Changes in serum irisin levels of obese and overweight men after 12 weeks of interval training with different intensities

Document Type : Original Article

Authors

1 Bojnourd Education Department, Bojnourd, Iran

2 Department of Physical Education, University of Tehran, Tehran, Iran

Abstract

Background and Objective: The structural and functional changes of white adipose tissue in the direction of browning can help obese and overweight people to lose weight and the resulting metabolic disorders by increasing energy expenditure.Therefore, in the present study, the effect of 12 weeks of low intensity, medium intensity and high intensity intermittent exercise on serum levels of irisin in healthy, obese and overweight men was investigated.
Materials and Methods: In this study 47 obese and overweight young men(20.50 ± 0.73 years old) participated. The participants were randomly assigned to four groups of light intensity (n=12), moderate(n=12), high(n=12) and control group (n=11). 12 week interval training were run with light (58-63%), moderate (73-78%) and high intensity (88-93%) for 25 to 63 minutes and three sessions per week.To measure the serum indices of irisin, fasting blood samples were taken 48 hours before and after the training program. Statistical data were analyzed using univariate analysis of covariance test and at the significant level (p <0.05).
Results: In this study, 12 weeks of intermittent exercise on different intensites could not cause a significant change in the irisin serum level, Also no significant difference was observed between the training groups(P> 0.05).However, intermittent exercise with both moderate and high intensity led to a significant decrease and increase in body fat percentage and VO2max in overweight and obese men (P<0.05).
Conclusion: 12 weeks of intermittent exercise with different intensities, despite no change in serum irisin level, improved body composition and increased VO2max in obese and overweight young men in two moderate and high intensity groups.
Background and Objective: The structural and functional changes of white adipose tissue in the direction of browning can help obese and overweight people to lose weight and the resulting metabolic disorders by increasing energy expenditure.Therefore, in the present study, the effect of 12 weeks of low intensity, medium intensity and high intensity intermittent exercise on serum levels of irisin in healthy, obese and overweight men was investigated.
Materials and Methods: In this study 47 obese and overweight young men(20.50 ± 0.73 years old) participated. The participants were randomly assigned to four groups of light intensity (n=12), moderate(n=12), high(n=12) and control group (n=11). 12 week interval training were run with light (58-63%), moderate (73-78%) and high intensity (88-93%) for 25 to 63 minutes and three sessions per week.To measure the serum indices of irisin, fasting blood samples were taken 48 hours before and after the training program. Statistical data were analyzed using univariate analysis of covariance test and at the significant level (p <0.05).
Results: In this study, 12 weeks of intermittent exercise on different intensites could not cause a significant change in the irisin serum level, Also no significant difference was observed between the training groups(P> 0.05).However, intermittent exercise with both moderate and high intensity led to a significant decrease and increase in body fat percentage and VO2max in overweight and obese men (P<0.05).
Conclusion: 12 weeks of intermittent exercise with different intensities, despite no change in serum irisin level, improved body composition and increased VO2max in obese and overweight young men in two moderate and high intensity groups.

