The effect of resistance training on serum amyloid A protein levels and insulin resistance in sedentary obese women

Document Type : Original Article

Authors

Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran

Abstract

Background and Objective: Serum amyloid A (SAA) is an inflammatory factor which has an important role in pathogenesis of insulin resistance. Aim of present study was to investigate the effect of 12 weeks resistance training on serum amyloid A protein levels and insulin resistance in sedentary obese women.
Materials and Methods: 24 sedentary obese women aged 20 to 35 years old assigned to control (12 person) and resistance training (12 person) groups. Resistance training program completed during 12 weeks/ three sessions per week with 75 percent of 1 repetition maximum (1RM) and four sets with 8-12 repetitions. Before starting training program and two days after last training session, blood samples collected and SAA, glucose and insulin levels were measured. Present findings analyzed with SPSS software version 24. Analysis of covariance test were used for comparing groups changes, and intra-group changes determined using paired t test.
Results: According to study findings, serum levels of SAA in resistance training program group compared to control group significantly decreased (p=0.015). In addition, significant decrease in insulin resistance in resistance training group compared to control group was observed (p=0.001). Intra-group analysis represented a significant decrease in SAA levels in the resistance training group (p=0.048) and non-significant changes in the control group (p=0.389).
Conclusion: The resistance training program leads to the improvement of insulin resistance in obese women by reducing the levels of inflammatory factors such as SAA. Nevertheless, identifying the mechanisms of reducing SAA levels by exercise training requires further investigation.

