اثر تعاملی تمرین ورزشی و مصرف مکمل کورکومین و بر برخی از شاخص‌های آسیب بافت کبد موش‌های در معرض فلز سنگین سرب

نویسندگان

1 گروه فیزیولوژی ورزش،دانشکده علوم انسانی، دانشگاه آزاد ساری ،ایران.

2 گروه تربیت بدنی، دانشگاه آزاد واحد قائم شهر، قائم شهر،ایران.

3 گروه فیزیولوژی ورزش، دانشکده علوم انسانی، دانشگاه آزاد ساری،ایران.

چکیده

مقدمه و هدف: سرب می تواند منجر به آسیب کبدی از طریق  استرس اکسیداتیو گردد. فعالیت بدنی و استفاده از مواد ضد اکسایشی مانند کورکومین ممکن است تولید رادیکال های آزاد را متوقف می کند. لذا هدف از مطاله حاضر بررسی نقش حمایتی تمرین استقامتی  و کورکومین در مقابل اثرات سمی سرب بر آسیب بافت کبد موش های صحرایی نر بود.
 مواد و روش‌ها: در این تحقیق تجربی60 سر موش صحرایی نر به صورت تصادفی به 6 گروه کنترل، شم، سرب، تمرین+ سرب، کورکومین + سرب و تمرین+ سرب + کورکومین تقسیم شدند (10 سر موش در هر گروه). برنامه تمرینی شامل 8 هفته دویدن پیشرونده روی نوارگردان بدون شیب با سرعت 15 تا  22متر در دقیقه و به مدت 25 تا 64 دقیقه و 5 روز در هفته بود. مکمل کورکومین (30 میلی گرم / کیلوگرم) و سرب(20 میلی گرم / کیلوگرم) 3 روز در هفته و به صورت داخل صفاقی تزریق شد. فعالیتALT ، ASTوALP با روش رنگ سنجی آنالیز شدند.
 یافته‌ها: نتایج نشان داد 8 هفته تزریق سرب موجب افزایش معنی دار فعالیت AST وALP در گروه سرب نسبت به گروه کنترل شد(002/0=p، 001/0=p). انجام تمرین استقامتی همراه با مصرف کورکومین موجب کاهش معنی دار فعالیت AST وALP (005/0=p، 002/0=p)گردید. هم چنین فعالیت ALP پس از تمرین استقامتی و مصرف کورکومین کاهش غیر معنی دار یافت(302/0p=).
 نتیجه‌گیری: اجرای تمرین­های ورزشی و مصرف مکمل کورکومین، ممکن است سبب مهار آسیب کبدی ناشی از سمیت سرب شود.

کلیدواژه‌ها

عنوان مقاله [English]

The effect of fatigue and clinical course on depression, anxiety, stress, quality of life and employment status in patients with multiple sclerosis

نویسندگان [English]

  • Parvin Farzanegi 1
  • Masoumeh Habibian 2
  • Mohammad Salehi 3
1 Department of Exercise physiology, Faculty of Humanities, lslamic Azad University Sari
2 Department of Exercise physiology, Faculty of Humanities, lslamic Azad University Ghaem Shahr. Branch, Ghaem Shar, Iran
3 Department of Exercise physiology, Faculty of Humanities, lslamic Azad University Sari
چکیده [English]

Background and Objective: Fatigue is a common symptom in multiple sclerosis (MS) and most MS patients are of two types; relapsing-remitting (RRMS) and secondary progressive (SPMS). Fatigue with regard to feeling of weakness, lack of energy and clinical course due to the establishment of a variable prognosis can influence psychological symptoms, functional ability and employment status of patients. Thus, the aim of the present study was to evaluate the effect of fatigue and clinical course on psychological symptoms, physical and psychological dimensions, and employment status.
 Materials and Methods: In this retrospective cross-sectional study, 152 patients were sampled by consecutive method. All patients were evaluated using fatigue severity scale (FSS), depression, anxiety, and stress scale (DASS-21) and short form health survey questionnaire (SF-36). Data were analyzed using multivariate variance analysis (MANOVA) and Fisher exact test.
 Results: Mean of psychological symptoms and physical and psychological dimensions scores in fatigued and SPMS patients was worse than non-fatigued and RRMS groups.Also, un-employment was reported with higher frequency in fatigued patients. In this regard, no significant finding was observed between RRMS and SPMS. In addition, the difference between both groups of fatigued and non-fatigued, RRMS and SPMS patients was significant regarding the variables depression, anxiety, stress, and physical and psychological dimensions (p<0.05).
Conclusion: This study explained the impact of fatigue and clinical course on psychological symptoms, physical and psychological aspects of life and employment status of MS patients. However, it seems that the influence of some variables on each other in a bidirectional relationship is also explainable. Clinical implications have been discussed in this report.

کلیدواژه‌ها [English]

  • Fatigue
  • Depression
  • Anxiety
  • Quality of Life
  • Employment

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