Keywords

Main Subjects

References

  1. Goossens GH. The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function. Obesity Facts 2017;10(3):207-15. DOI: 10.1159/000471488.
  2. Vidal P, Stanford KI. Exercise-Induced Adaptations to Adipose Tissue Thermogenesis. Frontiers in Endocrinology (Lausanne) 2020;11:270. DOI: 10.3389/fendo.2020.00270.
  3. Enerback S. Brown adipose tissue in humans. International Journal of Obesity(Lond) 2010;34 (Suppl 1):S43-6. DOI: 10.1038/ijo.2010.183.
  4. Bartelt A, Heeren J. Adipose tissue browning and metabolic health. Nature Reviews Endocrinology 2014;10(1):24-36. DOI: 10.1038/nrendo.2013.204.
  5. Chen Y, Ding J, Zhao Y, Ju S, Mao H, Peng XG. Irisin induces white adipose tissue browning in mice as assessed by magnetic resonance imaging. Experimental Biology and Medicine (Maywood) 2021;246(14):1597-606. DOI: 10.1177/15353702211006049
  6. Rabiee F, Lachinani L, Ghaedi S, Nasr-Esfahani MH, Megraw TL, Ghaedi K. New insights into the cellular activities of Fndc5/Irisin and its signaling pathways. Cell BioSciences 2020;10:51. doi: 10.1186/s13578-020-00413-3. PMID: 32257109; PMCID: PMC7106581.
  7. Arhire LI, Mihalache L, Covasa M. Irisin: A Hope in Understanding and Managing Obesity and Metabolic Syndrome. Frontiers in Endocrinology (Lausanne) 2019;10:524. DOI: 10.3389/fendo.2019.00524.
  8. Bostrom P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, et al. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis.Nature 2012;481(7382):463-8. DOI: 10.1038/ nature10777.
  9. Bernal-Rivas C, Llamunao-Tropa A, Reyes-Barría A, Halabi D, Pavicic F, Ehrenfeld P, Martínez-HuenchullánS. Effects of exercise on irisin in subjects with overweight or obesity. A systematic reviewof clinical studies. Nutricion Hospitalaria 2022;39(6):1389-1396. DOI: http://dx.doi.org/10.20960/nh.04202.
  10. Lagzdina R, Rumaka M, Gersone G, Tretjakovs P. Circulating Irisin in Healthy Adults: Changes after Acute Exercise, Correlation with Body Composition, and Energy Expenditure Parameters in Cross-Sectional Study. Medicina (Kaunas) 2020;56(6). DOI: 10.3390/medicina56060274.
  11. Shirzad J, Tofighi A, Tolouei-Azar J, Khadem-Ansari H. Adaptation of Irisin, Follistatin and Myostatin to 8 weeks of Resistance, Endurance and Concurrent Training in Obese Men. Sport Physiology&Manage ment Investigations. 2021;12(4):23-41. Available from: https://www.sid.ir/en/journal/View Paper.aspx?id=811927. [Article in Persian]
  12. Benedini S, Dozio E, Invernizzi PL, Vianello E, Banfi G, Terruzzi I, Luzi L, Romanelli MMC. Irisin: A Potential Link between Physical Exercise and Metabolism - an Observational Study in Differently Trained Subjects, from Elite Athletes to Sedentary People. Journal of Diabetes Research 2017;7.
  13. Batitucci G, Brandao CFC, De Carvalho FG, Marchini JS, Pfrimer K, Ferrioli E, et al. Taurine supplementation increases irisin levels after high intensity physical training in obese women. Cytokine 2019;123:154741. DOI: 10.1016/j. cyto.2019.154741.
  14. Dianatinasab A, Koroni R, Bahramian M, Bagheri-Hosseinabadi Z, Vaismoradi M, Fararouei M, et al. The effects of aerobic, resistance, and combined exercises on the plasma irisin levels, HOMA-IR, and lipid profiles in women with metabolic syndrome: A randomized controlled trial. Journal of Exercise Science and Fitness 2020;18(3):168-76. DOI: 10.1016/j.jesf.2020.06.004.
  15. Wewege M, vanden Berg R, Ward RE, Keech A. The effects of high-intensity interval training vs. moderate-intensity continuous training on body composition in overweight and obese adults: a systematic review and meta-analysis . Obesity Reviews 2017;18(6): 635-646.
  16. Jackson AS, Pollock ML. Generalized equations for predicting body density of men. British Journal of Nutrition. 1978; 40(3): 497-504.
  17. Kline GM, Porcari JP, Hintermeister R, Freedson PS, Ward A, McCarron RF, et al. Estimation of VO2max from a one-mile track walk, gender, age, and body weight. Medicine & Science in Sports & Exercise 1987 Jun;19(3):253-9.
  18. ThompsonWR, Gordon NF, Pescatello LS.ACSM's guidelines for exercise testing and prescription.American College of Sports Medicine8th ed 2010.
  19. MargariaR,CerretelliP,AghemoP,SassiG.Energy cost of Journal of Applied Physiology 1963;18:367-370.
