Evaluation of antioxidant and antibacterial effect of methanolic extract from thyme (Thymus vulgar), senna (Cassia angustifolia) and licorice (Glycyrrhiza glabra)

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Abstract

 Background and Objective: Thymus vulgar, Cassia
angustifolia and Glycyrrhiza glabra are widely used in the East Azerbaijan folk
medicine. Effective compounds present in these plants could be candidates for some
of their biological activities and therefore for their therapeutic uses. In
this study, methanolic extract of these plants was used to detect their antioxidant
and antimicrobial activity.   Materials and Methods: Methanolic
extract of the dried powder was obtained by maceration method. Then, the
solvent was removed by rotary evaporator. As antioxidant activity test,
superoxide anion radical scavenging level was measured by a pyrogallol auto-oxidation
system. The antibacterial activity
of methanolic extract of these plants was tested by disc diffusion method
against 3 enteric microorganisms. The minimal inhibitory concentrations (MIC) and
the minimum
bactericidal concentration (MBC) of methanolic extracts were also
determined.    Results: The antioxidant activity of methanolic
extract of Thymus was dose-dependent The Cassia also showed antioxidant
properties in small quantities, but no specific antioxidant activity of
Glycyrrhiza extract was observed. The three microorganisms were
sensitive to the methanolic extract of these plants and
showed 4 to 15 mm zone of inhibition.    Conclusion: Thyme has
both stronger antioxidant and antibacterial activities than the other two plants. Generally, different results obtained for each plant depend on
several factors such as amount of active ingredients contained in each plant
and it also depends on genus and the family of plants, type of solvent and extraction
method. 

Keywords

Daneshvar Medicine
Volume 20, Issue 3 - Serial Number 100
July and August 2012
Pages 57-66

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