تأثیر هشت هفته تمرینات تناوبی با شدت بالا (HIIT) بر سطوح mir-27a سرمی و غلظت پروتئین واکنش گر -C در مردان چاق میانسال

نوع مقاله : مقاله پژوهشی

نویسندگان

1 گروه تربیت بدنی و علوم ورزشی، دانشگاه فنی و حرفه ای، تهران، ایران

2 گروه فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه تبریز، ایران

چکیده

مقدمه و هدف: چاقی به عنوان یک عامل خطر برای بسیاری از بیماری ها از جمله بیماری های سوخت و سازی و قلبی-عروقی شناخته می شود. از آنجایی که تأثیر تمرینات ورزشی روی میکرو RNAهای (miRNA) مرتبط با چاقی بویژه mir-27a به ندرت بررسی شده است؛  لذا، تحقیق حاضر با هدف بررسی تأثیر هشت تمرینات تناوبی با شدت بالا (HIIT) بر سطوح          mir-27a و غلظت پروتئین واکنشگر C (CRP) در مردان چاق انجام شد.
مواد و روش ها: 24 داوطلب مرد میانسال چاق (30 BMI>و دامنه سنی 40-50 سال) بصورت تصادفی به دو گروه تمرین و کنترل تقسیم شدند. گروه تمرینی هشت هفته تمرینات HIIT را بصورت دایره‌ای (زانو بلند، پروانه، بورپی، کتل بل اسنچ و اسکات گابلت)، با شدت 80-90% ضربان قلب کاروونن اجرا کردند (چهار هفته اول: سه جلسه و چهار هفته دوم: چهار جلسه در هفته). نمونه‌های خونی 48 ساعت قبل و 48 ساعت بعد از آخرین جلسه تمرینی به منظور تحلیل شاخص‌های mir-27a و CRP از آزمودنی‌ها دریافت شد. سپس، داده ها با استفاده از آزمون‌های تی مستقل و تی همبسته تجزیه و تحلیل شد.
نتایج: هشت هفته تمرین HIIT در مقایسه با گروه کنترل باعث کاهش معنی‌دار سطوح  mir-27a  وCRP شد (05/0>P).
نتیجه‌گیری: به نظر می‌رسد تمرینات ورزشی به ویژه تمرینات HIIT می تواند سبب کاهش mir-27 و CRP شده و احتمالاً با جلوگیری از التهاب ناشی از چاقی، از بروز بیماری های متابولیسمی جلوگیری نماید.

کلیدواژه‌ها

عنوان مقاله [English]

The effect of eight weeks of high-intensity interval training (HIIT) on mir-27a levels and serum c-reactive protein (CRP) concentration in middle-aged obese men

نویسندگان [English]

  • Hamidreza Zolfi 1
  • Amir Shakib 2
  • Adel Valipour 2
1 Department of Physical Education and Sport Science, Technical and Vocational University (TVU), Tehran, Iran
2 Faculty of Physical Education and Sport Sciences, University of Tabriz, Tabriz, Iran
چکیده [English]

Background and Objective: Obesity is known as a hazardous factor for many diseases including cardiovascular ones. Since the effect of exercise training on microRNAs (miRNA) related to obesity, especially mir-27a, has rarely been investigated; Therefore, the current research was conducted with the aim of investigating the effect of eight high-intensity interval training (HIIT) on mir-27a levels and C-reactive protein (CRP) concentration in obese men.
Materials and Methods: A total of 24 middle-aged obese men (BMI>30 and 44.07±4 years) volunteered were randomly divided into training (n=12) and control (n=12) groups. The training group performed eight weeks of HIIT in a circuit training (High Knee Jog, Jumping jack, burpee, kettlebell snatch, and goblet squat) at an intensity of 80-90% of the Karvonen heart rate (first four weeks: three sessions per week, second four weeks: four sessions per week). Mir-27a and CRP indices were measured in blood samples taken from subjects 48 hours before and after the last training session. Then, the data were analyzed by using independent and paired t-tests.
Results: Eight weeks of HIIT training significantly reduced mir-27a and CRP levels as compared to the control group (P <0.05).
Conclusion: Doing exercise, especially HIIT training one, can apparently reduce mir-27 and CRP and possibly prevent the metabolic diseases by counteracting inflammation caused by obesity.

کلیدواژه‌ها [English]

  • High-intensity interval training (HIIT)
  • mir-27a
  • C-reactive protein (CRP)
  • Obesity

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دانشور پزشکی
دوره 30، شماره 4 - شماره پیاپی 161
مهر و آبان 1401
صفحه 36-47

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