عنوان مقاله [English]
Background and Objective: Obesity by expansion of adipose tissue and changing its secretory profile has undesirable effects on the other body tissues. However, different types of exercise training because of their role for improving lipid metabolism, considered as an effective strategy to combat obesity. Accordingly, changes in the plasma levels of WISP-1, ICAM-1, and VCAM-1 after 12 weeks high intensity interval training (HIIT) and moderate intensity continuous training (MICT) in women with type 2 diabetes were investigated in the present study.
Materials and Methods: In this study, 36 type-2 diabetic women with an age of 46.95±3.49 years participated in this study, which randomly assigned into three groups including HIIT, MICT and control groups. The exercise training program conducted as HIIT (90% maximum heart rate) and MICT (60-70% maximum heart rate) for 12 weeks and three sessions per week. For measurement of variables, blood sampling conducted before and after (48 hours after the last training session) 12 weeks of exercise training in fasting state. For data analysis, analysis of covariance test along with Bonferroni's post hoc test were used.
Results: According to present findings, WISP-1 levels reduction was significant in HIIT (p<0.001) and MICT (p=0.007) groups. ICAM-1 levels also showed a significant decrease in HIIT (p<0.001) and MICT (p<0.001) groups. However, the reduction of VCAM-1 levels was significant only in the HIIT group (p=0.031). These changes were associated with a significant decrease in insulin resistance in HIIT and MICT groups (p<0.001).
Conclusion: The present findings showed the positive effects of exercise training (HIIT and MICT) for decreasing inflammatory and cardiovascular risk factors. Because of greater effects observed for HIIT, participating in this type of training program could be very important for obese people.