Correlation Between History of Infant Colic and Migraine in Children Referred to Children's Neurology Clinics in Urmia in 1402

Document Type : Original Article

Authors

1 Department of pediatrics disease, School of medicine, Urmia University of medical science, Urmia, Iran

2 Department of pediatric diseases, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

3 Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

Abstract

Background and Objective: Infantile colic is a prevalent condition during the first three months of an infant's life. Migraine is a frequent cause of recurrent primary headache in childhood. The pathogenesis of infantile colic and migraine remains unclear. However, evidence suggests an association between childhood and adolescent migraine headaches and infantile colic. This study aimed to investigate the association between a history of infantile colic and migraine in children referred to the Urmia Pediatric Neurology Clinics.
Materials and Methods: This cross-sectional analytical study was conducted on 200 children aged 6–18 years who were referred to Urmia Pediatric Neurology Clinics in 1402. Participants were divided into two groups: those with migraine headaches (n=100) and those without (n=100), serving as the case and control groups, respectively. Data were collected through parental interviews and medical records. Statistical analyses were performed using independent t-tests and Fisher's exact test.
Results: The mean age of the children with migraine was 11.3±3.2 years, with 52% being male. No significant differences in age or sex were observed between the case and control groups (P=0.277 and P=0.202, respectively). The results indicated a significant association between infantile colic (P<0.001), family history of migraine (P<0.001), and the presence of infantile colic in another child in the family (P<0.001) with the likelihood of developing migraine headaches in the future.
Conclusion: This study provides evidence that infantile colic, a family history of migraine, and the occurrence of infantile colic in another child in the family are associated with an increased likelihood of developing migraine headaches in childhood and adolescence. However, owing to the study's limitations, including its retrospective nature and potential recall bias, further research is necessary to corroborate these findings.

Main Subjects

Daneshvar Medicine

Articles in Press, Accepted Manuscript
Available Online from 02 August 2025

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