Daneshvar Medicine

Daneshvar Medicine

The effect of lifetime aerobic exercise on memory and the interleukin-10 in the hippocampus and prefrontal cortex of mice with traumatic brain injury

Document Type : Original Article

Authors
Saeed naghibi 1
vajihe javanbakht 2
mohammad shariatzade 3
alireza fatahian 4
1 Department of Exercise Physiology, Payam Noor University of Karaj, Alborz, Iran.
2 Master's degree in Exercise Physiology, Payam Noor University, Tehran, Iran.
3 Associate Professor, Physical Activity and Health Department, Physical Education and Sport Sciences Research Institute, Tehran, Iran,
4 Department of Sports Physiology, Faculty of Sport Sciences and Health, University of Tehran, Tehran,
10.22070/daneshmed.2025.20550.1612
Abstract
Background and Aim: In recent decades, exercise intervention has emerged as a crucial lifestyle factor for enhancing learning and memory function. Therefore, this study aimed to investigate the effect of lifelong aerobic exercise on spatial memory and hippocampal and prefrontal cortex interleukin-10 in rats with traumatic brain injury.
Materials and Methods: For this purpose, 40 male NMRI laboratory rats, approximately 20 days old and weighing 8-9 grams, were obtained. After an initial acclimatization period, they were randomly divided into four groups of 10: 1. Inactive without brain injury, 2. Exercising without brain injury, 3. Inactive with induced mild brain injury, and 4. Exercising with induced mild brain injury. Following the induction of brain trauma via free-fall impact to the head, behavioral memory tests were conducted using the Morris water maze, and interleukin-10 levels were measured using the ELISA technique. Data were analyzed using one-way ANOVA and Tukey's post-hoc test.
Findings: The analysis of the findings revealed that aerobic exercise had a significant effect on memory, hippocampal interleukin-10, and prefrontal cortex interleukin-10 in rats with traumatic brain injury (P < 0.05).
Conclusion: It appears that aerobic exercise can have a positive and significant impact on the hippocampus and prefrontal cortex, contributing to improved memory in rats with traumatic brain injury.
Subjects
Daneshvar Medicine
Volume 33, Issue 2 - Serial Number 177
July and August 2025
Pages 43-50