Background and Objective: Recent studies have demonstrated the obese–induced oxidative stress
and inflammation are risk factors for breast cancer. The aim of this study was
to determine the relationship of the pro-inflammatory markers, lipid
peroxidation and body fat percentage after 6 weeks of regular water-based
exercise and ginger supplement in obese women
with breast cancer. 
Materials and Methods: In a
semi-experimental study, forty obese women diagnosed with breast cancer with
weight 76±9 kg and fat mass of 41.8±4 percent were randomly divided into four
groups: placebo, water-based exercise, ginger supplement and a combined group
of water-based exercise and ginger supplement. Subjects of the ginger
supplement and combined group were receiving 4 capsules of ginger powder on a
daily basis (each capsule contained 750 mg), for 6 weeks. The water-based
exercise training program was collected at a progressive intensity and time: 4
times a week for 6 weeks.     Results: Implementation
of water-based exercise, ginger supplement and the combined programs caused a
significant decrease in concentration of interleukin -6
(IL-6) and C-reactive protein (CRP), malondialdehyde (MDA) and fat mass.
However, considering Pearson correlation coefficient, it was concluded that
just the relationship between fat mass and MDA in the ginger supplement group
was significant (r= 0.63, p= 0.05).   Conclusion: Although performing water-based
exercise and ginger supplement programs attenuate systemic inflammation and
oxidative stress in obese women with breast cancer, there was no relationship between stress and changes of pro-inflammatory markers.