اثر فعالیت ورزشی هوازی و مکمل اسپیرولینا بر پپتیدهای مشتق از میتوکندری در مردان مسن دارای اضافه وزن

نوع مقاله : مقاله پژوهشی

نویسندگان

گروه فیزیولوژی ورزشی، واحد آیت الله آملی، دانشگاه آزاد اسلامی، آمل، ایران

چکیده

مقدمه و هدف: پپتیدهای مشتق از میتوکندری (MDPs) هیومنین (HN) و MOTS-c در بقای سلولی، سرکوب آپوپتوز و متابولیسم نقش دارند. هدف از این مطالعه بررسی تأثیر تمرین هوازی (AT) همراه با مکمل اسپیرولینا (SP) بر MDPs در مردان مسن دارای اضافه وزن بود.
مواد و روش ها: در این مطالعه کارآزمایی بالینی، 40 نفر مرد مسن دارای اضافه وزن شهر انزلی انتخاب (سن 84/4±50/57 سال، شاخص توده‌بدنی 85/2±90/26 کیلوگرم بر متر مربع) و به طور تصادفی به پنج گروه کنترل-سالم (CN)، اضافه‌وزن (Obe)، اضافه‌وزن-تمرین (ObeAT)، اضافه‌وزن-اسپیرولینا (ObeSP) و اضافه‌وزن-تمرین-اسپیرولینا (ObeATSP) تقسیم شدند. گروه‌های تمرین به مدت هشت هفته، هر هفته پنج جلسه در برنامه تمرینی هوازی (با شدت 65 تا 85 درصد حداکثر ضربان قلب، 40 دقیقه) شرکت کردند. به گروه‌های ObeSP و ObeATSP روزانه 2 عدد قرص 500 میلی‌گرمی SP در صبح و عصر داده شد. داده‌ها با استفاده از آزمون t همبسته و تحلیل کوواریانس در سطح معنی‌داری 05/0<p آزمون شد.
نتایج: نشان داده شده که AT و SP باعث افزایش HM (026/0P= و 046/0P=) و MOTS-c (005/0P= و 018/0P=) شد. همچنین مداخله همزمان AT و SP، اثر مثبت و تقویتی بر افزایش افزایش HM (0001/0P=) و MOTS-c (0001/0P=) داشت. نیمرخ چربی نیز به دنبال AT و مصرف SP بهبود یافت (05/0 p<).
نتیجه‌گیری: AT و SP با تاثیر بر سطوح سرمی HM و MOTS-c و همچنین نیمرخ چربی باعث بهبود عملکرد میتوکندری شده و وضعیت متابولیکی را در مردان دارای اضافه وزن بهبود می‌بخشد. با وجود این، اثر ترکیب تمرین و مکمل بیشتر بود.

کلیدواژه‌ها

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دانشور پزشکی
دوره 30، شماره 2 - شماره پیاپی 159
خرداد و تیر 1401
صفحه 12-23

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