تأثیر درمان سوءهاضمه بر علائم بیماران مبتلا به کمردرد مزمن با استفاده از کپسول پونه

نویسندگان

1 گروه طب سنتی، دانشکدۀ پزشکی، دانشگاه علوم پزشکی اجا، تهران، ایران

2 مرکر تحقیقات کارآزمایی بالینی طب سنتی ، دانشگاه شاهد ،تهران، ایران

3 گروه جراحی اعصاب، دانشکده پزشکی، دانشگاه شاهد،تهران، ایران

4 گروه اپیدمیولوژی و آمار حیاتی ، دانشکده آمار ، دانشگاه علوم پزشکی زنجان ، زنجان

چکیده

مقدمه و هدف: کمردرد یکی از شایع‌ترین و پرهزینه‌ترین بیماری‌های مزمن می‌باشد که طب سنتی ایران با دیدگاه‌های درمانی غنی درخصوص درمان کمردرد، سوءهاضمه را به‌عنوان یکی از علل اصلی کمردرد مطرح کرده است. اگرچه همراهی کمردرد و سوءهاضمه در تحقیقات جدید تأیید شده است، ولی جهت بررسی ارتباط این دو بیماری تاکنون کارآزمایی بالینی انجام نشده است. هدف از انجام این طرح، بررسی تأثیر درمان سوءهاضمه بر علائم کمردرد می‌باشد.


مواد و روش‌ها: با بررسی 30 بیمار مبتلا به کمردرد مزمن بین 20 تا 55 سال که بیش از 12 هفته کمردرد داشتند و طبق کرایتریای ROM3 به سوءهاضمه نیز مبتلا بودند. تأثیر کپسول پونه به‌عنوان یک داروی مؤثر بر سوءهاضمه به‌مدت 4 هفته روزی 3 عدد بعد از وعده‌های غذایی در بیماران مورد مطالعه قرار گرفت. در هفته‌های صفر، دوم، چهارم و هشتم شدت درد با مقیاس سنجش مشاهده-عددی و ناتوانی عملکردی با پرسش‌نامۀ اسوستری و شدت سوءهاضمه با پرسش‌نامۀ لیدز بررسی گردید و نتایج آن‌ها با آزمون فریدمن بررسی شد و برای بررسی ارتباط شدت سوءهاضمه با میزان درد و ناتوانی ضریب پیرسون محاسبه گردید و سطح معناداری (05/0p < /span><) تعریف شد.


نتایج:  نتایج آزمون‌های آماری نشان داد کپسول پونه با کاهش شدت سوءهاضمه باعث کاهش درد و ناتوانی در بیماران مبتلا به کمردرد شده است.


نتیجه‌گیری: در بیماران مبتلا به کمردرد، توجه ویژه به مشکلات گوارشی ضروری می‌نماید

کلیدواژه‌ها


عنوان مقاله [English]

The impact of treatment of dyspepsia in patients with chronic low back pain by Mentha longifolia capsules

چکیده [English]

Background: Low back pain is one of the most common and most costly chronic diseases, which in many cases there is no cure for it . Iranian Traditional Medicine (TIM), has a valuable therapeutic perspectives for the treatment of low back pain. According to Iranian traditional medicine (TIM), One of the main causes of low back pain is dyspepsia. The aim of this study (by conducting a clinical trial) is to investigate the hypothesis that treatment of dyspepsia can reduce low back pain symptoms.


Materials and Methods: 30 patients between 20 and 55 years with chronic low back pain for more than 12 weeks were diagnosed according to the criteria ROM3 suffering from dyspepsia were enrolled.

Mentha longifolia capsules as a drug with positive effect in dyspepsia were given 3 times daily after meals for 4 weeks At the time of entry and after weeks 2, 4 and 8.  Visual analog pain scale(VAS) and Oswestry Functional Disability Questionnaire were used and severity of dyspepsia Leeds Questionnaire were checked out.


Results: Mentha longifolia capsule significantly reduced dyspepsia, and also pain and disability due to low back pain. (p<0.05).  Significant correlation between severity of dyspepsia and pain, and also between dyspepsia and disability from low back pain was observed.


Conclusion: Mentha longifolia capsule can reduce pain and disability by reducing dyspepsia. It is suggested to consider digestive problems, especially dyspepsia in patients with low back pain.

کلیدواژه‌ها [English]

