پاسخ سطوح پلاسمایی آیریزین، فولیستاتین و FGF21 به تمرینات هوازی در زنان بهبودیافته از کووید-19

نوع مقاله : مقاله پژوهشی

نویسندگان

1 گروه تربیت بدنی و علوم ورزشی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران

2 گروه بیماری‌های عفونی، دانشگاه علوم پزشکی، آبادان، ایران

3 گروه فیزیولوژی، دانشگاه علوم پزشکی، آبادان، ایران

چکیده

مقدمه و هدف: به‌تازگی انجام فعالیت‌های ورزشی منظم به‌واسطه ترشح مایوکاین‌ها به‌عنوان راهکاری مناسب جهت بازتوانی، کنترل عوارض و پیامدهای مرتبط با کووید-19 مورد توجه قرار گرفته است. هدف از انجام این مطالعه بررسی پاسخ سطوح پلاسمایی آیریزین، فولیستاتین و فاکتور رشد فیبروبلاست 21 (FGF21) به تمرینات هوازی در زنان بهبودیافته از کووید-19 بود.
مواد و روش ها: 22 زن بهبودیافته از کووید-19 شهرستان‌های آبادان و خرمشهر پس از فراخوان عمومی و گزینش در دو گروه 11 نفره شامل گروه تمرین هوازی و گروه کنترل تقسیم‌بندی شدند. گروه تمرینات هوازی پروتکل تمرینی را با شدت 50 تا 70 درصد ضربان قلب ذخیره و به مدت هشت هفته (سه جلسه در هفته) اجرا کردند. قبل و پس از پایان پروتکل تمرینی نمونه‌های خونی جمع‌آوری شد و اندازه‌گیری سطوح آیریزین، فولیستاتین و FGF21 به روش الایزا انجام شد. داده‌ها با استفاده از آزمون آماری کوواریانس (آنکوا) در سطح (05/0>P) آنالیز شد.
نتایج: بر اساس مقایسه بین‌گروهی داده‌ها، مقادیر آیریزین (05/0>P)، فولیستاتین (05/0>P) و FGF21 و(05/0>P) گروه هوازی در مقایسه با گروه کنترل افزایش معناداری داشته است. همچنین تغییرات درون‌گروهی آیریزین (05/0>P)، فولیستاتین (05/0>P) و FGF21) (05/0>P) نیز نشان داد که بین میانگین قبل و بعد گروه هوازی افزایش معنادار وجود دارد.
نتیجه‌گیری: انجام تمرینات هوازی در زنان بهبودیافته از کووید-19 می‌تواند در بازیابی پروفایل مایوکاینی آنها مؤثر باشد.

کلیدواژه‌ها

عنوان مقاله [English]

Response of plasma levels of Irisin, Follistatin and FGF21 to aerobic exercise in women recovered from Covid-19

نویسندگان [English]

  • Parisa Amiri farsani 1
  • Farshad Ghazalian 1
  • Sara Mobarak 2
  • Esmat Radmanesh 3
  • Mandana Gholami 1
1 Department of Physical Education and Sports Sciences, Science and Research Unit, Islamic Azad University, Tehran, Iran
2 Department of Infectious Diseases, University of Medical Sciences, Abadan, Iran
3 Department of Physiology, University of Medical Sciences, Abadan, Iran
چکیده [English]

Background and Objective: Recently, performing regular sports activities due to the release of Myokines has been considered as a suitable strategy for rehabilitation, control of complications and consequences related to Covid-19. The purpose of this study was to investigate the response of plasma levels of Irisin, Follistatin and FGF21 to aerobic training in women recovered from Covid-19.
Materials and Methods: 22 women recovered from Covid-19 in Abadan and Khorramshahr cities were divided into two groups of 11 people, including the aerobic exercise group and the control group, after a general call and selection. The aerobic exercise group performed the exercise protocol with an intensity of 50 to 70% of the reserve heart rate for eight weeks (three sessions per week). Before and after the end of the training protocol, blood samples were collected and Irisin, Follistatin and FGF21 levels were measured by ELISA method. The data were analyzed using the statistical test of covariance (ANCOA) at p<0.05.
Results: Based on the comparison of data between the groups, values of Irisin (P<0.05), Follistatin (P<0.05) and FGF21 (P<0.05) in the aerobic group significantly increased as compared to the control group. Also, intragroup changes of Irisin (P<0.05), Follistatin (P<0.05) and FGF21 (P<0.05) also showed that there is a significant increase between the average before and after the aerobic group.
Conclusion: Performing aerobic exercises in women recovered from Covid-19 can be effective in restoring their Myokine profile

کلیدواژه‌ها [English]

  • Covid-19
  • Irisin
  • Follistatin
  • FGF21

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دانشور پزشکی
دوره 31، شماره 3 - شماره پیاپی 166
مرداد و شهریور 1402
صفحه 55-67

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