  20. Uth N, Sorensen H, Overgaard K, Pedersen PK. Estimation of VO2max from the Ratio between HRmax and HRrest-the Heart Rate Ratio Method.European Journal of Applied Physiology 2004;91(1):111-5.
  21. Tanaka H, Monhan K.D, Seals DG. Age-predicted maximal heart rate revisited. American College of Cardiology 2001; 37:153-156.
  22. Pugh LG.The influence of wind resistance in running and walking and the mechanical efficiency of work against horizontal or vertical forces.Journal of Physiology 1971;213(2):255-276.
  23. Winn NC, Liu Y, Heden TD, Nyhoff LM, Boyle LJ, Kanaley FACSM JA. Circulating Irisin Levels In Response To Acute And Chronic Exercise In Obese Adults. International Journal of Exercise Science: Conference Proceeding 2014; 11(1):42.
  24. Kurdiova T, Balaz M, Ukropcova B. Effects of obesity, diabetes and exercise on FNDC5 gene expression and irisin release in humanskeletal muscle and adipose tissue: in vivo and in vitro studies. Journal of Physiology 2014; 592:1091–
  25. Hecksteden A, Wegmann M, Steffen A,Kraushaar J, Morsch A, Ruppenthal S, Kaestner L, Meyer T. Irisin and exercise training in humansresultsfrom a randmized controlled training trial. BioMed Central Medicine 2013;11(1):1. https://doi.org/10.1186/1741-7015-11-235.
  26. Shabani R, Izaddoust F. Effects of aerobic training, resistance training, or both on circulating irisin and myostatin in untrained women. ActaGymnica.2018; 2(48): 47–
  27. Hakimi M, Attarzadeh Hosseini SR. Changes in serum iris levels and lipid profiles of overweight male students after eight weeks of aerobic exercise. Scientific Research Journal of Shahid Sadoughi University of Medical Sciences, Yazd 2015; 23(12):1189-1201.
  28. Alizadeh L, Tawfiqi A, Tolouei Azar J. The effect of eight weeks of high-intensity intermittent exercise on serum levels of irisin, FGF21 and glycemic index in type 2 diabetic women. Journal of Applied Health Studies in Exercise Physiology 2018; 6(2): 17-24.
  29. Tawfiqi A, Alizadeh R, Tolouei Azar J. The effect of eight weeks of high-intensity interval training on serum levels of irisin and FGF21 in obese and inactive women. Journal of Urmia University of Medical Sciences 2017; 28(7):453-466.
  30. Raschke S, Elsen M, Gassenhuber H, Sommerfeld M, Schwahn U, Brockmann B, Jung R, Wisløff U, Tjønna AE, Raastad T, Hallén J, Norheim F, Drevon CA, Romacho T, Eckardt K, Eckel J. Evidence against a beneficial effect of irisin in humans. PLoS One 2013;8(9):e73680. doi: 10.1371/journal.pone.0073680. PMID: 24040023; PMCID: PMC3770677.
  31. Timmons JA, Baar K, Davidsen PK, Atherton PJ. Is irisin a human exercise gene? Nature 2012 Aug 30;488(7413):E9-10; discussion E10-1. doi: 10.1038/nature11364. PMID: 22932392.
  32. Wu J, Boström P, Sparks LM, Ye L, Choi JH, Giang AH, et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 2012;150(2):366-76. doi: 10.1016/j.cell.2012.05.016. Epub 2012 Jul 12. PMID: 22796012; PMCID: PMC3402601.
  33. Schumacher MA, Chinnam N, Ohashi T, Shah RS, Erickson HP. The structure of irisin reveals a novel intersubunit β-sheet fibronectin type III (FNIII) dimer: implications for receptor activation. Journal of Biological Chemistry 2013;288(47):33738-33744. doi: 10.1074/jbc.M113.516641. Epub 2013 Oct 10. PMID: 24114836; PMCID: PMC3837118.
  34. Bluher S, Panagiotou G, Petroff D, Markert J, Wagner A, Klemm T, et al. Effects of a 1-year exercise and lifestyle intervention on irisin, adipokines, and inflammatory markers in obese children. Obesity (Silver Spring) 2014; 22(7):1701-1708.
  35. Knuth CM, Peppler WT, Townsend LK, Miotto PM, Gudiksen A, Wright DC. Prior exercise training improves cold tolerance independent of indices associated with non-shivering thermogenesis. Journal of Physiology 2018; 596:4375–
  36. Tsiloulis T, Carey AL, Bayliss J, Canny B, Meex RCR, Watt MJ. No evidence of white adipocyte browning after endurance exercise training in obese men. International Journal of Obesity(Lond) 2018; 42:721–
  37. Korkmaz A, Venojarvi M, Wasenius N, Manderoos S, Deruisseau KC, Gidlund EK, et al. Plasma irisin is increased following 12 weeks of Nordic walking and associates with glucose homoeostasis in overweight/obese men with impaired glucose regulation. European Journal of Sport Science 2019;19(2):258-66. DOI: 10.1080/17461391.2018.1506504.
Daneshvar Medicine
Volume 32, Issue 3 - Serial Number 172
September and October 2024
Pages 68-79

Files

Share

How to cite

Statistics