اثر محافظتی تمرین هوازی همراه با مصرف مریم گلی (Salvia officinalis) بر شاخص‌های عملکرد اندوتلیال در زنان یائسه

نوع مقاله : مقاله پژوهشی

نویسندگان

گروه فیزیولوژی ورزشی، واحد آیت الله آملی، دانشگاه آزاد اسلامی، آمل، ایران

چکیده

مقدمه و هدف: یائسگی با کاهش استروژن و اختلال در عملکرد اندوتلیال همراه بوده که به خطر آترواسکلروز کمک می‌کند. مولکول‌های چسبان نقش مهمی در ایجاد و پیشرفت آترواسکلروز عروق کرونر دارند. هدف از این مطالعه مقایسه اثر ورزش هوازی، مریم‌گلی و ترکیب آنها بر سطوح سرمی مولکول چسبندگی بین سلولی-1 (ICAM-1)، مولکول چسبندگی سلولی عروقی محلول 1 (sVCAM-1) و اندوتلین-1 (ET-1) در زنان یائسه بود.
مواد و روش ها: در این مطالعه کارآزمایی بالینی، 32 نفر زن یائسه انتخاب (سن 5/4 ± 62/51 سال، شاخص توده بدنی 89/2 ± 07/24 کیلوگرم بر متر مربع) و به‌طور تصادفی به چهار گروه کنترل-دارونما (C)، تمرین هوازی (AT)، مریم‌گلی (So) و تمرین- مریم‌گلی (ATSo) تقسیم شدند. گروه‌های تمرین به مدت هشت هفته، هر هفته پنج جلسه در برنامه تمرینی هوازی (با شدت 40 تا 80 درصد حداکثر ضربان قلب ذخیره، 25 تا 45 دقیقه) شرکت کردند. به گروه‌های So و ATSo روزانه 3 عدد قرص 100 میلی‌گرمی So در صبح، ظهر و عصر داده شد. داده‌ها با استفاده از آزمون t همبسته و تحلیل کوواریانس در سطح معنا‌داری 05/0> p آزمون شد.
نتایج: AT و So باعث کاهش معنا‌دار ICAM-1 (022/0= p و 041/0=P)، sVCAM-1 (015/0=P و 018/0=P) و ET-1 (016/0=P و 023/0=P) شد. همچنین مداخله هم‌زمان AT و SP، اثر مثبت بر کاهش ICAM-1 (0001/0=P)، sVCAM-1 (0001/0=P) و ET-1 (0001/0=P) داشت.
نتیجه‌گیری: AT و So با تأثیر بر سطوح سرمی ICAM-1، sVCAM-1 و ET-1 باعث بهبود عملکرد اندوتلیال در زنان یائسه می‌شود. باوجوداین، اثر ترکیب تمرین و مکمل بیشتر بود.

کلیدواژه‌ها

عنوان مقاله [English]

Protective effect of aerobic training with Salvia officinalis consumption on endothelial function indices in postmenopausal women

نویسندگان [English]

  • Niloo Alaie
  • Ahmad Abdi
Department of Physical Education and Sport Science, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.
چکیده [English]

Background and Objective: Menopause occurs with estrogens decline and impaired endothelial function and contributes to atherosclerotic risk. Adhesion molecules play an important role in the development and progression of coronary atherosclerosis. The aim of this study was comparing the effect of aerobic exercise, Salvia officinalis and their combination on serum levels of intercellular adhesion molecule (ICAM)-1, soluble vascular cellular adhesion molecule 1 (sVCAM-1) and endothelin-1 in postmenopausal women.
Materials and Methods: In this clinical trial study, 32 menopausal women (age 51.62±4.55 years, BMI 24.07±2.89 kg/square meters) were selected and were randomly divided into four groups including placebo control (C), aerobic training (AT), Salvia officinalis (So) and training-Salvia officinalis (ATSo). Training groups participated in an aerobic exercise program for eight weeks, five sessions per week (with an intensity of 40to 80% of maximum reserve heart rate, 25-45 minutes). The groups So and ATSo were provided three 100 mg So tablets daily in the morning, noon and evening. Data were tested using dependent t-test and analysis of covariance at a significance level of p<0.05.
Results: AT and So significantly decreased ICAM-1 (P=0.022 and P=0.041), sVCAM-1 (P=0.015 and P=0.018) and ET-1 (P=0.016 and P=0.023). Also, simultaneous intervention of AT and SP had a positive effect on reducing ICAM-1 (P=0.0001), sVCAM-1 (P=0.0001) and ET-1 (P=0.0001).
Conclusion: AT and So improve endothelial function in postmenopausal women by affecting serum levels of ICAM-1, sVCAM-1 and ET-1. Nevertheless, the effect of combination of exercise and supplementation was greater.

کلیدواژه‌ها [English]

  • Exercise
  • Salvia officinalis
  • ICAM-1
  • VCAM-1
  • ET-1
  • Menopause

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دانشور پزشکی
دوره 31، شماره 2 - شماره پیاپی 165
خرداد و تیر 1402
صفحه 46-55

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