نوع مقاله : مقاله پژوهشی
1 گروه تربیت بدنی و علوم ورزشی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران
2 دانشکده تربیت بدنی و علوم ورزشی، دانشگاه شهید بهشتی، تهران، ایران
عنوان مقاله [English]
Background and Objective: Exercise training and nutritional interventions such as L-arginine ingestion have an effective role in controlling hypertension. Therefore, the aim of present study was to investigate the effect of 12-weeks endurance training and L-arginine supplement on the levels of asymmetrical dimethylarginine (ADMA) and nitric oxide (NO) in hypertensive women.
Materials and Methods: 40 postmenopausal hypertensive women (55.26±2.56 years old, body mass index: 28.61±1.18 kg.m2) were randomly assigned in four groups (10 person) including: placebo, L-arginine, training and training+L-arginine groups. Endurance training program conducted for 12 weeks with 60-75 percent of maximum heart rate. L-arginine consumption considered 6 g daily. Blood sampling performed in pre and posttest (48 hours after last training session or L-arginine consumption) and ADMA and NO were measured by ELISA method. Data were analyzed by SPSS24 software and analysis of covariance test.
Results: ADMA in training and training+L-arginine groups indicated significant decrease compared to placebo and L-arginine groups (p < 0.05). NO levels significantly increased in all groups compared to placebo group (p < 0.05). Despite decrease in systolic blood pressure in L-arginine, training and training+L-arginine groups compared to placebo group (p < 0.001), decrease in systolic blood pressure in training+L-arginine group were significant compared to training (p < 0.001) and L-arginine (p=0.007) groups.
Conclusion: L-arginine consumption increases the effectiveness of endurance training in decreasing systolic blood pressure that is partly exerted by further increase in NO levels.