تغییر در سطح سرمی ANGPTL3، ANGPTL4 و CRP بعد از تمرینات ترکیبی به تنهایی و همراه با مصرف آویشن در مردان چاق

نوع مقاله : مقاله پژوهشی

نویسندگان

1 گروه تربیت بدنی و علوم ورزشی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران

2 گروه فیزیولوژی ورزشی، واحد تهران مرکزی، دانشگاه آزاد اسلامی، تهران، ایران

چکیده

مقدمه و هدف: مکمل آویشن نقش مهمی در مقابله با اختلالات ناشی از چاقی دارد و می‌تواند تاثیرات مثبت تمرین ورزشی در افراد چاق را تقویت کند. بنابراین، محقق در مطالعه حاضر تغییر در سطح سرمی پروتئین شبه آنژیوپویتین3  (ANGPTL3) و 4 (ANGPTL4) و پروتئین واکنشگر C (CRP) بعد از تمرینات ترکیبی به تنهایی و همراه با مصرف آویشن در مردان چاق را مورد بررسی قرار داده است.
مواد و روش ها: 40 مرد دارای اضافه وزن و چاق در گروه­های برابر 10 نفری مشتمل بر گروه­های دارونما (C)، آویشن (Z)، تمرین ترکیبی (CT) و تمرین ترکیبی+آویشن (CT+Z) در مطالعه حاضر شرکت کردند. هر جلسه تمرین ترکیبی مشتمل بر فعالیت ورزشی مقاومتی و استقامتی بود و مصرف روزانه مکمل آویشن نیز 500 میلی­گرم بود. نمونه­های خونی قبل و بعد از اتمام هشت هفته مداخله جمع­آوری شد و سطوح سرمی ANGPTL3، ANGPTL4 و CRP به روش الایزا اندازه­گیری شد. از آزمون تحلیل کوواریانس و آزمون تعقیبی بونفرونی برای تجزیه و تحلیل یافته­ها استفاده شد.
نتایج: سطوح سرمی ANGPTL3 در گروه­های CT و CT+Z نسبت به گروه­های C و Z به صورت معناداری کاهش یافت (001/0>p). باوجود این، تغییرات سطوح سرمی ANGPTL4 در گروه­های مختلف پژوهشی از نظر آماری معنادار نبود (059/0=p). همچنین، کاهش معنادار سطوح سرمی CRP در گروه­های CT (015/0=p) و CT+Z (003/0=p) در مقایسه با گروه C مشاهده شد.
نتیجه‌گیری: به نظر می‌رسد که تاثیرات مثبت تمرین ترکیبی به تنهایی و همراه با مصرف آویشن در مردان چاق تاحدودی بواسطه کاهش معنادار آدیپوکاین‌های التهابی (ANGPTL3، CRP) اعمال می‌شود، اگرچه مصرف آویشن به همراه تمرین ترکیبی تاثیر سینرژیک نداشته است.

کلیدواژه‌ها

عنوان مقاله [English]

Changes in the serum levels of ANGPTL3, ANGPTL4 and CRP following combined training alone or in combination with thyme ingestion in the obese men

نویسندگان [English]

  • Arash Sadeghi 1
  • Mandana Gholami 1
  • Hasan Matinhomaee 2
  • Hosein Aabednatanzi 1
  • Farshad Ghazalian 1
1 Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
2 Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
چکیده [English]

Background and Objective: Thyme supplement plays an important role in combating obesity related disorders and can enhance the positive effects of exercise training in obese individuals. Therefore, researcher in the present study investigated the changes in the serum levels of angiopoietin-like protein 3 (ANGPTL3) and 4 (ANGPTL4), and C-reactive protein (CRP) following combined training alone or in combination with thyme ingestion in the obese men.
Materials and Methods: The 40 overweight and obese men in the equal 10 person groups including placebo (C), thyme (Z), training (CT) and training+thyme (CT+Z) groups participated in the present study. Each combined training session consist of resistance and endurance exercise, and thyme supplement was also consumed at 500 mg daily. Blood samples collected before and after eight weeks intervention and serum levels of ANGPTL3, ANGPTL4, and CRP was measured by ELISA method. Data were analyzed by means of analysis of covariance test and bonferroni post hoc test.
Results: Serum levels of ANGPTL3 in the CT and CT+Z groups decreased significantly compared to C and Z groups (p<0.001). However, there was no significant difference between different groups for serum ANGPTL4 levels (p=0.059). In addition, significant decrease in serum levels of CRP in the CT (p=0.015) and CT+Z (p=0.003) groups compared to C group were observed.
Conclusion: It seems that, positive effects of combined training alone or in combination with thyme consumption in the obese men is partly due to a significant decrease in inflammatory adipokines (ANGPTL3, CRP), although consumption of thyme with combined training has no synergistic effect.

کلیدواژه‌ها [English]

  • Combined training
  • Thyme
  • Angiopoietin-like protein
  • Inflammation

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دانشور پزشکی
دوره 30، شماره 2 - شماره پیاپی 159
خرداد و تیر 1401
صفحه 61-73

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