تأثیر 10 هفته تمرینات استقامتی در آب بر سالخوردگی سیستم ایمنی رت‌های سالمند

نوع مقاله : مقاله پژوهشی

نویسندگان

1 گروه فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه حکیم سبزواری؛ سبزوار، ایران

2 گروه زیست‌شناسی، دانشکده علوم پایه، دانشگاه حکیم سبزواری؛ سبزوار، ایران

چکیده

مقدمه و هدف: مجموعه‌ای از لنفوسیت‌های بکر محدودشده همراه با تجمع سلول‌های T سالخورده و انحلال تیموس از عوامل اصلی ایجادکننده سالخوردگی سیستم ایمنی هستند که با تمرین ورزشی می‌توان این عوامل را تعدیل کرد؛ بنابراین هدف از پژوهش حاضر بررسی 10 هفته تمرین استقامتی در آب بر سالخوردگی سیستم ایمنی در رت‌های سالمند است.
مواد و روش ها: 16 رت 24 ماهه به‌صورت تصادفی به دو گروه تمرین استقامتی (8n=) و کنترل (8n=) تقسیم شدند. تمرینات استقامتی 4 جلسه در هفته در ظرفی به ابعاد 50*50*100 با آب 1±30 درجه سانتی‌گراد اجرا شد. داده‌ها توسط آزمون تی مستقل با نرم‌افزار SPSS ورژن 22 در سطح (05/0P<) آنالیز شدند.
نتایج: تفاوت معناداری بین دو گروه تمرین و کنترل در سلول‌های +TCD4 و TCD8+، لنفوسیت‌های بکرCD8+ ، CD8+ سالخورده، CD8+ بکر سالخورده وجود داشت (01/0P=)، درحالی‌که در دو شاخص وزن تیموس (43/0P=) و نسبت CD4+/CD8+ تفاوت معناداری مشاهده نشد (29/0P=).
نتیجه‌گیری: درنهایت، نتایج این مطالعه نشان می‌دهد که تمرینات استقامتی در آب یک فعالیت ایمن برای سالمندان به‌منظور بهبود سیستم ایمنی و کاهش سالخوردگی سلول‌های T است.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The effect of 10-week endurance training in water on immunosenescence in elderly rats

نویسندگان [English]

  • Mohammad Jahanmahin 1
  • Roya Askari 1
  • Amirhossein Haghighi 1
  • Toktam Hajjar 2
1 Faculty of Physical Education & Sport Sciences, Department of Exercise Physiology, Sabzevar, Iran
2 Department of Basic Sciences, Faculty of Biology, Sabzevar, Iran
چکیده [English]

Background and Objective: A complex of restricted naïve lymphocytes in conjunction with an age-associated accumulation of senescent T cells and/or thymic involution are major contributors to the immunosenescence, which can be modulated by exercise training. Therefore, the aim of the present study was to investigate the effect of 10-week endurance training in water on immunosenescence in elderly rats.
Materials and Methods: 16 rats (24 months old) were randomly distributed into control group (n=8) and endurance training (n=8). Endurance training was performed in 4 sessions per week in a container with dimensions of 50x50x100 with water at 30±1ºC. Data were analyzed by independent sample T test with SPSS software version 22 at significance level <0.05.
Results: There was a significant difference between the two training and control groups in CD4+ and CD8+ T cells, naïve TCD8+ and lymphocytes, senescent TCD8+, senescent naïve TCD8+ (P=0.01), while significant difference was not observed between thymus weight (P=0.43) and CD4+/CD8+ T cell ratio (P=0.29).
Conclusion: The results of this study suggest that endurance training in water is a safe activity for elderly in order to improve the immune system and reduction of senescence-prone T cells.

کلیدواژه‌ها [English]

  • Immunosenescence
  • T lymphocytes
  • Endurance training
  • TCD4+
  • TCD8+

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دانشور پزشکی
دوره 31، شماره 3 - شماره پیاپی 166
مرداد و شهریور 1402
صفحه 22-33

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