اولویت‌بندی مفردات دارویی مؤثر بر زخم پای دیابتی در طب سنتی ایران

نویسندگان

1 گروه طب سنتی، دانشکده پزشکی، دانشگاه شاهد، تهران، ایران

2 دانشکده داروسازی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران

3 مرکز تحقیقات کار آزمایی بالینی طب سنتی، دانشگاه شاهد، تهران، ایران

چکیده

مقدمه و هدف: کشف دارو بر اساس داروهای سنتی فارماکولوژی معکوس نامیده می‌شود. هنگام جستجوی داروهای طب سنتی با دو دسته بیماری، مواجه هستیم: نخست، بیماری‌هایی مانند یبوست که امکان تطبیق نسبی یا کامل آن‌ها در طب رایج و طب سنتی وجود دارد. دوم، بیماری‌هایی مانند زخم پای دیابتی که به‌طور مستقیم، ذکری از آن‌ها در طب سنتی وجود ندارد. هدف از پژوهش حاضر، اولویت‌بندی مفردات طب سنتی و استفاده از فارماکولوژی معکوس، برای ساخت داروهای جدید مؤثر بر زخم پای دیابتی است.
 
مواد و روش‌ها: در این تحقیق کتابخانه‌ای، در سطح اول، انواع قروح در 4 منبع طب سنتی، جستجو و جمع‌آوری گردیدند و سپس بر اساس تشابه با علائم اصلی زخم پای دیابتی، قروح به دو گروه دارای علائم نزدیک به زخم پای دیابتی و دور از آن، تقسیم‌بندی شدند. در سطح بعد، مفردات مؤثر بر قروح بر اساس تأکید حکما و تکرار در منابع، امتیازبندی گردیدند. سرانجام، با جمع امتیاز دو سطح تقسیم‌بندی، مفردات مذکور را، رتبه‌بندی نمودیم.
 
نتایج: مورد، کندر، بارهنگ، صبر زرد و کاکنج، 5 مفرده نخست مؤثر بر زخم پای دیابتی می‌باشند. همچنین، میوه مورد جهت ساخت داروی زخم پای دیابتی پیشنهاد می‌گردد.
 
 نتیجه‌گیری: برای استفاده از دانش قدیم در درمان بیماری‌های امروزی، نخست باید بین دو طب نوین و قدیم، ارتباط منطقی برقرار شود، سپس اولویت‌بندی مفردات دارویی و استفاده از فارماکولوژی معکوس جهت ساخت داروهای جدید مؤثر بر زخم پای دیابتی انجام شود.

کلیدواژه‌ها


عنوان مقاله [English]

Prioritization of effective Materia Medica on diabetic foot ulcer in Persian medicine

نویسندگان [English]

  • Seyed-Ali Khodaie 1
  • Mohammad Kamalinejad 2
  • Fatemeh Emadi 1
  • Mohsen Naseri 3
چکیده [English]

Background and Objective: Drug discovery based on traditional medicines is called reverse pharmacology. During investigation of traditional medicine, there are two categories of diseases: The first, diseases such as constipation which they could be partially or fully matched in conventional and traditional medicine. The second, diseases such as diabetic foot ulcer (DFU) that, there is no direct mention about them in the context of traditional medicine. The aim of this study was to prioritize the materia medica utilized in Persian medicine for treatment of ghorooh (wounds) and using a reverse pharmacology approach to develop new effective drugs for DFU.
 
Materials and Methods: In this library study, on the first level, different types of ghorooh were searched and collected in four references of traditional medicine and then, these data were rated into two groups based on similarity with the main symptoms of DFU: Ghorooh with symptoms closed to DFU and ghorooh with symptoms away from DFU. In later levels, different materia affecting ghorooh were scored based on repetition in sources and scientists emphasis. Lastly, adding the scores of the two levels, acquired data was ranked in term of effect on DFUs.
 
Results: Myrtle, Frankincense, Plantain, Aloe Vera and Chinese lantern had highest scores. Finally, the myrtle fruits suggested for preparing the best formulation drug for DFU.
 
Conclusion: For use of traditional knowledge in modern diseases, first, we must establish a logical connection between conventional and traditional medicine. Then, prioritization of effective materia medica and reverse pharmacology could lead to production of new effective drugs for DFU.

کلیدواژه‌ها [English]

  • Persian medicine
  • Diabetic foot ulcer
  • Myrtle
  • Plantain
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