مقایسه یک دوره تمرین هوازی با یک دوره مصرف مکمل ترکیبی گیاهی (سنبل الطیب هندی و بادرنجبویه) بر تغییرات سطوح سروتونین، نیتریک اکسید و شاخص‌های سردرد در زنان دارای میگرن

نویسندگان

گروه فیزیولوژی ورزشی، دانشکده تربیت‌بدنی و علوم ورزشی، دانشگاه گیلان، رشت، ایران

چکیده

مقدمه و هدف: میگرن یک اختلال عصبی- عروقی است که باعث کاهش کیفیت زندگی می‌شود. هدف از پژوهش حاضر بررسی تأثیر یک دوره تمرین هوازی و مکمل ترکیبی گیاهی شامل سنبل الطیب و بادرنجبویه بر سروتونین، نیتریک اکسید خون و شاخص‌های سردرد بود.
 
مواد و روش‌ها: در این مطالعه کاربردی، 18 بیمار زن مبتلا به میگرن که واجد شرایط شرکت در این مطالعه بودند، به صورت تصادفی در دو گروه تمرین هوازی (9 نفر) و مکمل ترکیبی گیاهی (9 نفر) قرار گرفتند. برنامه تمرین بیماران گروه تمرین هوازی در مدت هشت هفته و هر هفته سه جلسه و هر جلسه شامل 75 دقیقه فعالیت هوازی (15 دقیقه گرم کردن، 45 تمرین، 15 دقیقه سرد کردن) با شدت متوسط اجرا شد. گروه مکمل ترکیبی گیاهی نیز هشت هفته کپسول گیاهی مصرف کردند، هر کپسول شامل 200 میلی‌گرم سنبل الطیب و 80 میلی‌گرم بادرنجبویه بود که در چهار هفته اول دو بار در روز و در چهار هفته دوم سه بار در روز مصرف شد. نمونه‌های خونی در حالت ناشتا برای تعیین سطوح سروتونین و نیتریک اکسید خون آزمودنی‌ها، قبل و بعد از مرحله مداخله گرفته شد. همچنین شاخص‌های سردرد توسط پرسشنامه روزنگار سردرد ارزیابی شد. یافته‌ها با استفاده از آزمون‌های t مستقل، t همبسته و تحلیل کوواریانس مورد ارزیابی قرار گرفت (05/0P < /span>≤).
 
نتایج: نتایج آزمون نشان داد در گروه مکمل ترکیبی دو گیاه، مصرف هشت هفته کپسول باعث افزایش معنی‌داری در سطوح سروتونین خون و کاهش معنی‌دار در تعداد روزهای سردرد/تکرار سردرد و شدت سردرد گردید (05/0P≤). علاوه بر این، سطوح نیتریک اکسید خون و مدت سردرد نسبت به قبل از پژوهش تفاوتی نداشت (05/0P≥). در گروه تمرین هوازی، هشت هفته فعالیت باعث افزایش معنی‌داری در سطوح سروتونین و نیتریک اکسید خون و کاهش معنی‌داری در تعداد روزهای سردرد/تکرار سردرد و شدت سردرد گردید (05/0P≤)؛ اما مدت سردرد تغییری نکرد (05/0P≥). همچنین با مقایسه متغیرها بین دو گروه مشخص شد به غیر از نیتریک اکسید سرم و توان هوازی، تغییرات بقیه متغیرها در پایان مطالعه مشابه بود و تفاوت معنی‌داری بین آن‌ها مشاهده نشد.
 
نتیجه‌گیری: تمرین هوازی و مکمل ترکیبی شامل سنبل الطیب و بادرنجبویه می‌توانند مکمل درمانی مناسبی برای زنان مبتلا به میگرن باشد و تفاوتی بین آن‌ها وجود ندارد.

کلیدواژه‌ها


عنوان مقاله [English]

Comparison of an aerobic training course with a herbal supplementation (Valeriana wallichii and Melissa officinalis) regarding serotonin levels, nitric oxide and headache indices in women with migraine

نویسندگان [English]

  • Zohreh Eskandari
  • Bahman Mirzaei
  • Hamid Arazi
چکیده [English]

Background and Objective: Migraine is a neurovascular disorder that decreases the quality of life. The purpose of this study was to evaluate the effect of aerobic training and a combination of herbal supplements including Valeriana wallichii and Melissa officinalis on serotonin, nitric oxide and headache indices.
Materials and Methods: The present study was a semi-experimental and applied research. Eighteen female patients with migraine who were eligible to participate in the study were randomly divided into two groups: aerobic training (n=9) and herbal supplements (n=9). Patients in the aerobic exercise group performed the exercise for eight weeks, three sessions per week and each session was 75 minutes of moderate-intensity aerobic activity (15 minute warm-up, 45 workouts, 15 minute cool-down). The combination of herbal supplement group received herbal capsules for eight weeks and each capsule was included 200 mg of valerian and 80 mg of Melissa officinalis. They used it twice daily in the first four weeks and three times a day in the next four weeks. Blood samples were taken in the fasting state to determine the serotonin and nitric oxide levels of the subjects before and after the intervention. Headache indexes were also assessed by a headache questionnaire. Data were analyzed by Kolmogrov-Smirnov, independent and paired T-tests and Covariance analysis at a significance level of p<0.05.
Results: Results showed that in the complementary combination group, taking eight weeks of capsule significantly increased blood serotonin levels and headache frequency and intensity significantly decreased. In addition, nitric oxide levels and duration of headache did not significantly differ as compared to before the study. In the aerobic training group, eight weeks of activity significantly increased serotonin and nitric oxide levels and significantly decreased headache frequency and headache intensity, but did not change the duration of the headache. Also, by comparing the variables between the two groups, other than serum nitric oxide and aerobic power, the changes of the other variables were similar at the end of the study, and no significant difference was observed between them.
Conclusion: Aerobic training and a combination of herbal supplements including valerian and Melissa officinalis can be a good complement therapy for women with migraine.

کلیدواژه‌ها [English]

  • Migraine
  • Serotonin
  • Nitric oxide
  • Aerobic exercise
  • Valeriana wallichii
  • Melissa officinalis
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