Daneshvar Medicine

Daneshvar Medicine

The effect of high intensity interval training on myostatin and SMAD2/3 proteins in the left ventricular tissue of the heart muscle of type 1 diabetic rats

Document Type : Original Article

Authors
Masoud Jokar 1
Mohammad Sherafati Moghadam 2
Mousa Amirahmadi 3
1 Department of Physical Education and Sport Sciences, Kharazmi University, Tehran, Iran
2 2. Department of Sport Sciences, Apadana Institute of Higher Education, Shiraz, Iran
3 Department of Sport Sciences, School of Education and Psychology, University of Shiraz, Shiraz, Iran
10.22070/daneshmed.2021.13526.1011
Abstract
< p >Background and Objective: Disruption of the myostatin/SMAD pathway can lead to heart failure. Diabetes can disrupte this pathway. Therefore, the present study aimed to evaluate the effect of six weeks of high-intensity interval training HIIT (on myostatin and SMAD2/3 proteins in the left ventricular tissue of the heart muscle of type 1 diabetic rats.
Materials and Methods: In this study, 12 Spragodoli male rats (2-month old) with a mean weight of 300±20 g were selected.  Through streptozotocin solution, they were randomly divided into 2 groups: diabetic endurance training (6 heads) and diabetic control (6 heads); The training groups performed the training program 4 days a week for 6 weeks, including 5 interval 4-minute with an intensity of 85 to 95% of the maximum speed, and 3-minute active rest periods with an intensity of 50 to 60% of the maximum speed; Independent t-test was used to analyze the data.
Results: Six weeks of HIIT training lead to a significant reduction in myostatin protein content between training and control groups in myocardial tissue (P=0.044). Also, HIIT training resulted in a significant decrease in SMAD2/3 protein content between training and control groups in myocardial tissue (P=0.001).
Conclusion: It can be said that HIIT training by reducing the content of myostatin and SMAD2/3 proteins in the left ventricle of the heart has been able to prevent cardiac atrophy in type 1 diabetic subjects. This reduction can lead to physiological cardiac hypertrophy.
Keywords: Cardiac muscle, High intensity interval training, Myostatin 
Keywords
Cardiac muscle
High intensity interval training
Myostatin protein
SMAD2/3 protein
Type 1 diabetes
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Daneshvar Medicine
Volume 29, Issue 2 - Serial Number 153
July and August 2021
Pages 21-30