Daneshvar Medicine

Daneshvar Medicine

The effect of losartan on cardiac hypertrophy and serum lipid profile in the aging model induced by D-galactose in rats

Document Type : Original Article

Authors
Amir Hossein Shamsi 1
Farnaz Fariba 2
Siamak Shahidi 3
Abdolrahman Sarihi 4
Fatemeh Ramezani-Aliakbari 3
1 Medical School, Hamadan University of Medical Sciences, Hamadan, Iran
2 Department of Cardiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3 Department of Physiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
4 Department of Neuroscience, School of Sciences and Advanced Technology in Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
10.22070/daneshmed.2024.19253.1507
Abstract
Background and Objective: Aging is a major risk factor for developing cardiovascular diseases. Losartan is an antihypertensive drug that has shown promising effects in improving cardiovascular diseases. The aim of this study was to investigate the effect of Losartan on cardiac hypertrophy, cardiac damage markers including lactate dehydrogenase (LDH) and cardiac creatine kinase (CK-MB), and lipid profile due to D-galactose induced aging model in male rats.
Materials and Methods: The rats were randomly divided into 3 groups, with 8 rats in each group, including the control group, the aged group induced with D-galactose, and the aged group induced with D-galactose and receiving Losartan. Cardiac hypertrophy was measured by histological examination and measurement of heart weight and body weight. Also, serum lipid profile and heart damage markers were measured.
Results: The findings showed that aging induced by D-galactose causes cardiac hypertrophy, hyperlipidemia and increased serum levels of heart damage markers. In addition, treatment with Losartan decreased cardiac hypertrophy, decreased cholesterol, decreased low density lipoprotein (LDL), and decreased cardiac injury markers in aged rats.
Conclusion: The results of the present study show that Losartan is effective in improving cardiac hypertrophy and reducing heart damage caused by D-galactose-induced aging, which is partially done by improving lipid profile.
Keywords
Aging
Losartan
Hypertrophy
Lactate Dehydrogenase
Creatine Kinase
Subjects
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Daneshvar Medicine
Volume 32, Issue 3 - Serial Number 172
September and October 2024
Pages 1-11