Keywords

References

  1. Jastreboff AM, Kotz CM, Kahan S, Kelly AS, Heymsfield SB. Obesity as a disease: the obesity society 2018 position statement. Obesity 2019; 27(1):7-9.
  2. Manrique-Acevedo C, Chinnakotla B, Padilla J, Martinez-Lemus LA, Gozal D. Obesity and cardiovascular disease in women. International Journal of Obesity 2020; 44(6):1210-26.
  3. Blüher M. Obesity: global epidemiology and pathogenesis. Nature Reviews Endocrinology 2019; 15(5):288-98. 
  4. Fasshauer M, Blüher M. Adipokines in health and disease. Trends in Pharmacological Sciences 2015; 36(7):461-70.
  5. Vekic J, Zeljkovic A, Stefanovic A, Jelic-Ivanovic Z, Spasojevic-Kalimanovska V. Obesity and dyslipidemia. Metabolism 2019; 92:71-81.
  6. Liang W, dong Ye D. The potential of adipokines as biomarkers and therapeutic agents for vascular complications in type 2 diabetes mellitus. Cytokine & growth Factor Reviews 2019; 48:32-9.
  7. Su X, Peng D. Adipokines as novel biomarkers of cardio-metabolic disorders. Clinica Chimica Acta 2020; 507:31-8.
  8. Webb NR. High-Density Lipoproteins and Serum Amyloid A (SAA). Current Atherosclerosis Reports 2021; 23(2):1-8.
  9. Yang RZ, Lee MJ, Hu H, Pollin TI, Ryan AS, Nicklas BJ, et al. Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complications. PLOS Medicine 2006; 3(6): e287.
  10. Shridas P, Tannock LR. Role of serum amyloid A in atherosclerosis. Current Opinion in Lipidology 2019; 30(4):320-25.
  11. Zhou J, Sheng J, Fan Y, Zhu X, Tao Q, He Y, Wang S. Association between serum amyloid A levels and cancers: a systematic review and meta-analysis. Postgraduate Medical Journal 2018; 94(1115):499-507.
  12. Yang RZ, Blumenthal JB, Glynn NM, Lee MJ, Goldberg AP, Gong DW, et al. Decrease of circulating SAA is correlated with reduction of abdominal SAA secretion during weight loss. Obesity 2014; 22(4):1085-90.
  13. Vietri L, Fui A, Bergantini L, d’Alessandro M, Cameli P, Sestini P, Rottoli P, Bargagli E. Serum amyloid A: A potential biomarker of lung disorders. Respiratory Investigation 2020; 58(1):21-7.
  14. Wilson PG, Thompson JC, Shridas P, McNamara PJ, de Beer MC, de Beer FC, et al. Serum amyloid A is an exchangeable apolipoprotein. Arteriosclerosis, Thrombosis, and Vascular Biology 2018; 38(8):1890-900.
  15. Eklund KK, Niemi K, Kovanen PT. Immune functions of serum amyloid A. Critical Reviews in Immunology 2012; 32(4): 335-48.
  16. Wang Z, Nakayama T. Inflammation, a link between obesity and cardiovascular disease. Mediators of inflammation 2010; 535918.
  17. You T, Arsenis NC, Disanzo BL, LaMonte MJ. Effects of exercise training on chronic inflammation in obesity. Sports Medicine 2013; 43(4):243-56.
  18. Saghebjoo M, Nezamdoost Z, Saffari I, Hamidi A. The effect of twelve weeks of aerobic training on serum levels of interleukin-6, vaspin and serum amyloid A in postmenopausal women with metabolic syndrome. Scientific Journal of Kurdistan University of Medical Sciences 2017; 21(6):44-54.
  19. Ogawa K, Sanada K, Machida S, Okutsu M, Suzuki K. Resistance exercise training-induced muscle hypertrophy was associated with reduction of inflammatory markers in elderly women. Mediators of inflammation 2010; 171023.
  20. Gholaman M, Gholami M, Azarbayjani MA, Abed Natanzi H. High and Moderate Intensity Aerobic Training Effects on Galectin-3, Pentraxin-3, and Several Inflammatory Mediators Levels in Type 2 Diabetic Women, a Randomized Clinical Trial. Women’s Health Bulletin 2021; 8(4):238-46.
  21. Ghanbari-Niaki A, Saeidi A, Ahmadian M, Gharahcholo L, Naghavi N, Fazelzadeh M, et al. The combination of exercise training and Zataria multiflora supplementation increase serum irisin levels in postmenopausal women. Integrative Medicine Research 2018; 7(1):44-52.
  22. Nayebifar SH, Ghasemi E, Karimipour S. Effect of high-intensity interval training and omega-3 supplementation on liver enzymes and lipid profile of young men. Science & Sports 2020; 35(1):e1-9.
  23. Abdul-Hameed U, Rangra P, Shareef MY, Hussain ME. Reliability of 1-repetition maximum estimation for upper and lower body muscular strength measurement in untrained middle-aged type 2 diabetic patients. Asian Journal of Sports Medicine 2012; 3(4):267-73.
  24. Piché ME, Tchernof A, Després JP. Obesity phenotypes, diabetes, and cardiovascular diseases. Circulation Research 2020; 126(11):1477-500.
  25. Lu J, Yu Y, Zhu I, Cheng Y, Sun PD. Structural mechanism of serum amyloid A-mediated inflammatory amyloidosis. Proceedings of the National Academy of Sciences 2014; 111(14):5189-94.
  26. Poitou C, Coussieu C, Rouault C, Coupaye M, Cancello R, Bedel JF, et al. Serum amyloid A: a marker of adiposity‐induced low‐grade inflammation but not of metabolic status. Obesity 2006; 14(2):309-18.
  27. Yassine HN, Trenchevska O, He H, Borges CR, Nedelkov D, Mack W, et al. Serum amyloid a truncation in type 2 diabetes mellitus. PloS One 2015; 10(1): e0115320.
  28. Ye XY, Xue YM, Sha JP, Li CZ, Zhen ZJ. Serum amyloid A attenuates cellular insulin sensitivity by increasing JNK activity in 3T3-L1 adipocytes. Journal of Endocrinological Investigation 2009; 32(7):568-75.
  29. Kolahdouzi S, Baghadam M, Kani-Golzar FA, Saeidi A, Jabbour G, Ayadi A, et al. Progressive circuit resistance training improves inflammatory biomarkers and insulin resistance in obese men. Physiology & Behavior 2019; 205:15-21.
  30. Safarzade A, Basiri A. Changes in plasma acute phase proteins (SAA and CRP) levels following 8 weeks of circuit resistance training in obese men. Metabolism and Exercise A Bioannual Journal 2015; 4(2): 109-120.
  31. Campbell PT, Campbell KL, Wener MH, Wood B, Potter JD, Mctiernan AN, et al. A yearlong exercise intervention decreases CRP among obese postmenopausal women. Medicine and Science in Sports and Exercise 2009; 41(8): 1533-9.
  32. Pitsavos C, Panagiotakos DB, Chrysohoou C, Kavouras S, Stefanadis C. The associations between physical activity, inflammation, and coagulation markers, in people with metabolic syndrome: the ATTICA study. European Journal of Preventive Cardiology 2005; 12(2):151-8.
  33. Jamshidi Rad F, Nikoofar M, Nayebifar Sh. Effectiveness of 8 Weeks Aerobic Training and Nano Curcumin Supplementation on Serum Amyloid A Protein Content and Body Composition in Overweight and Obese Women. Journal of North Khorasan University of Medical Sciences 2020;12(2):1-8.
  34. Zhao Y, He X, Shi X, Huang C, Liu J, Zhou S, et al. Association between serum amyloid A and obesity: a meta-analysis and systematic review. Inflammation Research 2010; 59(5):323-34.
  35. Salama AA, Amine EK, Salem HA, Abd El Fattah NK. Anti-inflammatory dietary combo in overweight and obese women with polycystic ovary syndrome. North American Journal of Medical Sciences. 2015; 7(7):310-6.
  36. Ryan AS, Ge S, Blumenthal JB, Serra MC, Prior SJ, Goldberg AP. Aerobic exercise and weight loss reduce vascular markers of inflammation and improve insulin sensitivity in obese women. Journal of the American Geriatrics Society 2014; 62(4):607-14.
  37. Porter Starr KN, Orenduff M, McDonald SR, Mulder H, Sloane R, Pieper CF, et al. Influence of weight reduction and enhanced protein intake on biomarkers of inflammation in older adults with obesity. Journal of Nutrition in Gerontology and Geriatrics 2019; 38(1):33-49.
  38. Scheja L, Heese B, Zitzer H, Michael MD, Siesky AM, Pospisil H, et al. Acute-phase serum amyloid A as a marker of insulin resistance in mice. Experimental Diabetes Research 2008;230837.
  39. Zhang Y, Zhang J, Sheng H, Li H, Wang R. Acute phase reactant serum amyloid A in inflammation and other diseases. Advances in Clinical Chemistry 2019; 90:25-80.
  40. Wang Y, Cao F, Wang Y, Yu G, Jia BL. Silencing of SAA1 inhibits palmitate-or high-fat diet induced insulin resistance through suppression of the NF-κB pathway. Molecular Medicine 2019; 25(1):17.
  41. Olefsky JM, Glass CK. Macrophages, inflammation, and insulin resistance. Annual Review of Physiology 2010; 72:219-46.
  42. Roberts CK, Hevener AL, Barnard RJ. Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training. Comprehensive Physiology 2013; 3(1):1-58.
  43. Yaribeygi H, Atkin SL, Simental‐Mendía LE, Sahebkar A. Molecular mechanisms by which aerobic exercise induces insulin sensitivity. Journal of Cellular Physiology 2019; 234(8):12385-92.
Daneshvar Medicine
Volume 30, Issue 3 - Serial Number 160
September and October 2022
Pages 72-83

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