • Mehdi Hamzeh Shalamzari 1
  • Mahdieh Molanouri Shamsi 1
  • Maryam Aboulhasani 2
  • Motahare Mokhtarzade 1
  • Mojgan Rezvani 1
1 Department of Physical Education & Sport Sciences, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran
2 Multiple sclerosis Research Center, Neuroscience institute, Tehran University of Medical Sciences, Tehran, Iran
چکیده [English]

Background and Objective: Multiple sclerosis (MS) is related to the nervous system that is associated with chronic inflammation and failure of immune system responses. Exercise activities have been considered in the treatment process of MS patients. Considering the effects of immune system indices, especially cytokines in MS, this study aimed to evaluate the effect of combined exercise training at home on inflammatory cytokines including interleukin-6 (IL-6) and interleukin-6 (IL-17) in patients with MS.
Materials and Methods: 42 patients with MS were randomly divided into experimental and control groups. The subjects in the experimental group participated in a 6-month home-based combined exercise training, five times a week. Blood samples were taken for cytokines measurement. Also, developed physical disability status (EDSS), and gait-related performance were assessed before and after the exercise training. SPSS statistical software was used to analyze the results and the significance level was P<0.05.
Results: TThe present study showed an improvement in the EDSS index in people with MS, which coincides with an improvement in gait function (P <0.05). Moreover, serum levels of inflammatory cytokines IL-6 and IL-17 decreased significantly in the exercise group (P <0.05).
Conclusion: Prolonged exercise training at home was associated with a significant decrease in inflammatory cytokines and improved function in patients with MS. It seems that this type of exercise training can be effective in the possible improvement of immune system responses, especially inflammatory responses, and can be considered as a complementary therapy along with adjunctive therapies for these patients.

کلیدواژه‌ها [English]

  • Multiple Sclerosis (MS)
  • Interleukin-6
  • Interleukin-17
  • Developed Physical Disability Status
  • Physical Exercise

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دانشور پزشکی
دوره 31، شماره 3 - شماره پیاپی 166
مرداد و شهریور 1402
صفحه 81-94

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