تأثیر تمرین تناوبی سرعتی بر میزان پراکسیداسیون لیپیدی، ظرفیت آنتی اکسیدانی تام و فیبروز بافت قلب در موش‌ بزرگ آزمایشگاهی

نوع مقاله : مقاله پژوهشی

نویسندگان

گروه تربیت بدنی و علوم ورزشی، دانشکده علوم انسانی، دانشگاه شاهد، تهران ایران

چکیده

مقدمه و هدف: فعالیت ورزشی یکی از روش های کم هزینه و قابل دسترس برای کاهش خطر ابتلا به بیماری های قلبی-عروقی است. با این حال، تمرینات ورزشی با رویکرد سنتی از نظر زمانی کارآمد نیست. پژوهش حاضر با هدف بررسی تأثیر تمرین تناوبی سرعتی (SIT) با تکرارهای 10 ثانیه ای بر میزان مالون دی آلدهید (MDA)، ظرفیت آنتی اکسیدانی تام (TAC) و فیبروز بافت قلب در موش های بزرگ آزمایشگاهی سالم انجام گرفت.
مواد و روش ها: در این مطالعه تجربی، بیست سر موش بزرگ آزمایشگاهی نر بالغ (250-220 گرم) به صورت تصادفی به دو گروه کنترل (10=n, Co,) و تمرین SIT (10ST, n=) تقسیم شدند. گروه ST 5 هفته، پس از دوره آشناسازی یک هفته­ای و تست حداکثر سرعت، هفته­ای 3 جلسه تحت تمرین قرار گرفتند. میزان فیبروز، MDA و TAC بافتی قلب بررسی شد. داده­ها با آزمون آماری تی مستقل تحلیل شد
نتایج: درصد فیبروز بافتی قلب در گروه (64/0±34/4)ST نسبت به گروه (5/1± 8) CO به­طور معنی­داری کمتر بود (003/0=P). میانگین MDA بافت قلبی در گروه (mM 13/0± 5/1)ST نسبت به گروه CO (mM 22/0± 56/2) به­طور معنی­داری پایین­تر بود (P˂0.001). میانگین TAC در گروه ST (mM 10/0±27/1) نسبت به گروه CO (mM 60/0±74/0) به طور معنی­داری بالاتر بود (P˂0.001).
نتیجه گیری: بر پایه ی یافته های این پژوهش، SIT روش تمرین کم هزینه ی مناسبی برای قلب است که می تواند ضمن کمک به افزایش ظرفیت آنتی اکسیدانی تام، به کاهش میزان فیبروز بافت قلبی و MDA بینجامد.

کلیدواژه‌ها

عنوان مقاله [English]

The effect of sprint interval training on lipid peroxidation, total antioxidant capacity and heart tissue fibrosis in healthy rats

نویسندگان [English]

  • Mahshid Beyranvand
  • Mohammad Rahmani
Department of Exercise Sciences, Faculty of Humanities, Shahed University, Tehran, Iran
چکیده [English]

Background and Objective: Exercise is a low-cost and accessible way to reduce the risk of cardiovascular diseases. However, the traditional approaches of exercise are not time efficient. So, the aim of the present study was to investigate the effect of sprint interval training (SIT) on cardiac muscle fibrosis and malondialdehyde (MDA) levels, and total antioxidant capacity (TAC) in cardiac tissue of the healthy male Wistar rats.
 Materials and Methods: In this experimental study, twenty adult male wistar rats (250-220 g) were divided into two groups: control (n=10, Co) and SIT (n=10, ST). The training was performed for 5 weeks after a one-week familiarization period and maximum speed test. Cardiac fibrosis and tissue levels of MDA and TAC were assessed. The independent samples t-test was used for data analysis.
 Results: Results revealed that the tissue fibrosis percent was significantly lower in the ST group (4.34±0.64) compared to the Co (8±1.5) group (P=0.003). The MDA levels in the ST (1.5mM±0.13) was significantly lower than CO (2.56±0.22 mM) group (P˂0.001). Moreover, TAC level in ST group (1.27mM±0.10) was significantly higher than the CO group (0.74mM±0.06) (P˂0.001).
 Conclusion: Based on the findings of this study, SIT is a useful low-cost exercise method which may help reduce lipid peroxidation and cardiac fibrosis; additionally it may increase total antioxidant capacity in cardiac tissue

کلیدواژه‌ها [English]

  • Lipid peroxidation
  • Total antioxidant capacity
  • Myocardial fibrosis

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دانشور پزشکی
دوره 30، شماره 1 - شماره پیاپی 158
فروردین و اردیبهشت 1401
صفحه 84-94

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