دانشور پزشکی

دانشور پزشکی

تأثیر تمرین تناوبی سرعتی بر آنزیم‌های کبدی، ظرفیت آنتی‌اکسیدانی تام و مالون دی آلدئید بافت کبدی موش بزرگ آزمایشگاهی نر

نوع مقاله : مقاله پژوهشی

نویسندگان
محمدحسن احمدی 1
محمد رحمانی 1
محسن خلیلی نجف آبادی 2
1 گروه تربیت بدنی و علوم ورزشی، دانشکده علوم انسانی، دانشگاه شاهد، تهران، ایران
2 مرکز تحقیقات نوروفیزیولوژی، دانشگاه شاهد، تهران، ایران
10.22070/daneshmed.2022.15639.1164
چکیده
مقدمه و هدف: هدف از مطالعه حاضر بررسی تأثیر تمرین تناوبی سرعتی (SIT) بر میزان آنزیم‌های کبدی، ظرفیت آنتی اکسیدانی تام (TAC) و ماالوان-دی-آلدهید (MDA) بافت کبدی بود.
مواد و روش ها: در یک کارآزمایی تجربی، 16 سر موش بزرگ آزمایشگاهی نر (موش) تصادفی به دو گروه کنترل (8=CO, n) و تمرین(8= EX, n) تقسیم شدند. موش‌ها پس از دوران سازگاری با محیط و آشنایی با تمرین، 8 هفته، هفته‌ای 3 جلسه تحت تمرین قرار گرفتند. در پایان دوره، پس از بیهوشی و خونگیری مستقیم از قلب، سرم برای سنجش‌های آنزیم‌های کبدی استخراج و بافت کبد جهت بررسی میزان TAC و MDA بافتی برداشته شد. برای تحلیل داده‌ها از آزمون آماری t مستقل در سطح آلفای 05/0 در محیط SPSS نسخه 22 استفاده شد.
نتایج: تحلیل آماری داده­ها حاکی از بالاتر بودن معنی­دار میزان TAC بافت کبد گروه EX نسبت به گروه CO  بود (01/0=P)؛ اما تفاوت  معنی­دار بین­گروهی در رابطه با  میزان MDA بافتی کبد مشاهده نشد (24/0=P). در رابطه با میزان آنزیم­های کبدی ALT (26/0=P) و GGT (44/0=P) نیز تفاوت بین­گروهی معنی­داری مشاهده نشد؛ اما میزان آنزیم  AST (01/0=P) و (001/0=P) ALP گروه EX نسبت به گروه CO به طور معنی­داری کمتر بود.
نتیجه‌گیری: نتایج نشان داد، تمرین SIT باعث افزایش ظرفیت آنتی اکسیدانی و تغییرات مطلوب در میزان آنزیم‌های کبدی می‌شود و این نوع پروتکل تمرینی می‌تواند پیامد مفیدی بر وضعیت سلامتی وعملکردی کبد داشته باشد.
کلیدواژه‌ها
پراکسیداسیون لیپیدی
ظرفیت آنتی اکسیدانی تام
تمرین SIT
آنزیم‌های کبدی
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دانشور پزشکی
دوره 30، شماره 2 - شماره پیاپی 159
خرداد و تیر 1401
صفحه 50-60