اثر فعالیت ورزشی هوازی و مکمل اسپیرولینا بر پپتیدهای مشتق از میتوکندری در مردان مسن دارای اضافه وزن

نوع مقاله : مقاله پژوهشی

نویسندگان

گروه فیزیولوژی ورزشی، واحد آیت الله آملی، دانشگاه آزاد اسلامی، آمل، ایران

چکیده

مقدمه و هدف: پپتیدهای مشتق از میتوکندری (MDPs) هیومنین (HN) و MOTS-c در بقای سلولی، سرکوب آپوپتوز و متابولیسم نقش دارند. هدف از این مطالعه بررسی تأثیر تمرین هوازی (AT) همراه با مکمل اسپیرولینا (SP) بر MDPs در مردان مسن دارای اضافه وزن بود.
مواد و روش ها: در این مطالعه کارآزمایی بالینی، 40 نفر مرد مسن دارای اضافه وزن شهر انزلی انتخاب (سن 84/4±50/57 سال، شاخص توده‌بدنی 85/2±90/26 کیلوگرم بر متر مربع) و به طور تصادفی به پنج گروه کنترل-سالم (CN)، اضافه‌وزن (Obe)، اضافه‌وزن-تمرین (ObeAT)، اضافه‌وزن-اسپیرولینا (ObeSP) و اضافه‌وزن-تمرین-اسپیرولینا (ObeATSP) تقسیم شدند. گروه‌های تمرین به مدت هشت هفته، هر هفته پنج جلسه در برنامه تمرینی هوازی (با شدت 65 تا 85 درصد حداکثر ضربان قلب، 40 دقیقه) شرکت کردند. به گروه‌های ObeSP و ObeATSP روزانه 2 عدد قرص 500 میلی‌گرمی SP در صبح و عصر داده شد. داده‌ها با استفاده از آزمون t همبسته و تحلیل کوواریانس در سطح معنی‌داری 05/0<p آزمون شد.
نتایج: نشان داده شده که AT و SP باعث افزایش HM (026/0P= و 046/0P=) و MOTS-c (005/0P= و 018/0P=) شد. همچنین مداخله همزمان AT و SP، اثر مثبت و تقویتی بر افزایش افزایش HM (0001/0P=) و MOTS-c (0001/0P=) داشت. نیمرخ چربی نیز به دنبال AT و مصرف SP بهبود یافت (05/0 p<).
نتیجه‌گیری: AT و SP با تاثیر بر سطوح سرمی HM و MOTS-c و همچنین نیمرخ چربی باعث بهبود عملکرد میتوکندری شده و وضعیت متابولیکی را در مردان دارای اضافه وزن بهبود می‌بخشد. با وجود این، اثر ترکیب تمرین و مکمل بیشتر بود.

کلیدواژه‌ها

عنوان مقاله [English]

Effect of aerobic training and spirulina supplementation on mitochondrial-derived peptides in overweight elderly men

نویسندگان [English]

  • Ammar Raoufi Sangachin
  • Ahmad Abdi
  • Alireza Barari
Department of Physical Education and Sport Science, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran
چکیده [English]

Background and Objective: Mitochondrial-derived peptides (MDPs) humanin (HN) and MOTS-c are involved in cell survival, suppression of apoptosis, and metabolism. The aim of this study was to evaluate the effect of aerobic exercise (AT) with Spirulina supplementation (SP) on MDPs in overweight elderly men.
Materials and Methods: In this clinical trial study, 40 overweight elderly men (age 57.50±4.84 years, BMI 26.90±2.85 kg/square meters) were selected from Anzali and were randomly divided into five groups Control-Normal (CN), Overweight (Obe), Overweight-Aerobic Training (ObeAT), Overweight-Spirulina (ObeSP) and Overweight-Aerobic Training-Spirulina (ObeATSP). Training groups participated in an aerobic exercise program for eight weeks, five sessions per week (with an intensity of 65 to 85% of maximum heart rate, 40 minutes). The groups of ObeSP and ObeATSP were provided two 500 mg SP tablets daily in the morning and evening. Data were tested using dependent t-test and analysis of covariance at a significance level of p<0.05.
Results: It was shown that AT and SP increased HM (P=0.026 and P=0.046) and MOTS-c (P=0.005 and P=0.018). Simultaneous intervention of AT and SP also had a positive and strengthening effect on increasing HM (P=0.00001) and MOTS-c (P=0.0001). Fat profile also improved following AT and SP consumption (p<0.05).
Conclusion: AT and SP improve mitochondrial function by improving serum HM and MOTS-c levels as well as fat profile and improve metabolic status in overweight men. Nevertheless, the effect of the combination of exercise and supplementation was greater.

کلیدواژه‌ها [English]

  • Exercise
  • Spirulina
  • Humanin
  • MOTS-c
  • Overweight

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دانشور پزشکی
دوره 30، شماره 2 - شماره پیاپی 159
خرداد و تیر 1401
صفحه 12-23

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