تغییرات سطوح پروتئین-1 مسیر سیگنالی القایی WNT (WISP-1)، ICAM-1 و VCAM-1 در زنان دیابتی نوع 2 متعاقب 12 هفته تمرین تناوبی شدید و تمرین تداومی با شدت متوسط

نوع مقاله : مقاله پژوهشی

نویسنده

گروه تربیت بدنی و علوم ورزشی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران.

چکیده

مقدمه و هدف: چاقی به‌واسطه گسترش بافت چربی و تغییرات در نیم‌رخ ترشحی این بافت می‌تواند عملکردهای زیان‌باری بر سایر بافت‌های بدن داشته باشد. بااین‌همه، انواع مختلف تمرین ورزشی به‌واسطه نقشی که در بهبود متابولیسم لیپید دارند، یک استراتژی مؤثر برای مقابله با چاقی هستند. بر همین اساس، در این مطالعه به بررسی تغییرات در سطوح پلاسمایی WISP-1، ICAM-1 و VCAM-1 در زنان مبتلا به دیابت نوع 2 بعد از 12 هفته تمرین تناوبی شدید (HIIT) و تمرین تداومی با شدت متوسط (MICT) پرداخته شده است.
مواد و روش ها: تعداد 36 زن با میانگین سنی 49/3±95/46 سال مبتلا به دیابت نوع 2 در این مطالعه شرکت داشتند که به‌صورت تصادفی در سه گروه HIIT، MICT و کنترل قرار گرفتند. برنامه تمرین ورزشی به‌صورت HIIT (90درصد ضربان قلب بیشینه) و MICT (70-60درصد ضربان قلب بیشینه) طی 12 هفته و سه جلسه در هفته اجرا شد. به‌منظور اندازه‌گیری سطوح متغیرها، خون‌گیری قبل و بعد (48 ساعت بعد از جلسه آخر تمرین) از 12 هفته تمرین ورزشی در حالت ناشتایی انجام شد. به‌منظور تجزیه و تحلیل داده‌ها نیز از آزمون آنالیز کوواریانس به همراه آزمون تعقیبی بونفرونی استفاده شد.
نتایج: مطابق یافته‌های حاضر، کاهش سطوح WISP-1 در گروه‌های HIIT) (001/0>p) و MICT (007/0=p)معنادار بود. سطوح ICAM-1 نیز کاهش معناداری را در گروه‌های HIIT (001/0>p) وMICT  (001/0>p) نشان داد. باوجوداین، کاهش سطوح VCAM-1 تنها در گروه HIIT معنادار بود (031/0=p). این تغییرات با کاهش معنادار میزان مقاومت به انسولین در گروه‌های HIIT و MICT همراه بود (001/0>p).
نتیجه‌گیری: نتایج حاضر تأثیرات مثبت تمرینات ورزشی به‌صورت HIIT و MICT را در کاهش عوامل التهابی و خطرزای قلبی-عروقی نشان داد که با توجه به تأثیرات بیشتر مشاهده‌شده برای HIIT، شرکت در این تمرینات می‌تواند برای افراد چاق اهمیت فراوانی داشته باشد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Changes of WNT1-inducible signaling pathway protein-1 (WISP-1), ICAM-1 and VCAM-1 in type 2 diabetic women following 12-week high intensity interval training and moderate intensity continuous training

نویسنده [English]

  • Mandana Gholami
Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
چکیده [English]

Background and Objective: Obesity by expansion of adipose tissue and changing its secretory profile has undesirable effects on the other body tissues. However, different types of exercise training because of their role for improving lipid metabolism, considered as an effective strategy to combat obesity. Accordingly, changes in the plasma levels of WISP-1, ICAM-1, and VCAM-1 after 12 weeks high intensity interval training (HIIT) and moderate intensity continuous training (MICT) in women with type 2 diabetes were investigated in the present study.
Materials and Methods: In this study, 36 type-2 diabetic women with an age of 46.95±3.49 years participated in this study, which randomly assigned into three groups including HIIT, MICT and control groups. The exercise training program conducted as HIIT (90% maximum heart rate) and MICT (60-70% maximum heart rate) for 12 weeks and three sessions per week. For measurement of variables, blood sampling conducted before and after (48 hours after the last training session) 12 weeks of exercise training in fasting state. For data analysis, analysis of covariance test along with Bonferroni's post hoc test were used.
Results: According to present findings, WISP-1 levels reduction was significant in HIIT (p<0.001) and MICT (p=0.007) groups. ICAM-1 levels also showed a significant decrease in HIIT (p<0.001) and MICT (p<0.001) groups. However, the reduction of VCAM-1 levels was significant only in the HIIT group (p=0.031). These changes were associated with a significant decrease in insulin resistance in HIIT and MICT groups (p<0.001).
Conclusion: The present findings showed the positive effects of exercise training (HIIT and MICT) for decreasing inflammatory and cardiovascular risk factors. Because of greater effects observed for HIIT, participating in this type of training program could be very important for obese people.

کلیدواژه‌ها [English]

  • High Intensity Interval Training
  • Moderate Intensity Continuous Training
  • WNT1-inducible signaling pathway protein-1
  • Intercellular Adhesion Molecule 1
  • Vascular Cell Adhesion Molecule 1

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دانشور پزشکی
دوره 31، شماره 3 - شماره پیاپی 166
مرداد و شهریور 1402
صفحه 68-80

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