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The effect of six weeks of incremental aerobic training on PRDM16 and PPAR-y protein levels in adipose tissue of streptozotocin-induced diabetic rats

Document Type : Original Article

Authors
Aida ghasemi Rahimbegloo 1
ABDOLLAH HASHEMVARZI 2
Abdolreza jafari chashmi 3
1 Sari Branch, Islamic Azad University, Sari, Iran
2 Department of Exercise Physiology, Sari Branch
3 Faculty member ,Department of Exercise Physiology , Sari Branch, Islamic Azad University, Sari, Iran
10.22070/daneshmed.2025.20137.1586
Abstract
Background and Objective: Regular exercise can be a protective and therapeutic strategy against diabetes. The purpose of this study was to investigate the effect of six weeks of incremental aerobic training on the levels of PRDM16 and PPAR-y in adipose tissue of streptozotocin-induced diabetic rats.
Materials and Methods: 32 rats weighing 240-220 g were divided into four groups: control, sham, diabetes, diabetes + exercise. The training group practiced on the treadmill six weeks and five days a week with 60-70% VO2max intensity. To develop the model of diabetes, STZ was injected intraperitoneally at a dose of 60 mg / kg in combination with citrate buffer and pH 4.5. Levels of PPAR-y and PRDM16 white adipose tissue of rats were measured by ELISA kits.
Results: The levels of PPAR-y and PRDM16 were significantly decreased in the diabetes group (P = 0.00). PPAR-y and PRDM16 values were significantly increased in the diabetic + training group (P = 0.0001). Overall, the results showed that PPAR-y and PRDM16 values were significantly increased in the exercise group compared to the diabetes group.
Conclusion:Therefore, it seems that incremental aerobic exercise for six weeks can be a non-invasive treatment for white adipose tissue disorders caused by diabetes.
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Daneshvar Medicine
Volume 33, Issue 1 - Serial Number 176
March and April 2025
Pages 17-22