Effect of gold nanoparticles synthesized by microalgae Spirulina platensis on oxidative stress indices in rats fed with high fat diet

Document Type : Original Article

Authors

1 Department of Marine Biology, Faculty of Marine Science and Technology, University of Hormozgan, Bandar Abbas, Iran

2 Department of Biomaterials, Nanotechnology and Tissue Engineering, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background and Objective: Given the significance of gold nanoparticles and spirulina microalgae in pharmaceuticals, it is essential to explore their impact in diverse areas of biomedicine. This research aimed to investigate the effect of gold nanoparticles synthesized by the microalgae Spirulina platensis on oxidative stress indices in large Albino laboratory rats fed a high-fat diet.
Materials and Methods: Gold nanoparticles were synthesized using the aqueous extract of Spirulina platensis. In the continuation of the experiment, 30 large white laboratory rats were divided into five groups. These included the control group, which was fed standard pellet food, the model group, which was fed a high-fat diet without any treatment, and three other experimental groups. These experimental groups were fed high-fat food containing biosynthesized nanoparticles in two different doses, as well as a group that was fed only with spirulina microalgae.
Results: According to the results, the optimal synthesis occurred at a wavelength of 540 nm and a temperature of 40°C. Additionally, the nanoparticles displayed a spherical shape. This study showed a significant increase in SOD, GPx, and CAT levels in the HFD+Au-Sp (high dose) and HFD+Spirulina groups compared to the model group. In addition, the levels of malondialdehyde were significantly reduced in both the HFD+The Au-Sp (high dose) and HFD+Spirulina groups compared to the model group.
Conclusion: The results indicate that the extract of Spirulina platensis is a suitable biological source for synthesizing gold nanoparticles, making it an ideal material for medical applications.

Keywords

Main Subjects

References

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Daneshvar Medicine
Volume 32, Issue 1 - Serial Number 170
March and April 2024
Pages 1-16

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