Background and Objective: Lung cancer is one of the most common and serious types of cancer. The present study was done to examine the effect of swimming training and consumption of royal jelly on inflammatory factors of lung tissue in mice with lung cancer.
Material and Methods: In this experimental study, 36 male Balb/c mice were divided into sham, healthy control, lung cancer, swimming training, royal jelly and training + royal jelly randomly. Lung cancer induced by injection of 100 mg/kg Benzo[a]pyrene. Swimming training was performed 5 days a week for 12 weeks. Royal jelly was also received as an intraperitoneal injection at a dose of 100 mg/kg for 12 weeks and five times a week. 48 h after the last training session, gene expression of LPS-induced IKB-Z and IL-6 was measured using Real-Time PCR method.
Results: LPS-induced IKB-Z and IL-6 gene expression was significantly increased in the mice of the lung cancer group compared to the healthy control group (p=0.001). The expression of these two genes was lower in the swimming training, royal jelly and training + royal jelly groups compared to the lung cancer group (p=0.01), but the interaction effect of training and royal jelly supplementation on their reduction was not significant.
Conclusion: According the study results, it seems that swimming training and royal jelly supplement can create a protective potential against inflammation and lung cancer in animal samples.