تأثیر یک دوره تمرین استقامتی و مکمل یاری ال آرژنین بر عوامل مرتبط با سیستم انعقادی در زنان یائسه مبتلا به پرفشاری خون

نویسندگان

1 گروه تربیت بدنی و علوم ورزشی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران

2 دانشکده تربیت بدنی و علوم ورزشی، دانشگاه شهید بهشتی، تهران، ایران

چکیده

مقدمه و هدف: تمرین استقامتی و مکمل ال آرژنین نقش مؤثری در کنترل پرفشاری خون دارند؛ بنابراین، پژوهش حاضر با هدف بررسی تأثیر یک دوره تمرین استقامتی و مکمل یاری ال آرژنین بر عوامل مرتبط با سیستم انعقادی در زنان یائسه مبتلا به پرفشاری خون اجرا شد.
مواد و روش ها: تعداد 40 زن یائسه دارای پرفشاری خون (56/2±26/55 سال، شاخص توده بدن: 18/1±61/28 kg/m2) در گروه های دارونما، ال آرژنین، تمرین و تمرین+ال آرژنین قرار گرفتند. برنامه تمرین استقامتی به مدت 12 هفته با 75-60 درصد ضربان قلب بیشینه اجرا شد. مصرف ال آرژنین نیز روزانه 6 گرم بود. خون‌گیری در دو مرحله پیش آزمون و پس آزمون (48 ساعت بعد از جلسه آخر تمرین یا مصرف ال آرژنین) انجام و سطوح پلاسمایی بازدارنده فعال کننده پلاسمینوژن 1 (PAI-1)، فیبرینوژن و مولکول چسبان بین سلول (ICAM-1) اندازه گیری شد. تجزیه و تحلیل یافته ها با آزمون آنالیز کوواریانس و در سطح معناداری 05/0>p < /span> انجام شد.
نتایج: سطوح PAI-1 در گروه ال آرژنین، تمرین و تمرین+ال آرژنین در مقایسه با گروه دارونما و همچنین در گروه تمرین و تمرین+ال آرژنین در مقایسه با گروه ال آرژنین کاهش یافت. سطوح فیبرینوژن و ICAM-1 نیز در گروه تمرین و تمرین+ال آرژنین در مقایسه با گروه دارونما و ال آرژنین کاهش معناداری نشان داد. کاهش فشار خون سیستولی در گروه-های ال آرژنین، تمرین و تمرین+ال آرژنین در مقایسه با گروه دارونما، در گروه تمرین نسبت به گروه ال آرژنین و همچنین در گروه تمرین+ال آرژنین در مقایسه با گروه تمرین معنادار بود. علاوه بر این، کاهش فشار خون دیاستولی در گروه های تمرین و تمرین+ال آرژنین در مقایسه با گروه دارونما مشاهده شد.
نتیجه‌گیری: ال آرژنین علاوه بر اینکه به تنهایی نیز می تواند در کاهش فشار خون سیستولی و PAI-1 مؤثر باشد، می تواند تأثیر تمرین ورزشی در کاهش فشار خون سیستولی را افزایش دهد. به نظر می رسد که 12 هفته مصرف ال آرژنین نمی تواند تأثیری بر فیبرینوژن و ICAM-1 داشته باشد و کاهش فشار خون مستقل از این عوامل اتفاق می افتد.

کلیدواژه‌ها


عنوان مقاله [English]

Effect of one course endurance training and L-arginine supplementation on the coagulation system related factors in post-menopausal women with hypertension

نویسندگان [English]

  • Ronas Faryadi 1
  • Mandana Gholami 1
  • Khosrow Ebrahim 2
چکیده [English]

Background and Objective: Endurance training and L-arginine supplement play important role in hypertension management. Therefore, the present study aimed to investigate the effect of one course endurance training and L-arginine supplementation on the coagulation system related factors in post-menopausal women with hypertension.
Materials and Methods: The 40 post-menopausal women’s (55.26±2.56 years old, body mass index: 28.61±1.18 kg/m2) with hypertension divided in placebo, L-arginine, training and training+L-arginine groups. Endurance training program conducted for 12 weeks with 60-75 percent of maximum heart rate. L-arginine consumption was 6 gr daily. Blood sampling performed in pre and post test (48 hours after last training session or L-arginine consumption) and plasma levels of plasminogen activator inhibitor-1 (PAI-1), fibrinogen and intercellular adhesion molecule 1 (ICAM-1) levels were measured. Data were analyzed by analysis of covariance test at the P<0.05 significance level.
Results: The levels of PAI-1 in L-arginine, training and training+L-arginine groups compared to placebo group, also in training and training+L-arginine groups compared to L-arginine group significantly decreased. The levels of fibrinogen and ICAM-1 were also decreased significantly in training and training+L-arginine groups compared to placebo and L-arginine groups. Systolic blood pressure decreased significantly in L-arginine, training and training+L-arginine groups compared to placebo group, in training group compared to L-arginine group and in training+L-arginine group compared to training. Moreover, significant decrease in diastolic blood pressure in training and training+L-arginine groups compared to placebo group were observed.
Conclusion: L-arginine in addition to being effective in reducing systolic blood pressure and PAI-1 alone, can increase the effect of exercise training in decreasing systolic blood pressure. It seems that 12 weeks of L-arginine ingestion has no effect on the fibrinogen and ICAM-1 and decrease in blood pressure occurs independently of these factors.

کلیدواژه‌ها [English]

  • Hypertension
  • Coagulation system
  • Training
  • Post-menopausal
  • L-arginine
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