The effect of chronic carnosine treatment on serum levels of glucose and lipids and blood pressure in an experimental model of hyperlipidemia in mice

Authors

Abstract

 Background and Objective: Chronic hyperlipidemia accompanies
various complications in the body. With regard to protective and beneficial
effect of carnosine in metabolic disorders, this study was conducted to
evaluate its effect on serum lipids and blood pressure in an experimental model
of hyperlipidemia in mice.  Materials and Methods: Mice were divided into five groups,
i.e. control, high-dose carnosine-treated control, hyperlipidemic, and two
carnosine-treated (125 and 250 mg/kg) hyperlipidemic groups. Carnosine was
administered i.p. from 8th week after hyperlipidemia induction for 4 weeks.  Results: Carnosine did not cause any
significant reduction of serum glucose, there was a significant increase in
serum total cholesterol and triglyceride in hyperlipidemic group as compared to
control (p < 0.05-0.01) and carnosine at a high dose significantly decreased
it (p < 0.05). Regarding serum HDL cholesterol, carnosine treatment did not significantly
change it. In contrast, hyperlipidemia significantly increased LDL-cholesterol
(p < 0.05) and carnosine at a dose of 250 mg/kg significantly lowered it
(p < 0.05). In addition, hyperlipidemic mice has a significantly higher
systolic blood pressure (p < 0.05) and carnosine treatment did not
significantly change it. Conclusion: Administration of carnosine to
hyperlipidemic mice does not affect serum glucose level and systolic blood
pressure and significantly lowers serum total cholesterol, LDL-cholesterol, and
triglyceride level. 

Keywords

Daneshvar Medicine
Volume 20, Issue 4 - Serial Number 101
September and October 2012
Pages 9-16

Files

Share

How to cite

Statistics