آثار تمرین موازی و محدودیت کالری بر آدیپوکاین‌‌های ضدالتهابی و حساسیت انسولینی در زنان چاق مبتلا به کبد چرب

نوع مقاله : مقاله پژوهشی

نویسندگان

گروه فیزیولوژی ورزش، دانشکده علوم انسانی، دانشگاه آزاد اسلامی واحد ایلام، ایلام، ایران

چکیده

مقدمه و هدف: اختلال در تنظیم ترشح بین آدیپوکاین‌های التهابی و ضدالتهابی می‌تواند منجر به مقاومت به انسولین و دیابت نوع دو شود. هدف پژوهش حاضر بررسی آثار تمرین موازی، محدودیت کالری و تمرین موازی+ محدودیت کالری بر سطوح آدیپوکاین‌های ضدالتهابی و حساسیت به انسولین در زنان چاق مبتلا به کبد چرب غیرالکلی بود.
مواد و روش ها: در این مطالعه، 37 زن بیمار مبتلا به کبد چرب به‌صورت تصادفی در چهار گروه کنترل (9=n)، محدودیت کالری (9=n)، تمرین موازی (9=n) و تمرین موازی+ محدودیت کالری (10=n) تقسیم شدند. تمرین موازی به‌صورت ترکیبی از تمرین هوازی با شدت 40 تا 60 درصد ضربان ذخیره و تمرین مقاومتی با شدت 40 تا 60 درصد یک تکرار بیشینه، سه جلسه در هفته و به مدت 8 هفته اجرا شد. در گروه‌های محدودیت کالری، میزان کل کالری دریافتی روزانه ۴۰۰-۵۰۰ کیلو کالری طی 8 هفته کاهش یافت. نمونه‌های خونی ناشتا پیش و پس از مداخله اخذ شد. داده‌ها با استفاده از آزمون‌های t زوجی و تحلیل کوواریانس در سطح معناداری 05/0>p تجزیه و تحلیل شدند.
نتایج: تمرین موازی+ محدودیت کالری غلظت آدیپونکتین و آدیپولین سرمی را در مقایسه با گروه‌های محدودیت کالری و کنترل (هر دو، 026/0>p) و شاخص حساسیت انسولینی را نسبت به گروه کنترل به‌طور معناداری افزایش داد (027/0=p). همچنین، در غلظت آدیپونکتین و آدیپولین سرمی و شاخص حساسیت انسولینی گروه تمرین موازی نسبت به گروه کنترل افزایش معنادار دیده شد (همه، 038/0>p). در گروه محدودیت کالری تنها شاخص حساسیت انسولینی نسبت به پیش‌آزمون افزایش معناداری داشت (004/0=p).
نتیجه‌گیری: به نظر می‌رسد اجرای تمرین موازی به تنهایی و همراه با محدودیت کالری مداخله مؤثرتری در افزایش آدیپوکاین‌های ضدالتهابی و بهبود حساسیت انسولینی نسبت به صرفاً محدودیت کالری است.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The effects of concurrent training and calorie restriction on anti-inflammatory adipokines and insulin sensitivity in obese women with fatty liver

نویسندگان [English]

  • Elahe Saiedinejad
  • Abdolhossein Taheri Kalani
  • Fardin Fatahi
Department of Exercise Physiology, Faculty of Humanities, Ilam Branch, Islamic Azad University, Ilam, Iran
چکیده [English]

Background and Objective: Disturbance in the regulation of secretion between inflammatory and anti-inflammatory adipokines can lead to insulin resistance and type 2 diabetes. The aim of the present study was to investigate the effects of concurrent training, calorie restriction and concurrent training+ calorie restriction on the levels of anti-inflammatory adipokines and insulin sensitivity in obese women with non-alcoholic fatty liver disease.
Materials and Methods: Thirty seven women with non-alcoholic fatty liver were randomly divided into four groups: control (n=9), calorie restriction (n=9), concurrent training (n=9) and concurrent training+ calorie restriction (n=10). Training protocol included combination of aerobic with 40-60 percent of heart rate reserve and resistance training 40-60 percent of 1 repetition maximum (1RM), eight weeks and three sessions per week. The calorie restriction groups, alleviate 400 to 500 kcal/day from total daily calorie intake. Blood samples were taken pre- and post intervention. For statistical analysis, paired samples t-test and analysis of covariance at a significant level of p<0.05 were used.
Results: Concurrent training+ calorie restriction significantly increased serum adiponectin and adipolin concentration compared to the caloric restriction and control groups (both, p<0.026) and the insulin sensitivity index compared to the control group (p=0.027). Also, there was a significant increase in serum adiponectin and adipolin concentration and insulin sensitivity index of the concurrent training group compared to the control group (p<0.05). In the calorie restriction group, only the insulin sensitivity index increased significantly compared to the pre-test (p=0.004).
Conclusion: It seems that performing concurrent training alone and with calorie restriction is a more effective intervention in increasing anti-inflammatory adipokines and improving insulin sensitivity than calorie restriction alone.

کلیدواژه‌ها [English]

  • Concurrent training
  • Calorie restriction
  • Insulin sensitivity
  • Adiponectin
  • Adipolin

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دانشور پزشکی
دوره 31، شماره 2 - شماره پیاپی 165
خرداد و تیر 1402
صفحه 56-67

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