Daneshvar Medicine

Daneshvar Medicine

The effect of 8 weeks of endurance training on the antioxidant system of glutathione and malondialdehyde in rats with rheumatoid arthritis

Document Type : Original Article

Authors
Abbas Saremi 1
Reyhanh Norouzi 1
Mohamad Parastesh 1
Zahra Yousefvand 1
Saeed Tahmasebi 2
1 Department of Sport Physiology, Faculty of Sport Sciences, Arak University, Arak, Iran
2 Department of Physiology, Faculty of Basic Sciences, Arak Azad University, Arak, Iran
10.22070/daneshmed.2022.15623.1163
Abstract
Background and Objective: Elevated free radical generation in inflamed joints and impaired antioxidant system has been implicated in rheumatoid arthritis (RA). Evidence suggests that exercise improves the symptoms of rheumatoid arthritis, although the mechanism is not well understood. The aim of this study was to investigate the effect of endurance training on the glutathione antioxidant system and oxidative changes induced by rheumatoid arthritis in rats.
Materials and Methods: In this study, 30 Wistar laboratory rats with an average weight of 200-250 grams were randomly assigned into three groups: healthy control group(C), arthritis control (RA+C) and arthritis and endurance training group (RA+EX)(n=10). The training groups had trained the exercise program for 8 weeks by treadmill. Data were analyzed using one-way ANOVA and Tukey post-hoc test at a significance level of 0.05.
Results: The results showed, levels of malondialdehyde increased  by rheumatoid arthritis significantly, and endurance training prevented this response (P<0.05). Also, glutathione peroxidase and glutathione reductase were significantly decreased in the RA+C group compared to the RA+EX and C groups (P<0.05). In addition, the severity of rheumatoid arthritis clinical signs in RA+EX group was significantly lower than RA+C group (P<0.05).
Conclusion: Our findings suggest that endurance training may be useful in preventing the negative changes in glutathione antioxidant system and oxidative stress parameters related to rheumatoid arthritis.
Keywords
Rheumatoid arthritis
Endurance training
Malondialdehyde
Glutathione
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Daneshvar Medicine
Volume 30, Issue 2 - Serial Number 159
July and August 2022
Pages 83-93