The effect of eight weeks of inactivity after a combined training period on the expression of miR-155 and TLR-4 genes in women with multiple sclerosis (MS)

Yousefi Saghezi, Saman; Alizadeh Pahlavani, Hamed

doi:10.22070/daneshmed.2026.21739.1688

The effect of eight weeks of inactivity after a combined training period on the expression of miR-155 and TLR-4 genes in women with multiple sclerosis (MS)

Articles in Press

Document Type : Original Article

Authors

Saman Yousefi Saghezi

hamed alizadeh pahlavani

Department of Physical Education, Farhangian University, P.O. Box 14665-889, Tehran, Iran

10.22070/daneshmed.2026.21739.1688

Abstract

Introduction: The aim of this study was to investigate the effect of eight weeks of detraining after combined training on the expression of miR-155 and TLR-4 in women with relapsing-remitting MS (RRMS).
Methods: From a population of 90, 22 women with RRMS were randomly assigned to the experimental and control groups. The experimental group performed eight weeks of combined training (aerobic and resistance training); then, they were detrained for eight weeks. The expression levels of TLR-4 and miR-155 were measured by RT-PCR before and after training and after detraining.
Findings: The data showed that the expression levels of miR-155 and TLR-4 were significantly lower than the control group after the exercise intervention (P=0.001) and after the detraining period (P=0.02). The difference in EDSS score was significant after combined training (P=0.015) and no training (P=0.018).
Conclusion: It seems that the anti-inflammatory effects of combined training in women with RRMS are very fragile compared to no training. Therefore, regular exercise is recommended for patients with RRMS.

Keywords

lack of exercise

combined exercise

miR-155

TLR-4

multiple sclerosis

Subjects