Document Type : Original Article
Authors
1
Department of Exercise Physiology, Faculty of Psychology and Educational Sciences, University of Mohaghegh Ardabili, Ardabil, Iran
2
Department of Exercise Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran
3
Department of Exercise Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran.
4
Department internal medicine Or department endocrinology , Arak University of Medical Sciences, Arak, Iran
Abstract
The objective of the present study was to investigate the effects of combined resistance and endurance exercise training on serum levels of the biomarkers MuRF-1 and Atrogin-1, as well as other diabetes-related biomarkers, in middle-aged women diagnosed with type 2 diabetes.
This quasi-experimental study involved thirty women diagnosed with type 2 diabetes. After a thorough review of medical records and assessment of inclusion criteria, participants were randomly assigned to either a combined training group (CT) or a control group (CO). The exercise group underwent a structured training protocol three times a week for a duration of eight weeks. Blood samples were collected pre- and post-intervention by a qualified laboratory specialist and were analyzed using human ELISA kits. Data analysis was conducted utilizing the Shapiro-Wilk test, Levene’s test, and independent and paired samples t-tests via SPSS software version 26.
The findings revealed significant weight increases (P< 0.001), Body Mass Index (BMI) (P< 0.001), waist-to-hip ratio (WHR) (P< 0.001), and skeletal muscle mass (SMM) (P< 0.001) following the implementation of the combined exercise program. Additionally, fasting insulin levels (P< 0.001), fasting blood glucose levels (P< 0.001), and HbA1c levels (P< 0.001) significantly decreased in the exercise group in comparison to the control group. However, no significant difference was observed in the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) index (P= 0.758) between the groups. Notably, serum levels of the muscle atrophy markers MuRF-1 (P< 0.001) and Atrogin-1 (P< 0.001) exhibited significant reductions following eight weeks of combined exercise training.
This study represents one of the few investigations to concurrently examine alterations in serum levels of both MuRF-1 and Atrogin-1 following combined exercise training. The results indicate that combined exercise training may effectively reduce muscle atrophy in individuals with type 2 diabetes by lowering serum levels of MuRF-1 and Atrogin-1. Furthermore, engaging in combined physical activity may yield overall health benefits for individuals affected by type 2 diabetes.
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