نویسندگان
1 مرکز تحقیقات کارآزمایی بالینی طب سنتی، دانشگاه شاهد
2 مرکز تحقیقات طب و داروسازی سنتی، دانشکده طب سنتی، دانشگاه علوم پزشکی تهران
3 مرکز تحقیقات طب سنتی، دانشکده طب سنتی، دانشگاه علوم پزشکی قم
4 گروه فارماکولوژی، دانشکده پزشکی، دانشگاه شاهد
چکیده
کلیدواژه‌ها
عنوان مقاله [English]
نویسندگان [English]
Background and
Objective:
HESA-A is a natural compound with
herbal-marine origin that
its therapeutic
effects have
been proved in
cancer.
The present study investigated HESA-A drug effect in an inflammatory model in
rats. Materials and
Methods:
In this study, four groups of rats were used with a sample size of six in each
group. These groups were negative control (distilled water), positive control
(methylprednisolone) and treatment groups (HESA-A at dosages of 150 and 225
mg/kg). On the first day, the drugs were injected intra-peritoneally to rats.
After thirty minutes, paw volume was measured by plethysmometer and
immediately, formalin solution was injected subcutaneously into the hind paw of
rats. After an hour, inflamed paw volume was measured. In days 2-8, the
inflamed paw volume was measured and immediately drug was injected
intra-peritoneally. Results: In this study,
comparing of the HESA-225 and control groups and also HESA-225 and HESA-150
groups, indicated significant differences in days 2-8. The mean volume of rats
paw in HESA-225 group was significantly less than HESA-150 and control groups
(p < 0.05). In addition, a significant decrease in the mean volume of rats’ paw was
observed in methylprednisolone group as compared to control group in days 3-8
(p < 0.05). Conclusion: The HESA-A drug has
a chronic anti-inflammatory effect following intraperitoneal administration.
کلیدواژه‌ها [English]
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