Daneshvar Medicine

Daneshvar Medicine

The synergistic role of aerobic training and resveratrol consumption on the pathway of hippocampal mitochondrial biogenesis in rats with Alzheimer's disease

Document Type : Original Article

Authors
Ammar Rashet
Ahmad Abdi
Alireza Barari
Department of Physical Education and Sport Science, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran
10.22070/daneshmed.2024.19127.1494
Abstract
Background and Objective: The pathogenesis of AD shows that the imbalance between the production and clearance of amyloid-β (Aβ) is the cause of the development of dementia. Exercise reduces Aβ deposition through the AMPK signaling pathway. In addition, resveratrol (RSV) has neuroprotective effects associated with cognitive decline. The aim of the present study was to investigate the effect of aerobic training and RSV consumption on the AMPK/PGC-1α/SIRT1 pathway in the hippocampus of rats with Alzheimer's disease.
Materials and Methods: In this experimental study, 35 male Wistar rats were divided into 5 groups: Control (NO), Alzheimer's (AD), Alzheimer's-Training (ADT), Alzheimer's-Resveratrol (ADRSV) and Alzheimer's-Training-Resveratrol (ADTRSV). The supplement groups received 20 mg of RSV (per kg of body weight) orally during the intervention period. Aerobic exercise program including running on treadmill with a speed of 6-18 meters per minute, was performed 5 days a week for eight weeks.
Results: AD induction caused a significant decrease in the gene expression of AMPK/PGC-1α/SIRT1 (p=0.0001). Exercise and RSV significantly increased the gene expression of AMPK/PGC-1α/SIRT1 in AD rats (p<0.05). Also, a significant increase was observed in the gene expression changes of AMPK, PGC-1α and SIRT1 in the ADTRSV group compared to the ADT group (p=0.034, p=0.020 and p=0.038, respectively) and ADRSV (p=0.026, p=0.021 and p=0.021).
Conclusion: AD induction was associated with a decrease in AMPK/PGC-1α/SIRT1 gene expression, and aerobic exercise and RSV consumption can reverse this process. It seems that changing the levels of these indicators following physical activity and the use of RSV can partially reduce the complications of AD.
Keywords
Exercise
Resveratrol
Mitochondrial biogenesis
Alzheimer's disease
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Daneshvar Medicine
Volume 32, Issue 2 - Serial Number 171
July and August 2024
Pages 52-62