  • Low-Back Pain
  • dyspepsia
  • Traditional Iranian Medicine (TIM)
  • Menta longifolia
1. Walsh K, Cruddas M, Coggon D. Low back pain in eight areas of Britain. Journal of Epidemiology and Community Health. 1992; 46(3): 227-30. 2. Hart LG, Deyo RA, Cherkin DC. Physician office visits for low back pain: frequency, clinical evaluation, and treatment patterns from a US national survey. Spine. 1995; 20(1): 11-9. 3. Khosravi A, Najafi F, Rahbar MR, Motlagh MA, Kabir MJ, indicators of health in the islamic republic of Iran, kermanshah university of medical sciences, Health research center 1388; 1. 4. Maetzel A, Li L. The economic burden of low back pain: a review of studies published between 1996 and 2001. Best Practice & Research Clinical Rheumatology. 2002; 16(1): 23-30. 5. Benoist M. The natural history of lumbar disc herniation and radiculopathy. Joint Bone Spine. 2002; 69(2): 155-60. 6. Yousefi M, Mahdavi MRV, Hosseini SM, Bahrami A, Davati A, Kamalinejad M, et al. Clinical Evaluation of Commiphora Mukul, a Botanical resin, in the Management of Hemorrhoids: A randomized controlled trial. Pharmacognosy magazine. 2013; 9(36): 350-9. 7. Mozaffarpur SA, Naseri M, Esmaeilidooki MR, Kamalinejad M, Bijani A. The effect of cassia fistula emulsion on pediatric functional constipation in comparison with mineral oil: a randomized, clinical trial. DARU Journal of Pharmaceutical Sciences. 2012; 20(1):83. 8. Ahmadiyya A, Treatment of rheumatism, gout and sciatica, Tehran, publications of Iqbal, 1381: 17-23. 9. ebne sina HA, Ghanoon, Beirut, Institute Alalmy Llmtbvat, 1391; 7-60, 123, 78-22. 10. Chashti MA, Eksir A, Institute for the History of Medicine, Islamic and Complementary Medicine 1387: 16. 11. Smith MD, Russell A, Hodges PW. How common is back pain in women with gastrointestinal problems? The Clinical journal of pain. 2008; 24(3): 199-203. 12. Hagen EM, Svensen E, Eriksen HR, Ihlebæk CM, Ursin H. Comorbid subjective health complaints in low back pain. Spine. 2006; 31(13): 1491-5. 13. Smith MD, Russell A, Hodges PW. Do incontinence, breathing difficulties, and gastrointestinal symptoms increase the risk of future back pain? The Journal of Pain. 2009; 10(8): 876-86. 14. Aghili khorasani MH, makhzanol adviye, 750, edited by movahed abtahi A, ghom Publication of hobb al matin, 2001; 131-133. 15. Marinova D, Ribarova F, Atanassova M. Total phenolics and total flavonoids in Bulgarian fruits and vegetables. Journal of the University of Chemical Technology and Metallurgy. 2005; 40(3): 255-60. 16. Beketov E, Pakhomov V, Nesterova O. Improved method of flavonoid extraction from bird cherry fruits. Pharmaceutical Chemistry Journal. 2005; 39(6): 316-8. 17. Drossman DA. The functional gastrointestinal disorders and the Rome III process. gastroenterology. 2006; 130(5): 1377-90. 18. Mousavi SJ, Parnianpour M, Mehdian H, Montazeri A, Mobini B. The Oswestry disability index, the Roland-Morris disability questionnaire, and the Quebec back pain disability scale: translation and validation studies of the Iranian versions. Spine. 2006; 31(14): E454-E9. 19. Summers S. Evidence-based practice part 2: reliability and validity of selected acute pain instruments. Journal of PeriAnesthesia Nursing. 2001; 16(1): 35-40. 20. Moayyedi P, Duffett S, Braunholtz D, Mason S, Richards I, Dowell A, et al. The Leeds Dyspepsia Questionnaire: a valid tool for measuring the presence and severity of dyspepsia. Alimentary Pharmacology and Therapeutics. 1998; 12(12): 1257-62. 21. Fanian H, Ghassemi GR, Jourkar M, Mallik S, Mousavi M. Psychological profile of Iranian patients with low-back pain. Eastern Mediterranean Health Journal2007; 13(2): 335-46. 22. Youdas JW, Garrett TR, Egan KS, Therneau TM. Lumbar lordosis and pelvic inclination in adults with chronic low back pain. Physical Therapy. 2000; 80(3): 261-75. 23. Nakipoglu GF, Karagoz A, Ozgirgin N. The biomechanics of the lumbosacral region in acute and chronic low back pain patients. Pain Physician. 2008; 11(4): 505-11. 24. Frerick H, Keitel W, Kuhn U, Schmidt S, Bredehorst A, Kuhlmann M. Topical treatment of chronic low back pain with a capsicum plaster. Pain. 2003; 106(1): 59-64. 25. Shamsi M, Rezaie s, Risk factors for low back pain patients have been referred to Health centers in Kermanshah. 2000;10(1): 57-67. 26. Saftić R, Grgić M, Ebling B, Splavski B. Case-control study of risk factors for lumbar intervertebral disc herniation in Croatian island populations. Croatian medical journal. 2006; 47(4): 593-600. 27. Chrubasik S, Künzel O, Model A, Conradt C, Black A. Treatment of low back pain with a herbal or synthetic anti‐rheumatic: a randomized controlled study. Willow bark extract for low back pain. Rheumatology. 2001; 40(12): 1388-93. 28. Guclu DG, Guclu O, Ozaner A, Senormanci O, Konkan R. The relationship between disability, quality of life and fear-avoidance beliefs in patients with chronic low back pain. Turkish neurosurgery. 2011; 22(6): 724-31. 29. Ritter R, Schatton W, Gessner B, Willems M. Clinical trial on standardised celandine extract in patients with functional epigastric complaints: results of a placebo-controlled double-blind trial. Complementary Therapies in Medicine. 1993; 1(4): 189-93. 30. Talley NJ, Choung RS. Whither dyspepsia, A historical perspective of functional dyspepsia, and concepts of pathogenesis and therapy in 2009. Journal of gastroenterology and hepatology. 2009; 24(s3): S20-S8.